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TRANSDERM-NITRO® Novartis Pharmaceuticals Nitroglycerin Transdermal Antianginal Action and Clinical The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle, producing a vasodilator effect on both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the postcapillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure (preload). Arteriolar relaxation reduces system vascular…

TOPSYN® Medicis Fluocinonide Topical Corticosteroid Indications And Clinical Uses: For topical therapy of corticosteroid-responsive acute and chronic skin eruptions, where an anti-inflammatory, anti-allergenic and antipruritic activity in the topical management is required. Contra-Indications: Untreated bacterial, tubercular, fungal and most viral lesions of skin (including herpes simplex, vaccinia and varicella). Hypersensitivity to any of the components.WarningWarnings: Warnings in Clinical States: Pregnancy and Lactation: The safety of topical corticosteroids during pregnancy or…

TRANDATE® Roberts Labetalol HCl Antihypertensive Action and Clinical Labetalol is an adrenergic receptor blocking agent possessing both alpha 1-(post-synaptic) and beta-receptor blocking activity. Its action on beta-receptors is 4 times stronger than that on alpha-receptors. It antagonizes beta 1- and beta 2-receptors equally. The mechanism of the antihypertensive action of labetalol has not been fully established. It is considered that labetalol lowers blood pressure by partially blocking the alpha-adrenoceptors in…

TRANS-PLANTAR® TRANS-VER-SAL® Westwood-Squibb Salicylic Acid Plantar Wart Therapy Verrucae Therapy Indications and Clinical Uses: Indications Trans-Plantar: For the treatment of plantar warts. Trans-Ver-•Sal: For the treatment of common wart infections. Contraindications: Should not be used by patients with diabetes or impaired blood circulation unless directed by physician. Do not use on moles, birthmarks, uro-genital warts and warts with hair. It is contraindicated for patients with a known sensitivity to any…

TONOCARD® AstraZeneca Tocainide HCl Antiarrhythmic Agent Action and Clinical Tocainide is a primary amine analog of lidocaine. Its electrophysiologic properties are similar to those of lidocaine. It possesses class IB properties in the modified electrophysiological classification of antiarrhythmic drugs proposed by Vaughan-Williams. In studies of isolated dog Purkinje fibres, tocainide in concentrations of 1 to 50 g/mL had no significant effect on resting membrane potential, but reduced the amplitude and…

TOPICORT® Preparations Hoechst Marion Roussel Desoximetasone Topical Corticosteroid Action and Clinical Topicort preparations are primarily effective because of their anti-inflammatory, antipruritic and vasoconstrictive actions. Indications And Clinical Uses: For the relief of acute or chronic corticosteroid-responsive dermatoses. Contra-Indications: Topical corticosteroids are contraindicated in untreated bacterial, tubercular, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella) and in those patients with a history of hypersensitivity to…

TOLECTIN® Janssen-Ortho Tolmetin Sodium Anti-inflammatory–Analgesic–Antipyretic Action and Clinical Tolmetin has demonstrated anti-inflammatory, analgesic and antipyretic properties in classical animal test systems. In patients with rheumatoid arthritis, the anti-inflammatory action has been shown by a reduction in joint swelling, pain and duration of morning stiffness, as well as by enhanced grip strength, increased mobility and increased delay in the onset of fatigue. Studies in laboratory animals and man have demonstrated that…

TOLEREX® Novartis Nutrition Elemental Diet Indications And Clinical Uses: A nutritionally complete elemental diet formulated for the nutritional management of patients with impaired digestion and absorption. May include those with inflammatory bowel disease, intestinal atresia, pancreatitis, fistula, partial obstruction, short-gut syndrome. Malnutrition and cachexia. Bowel preparation prior to diagnostic and surgical procedures. Transition diet between parenteral and normal oral feeding. Food sensitivities.: Precautions: Not for parenteral administration. For use only…

TOMYCINE™ CIBA Vision Tobramycin Topical Antibiotic Availability And Storage: Each mL of sterile ophthalmic solution contains: tobramycin 0.3% (3 mg/mL). Nonmedicinal ingredients: benzalkonium chloride (preservative), boric acid, purified water, sodium chloride, sodium hydroxide and/or sulfuric acid (to adjust pH), sodium sulfate and tyloxapol. Plastic squeeze bottles of 5 mL. Avoid contamination of the dropper tip by avoiding contact with the eye, skin or other surfaces. Keep this bottle tightly closed…

TOBREX® Alcon Tobramycin Topical Antibiotic Action and Clinical Like other aminoglycosides, the bactericidal activity of tobramycin is accomplished by specific inhibition of normal protein synthesis in susceptible bacteria, but at the present time, very little is known about this action. It is thought that inhibition of synthesis is due to an action on ribosomes that, in turn, causes bacterial misreading of messenger RNA. Because the ocular concentrations of tobramycin achieved…