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TICLID® Roche Ticlopidine HCl Inhibitor of Platelet Function Action and Clinical Uses: Ticlopidine is an inhibitor of platelet aggregation. It causes a time and dose-dependent inhibition of platelet aggregation and release of platelet factors, as well as a prolongation of bleeding time. The drug has no significant in vitro activity. The exact mechanism of action is not fully characterized, but does not involve inhibition of the prostacyclin/thromboxane pathways or platelet…

TILADE® Rh´ne-Poulenc Rorer Nedocromil Sodium Bronchial Anti-inflammatory Agent Action and Clinical Uses: Nedocromil sodium is a new chemical entity that inhibits the release of inflammatory mediators from a variety of cell types occurring in the lumen and in the mucosa of the bronchial tree. When it is administered topically to the bronchi, it displays specific anti-inflammatory properties. Laboratory experiments have shown that nedocromil sodium prevents the release of inflammatory chemotactic…

THROMBOSTAT™ Parke-Davis Thrombin (Bovine Origin) Topical Hemostatic Action and Clinical Uses: Thrombostat is a protein substance produced through a conversion reaction in which prothrombin of bovine origin is activated by tissue thromboplastin in the presence of calcium chloride. Thrombin requires no intermediate physiological agent for its action. It clots the fibrinogen of the blood directly. Failure to clot blood occurs in the rare case where the primary clotting defect is…

THYROID HORMONE Parke-Davis Desiccated Thyroid Hypothyroidism Therapy Action and Clinical Uses: The principal pharmacologic effect of exogenous thyroid hormones is to increase the metabolic rate of body tissues. The normal thyroid gland contains approximately 200 g of levothyroxine (T 4)/g of gland, and 15 g of triiodothyronine (T 3)/g. The ratio of these two hormones in the circulation does not represent the ratio in the thyroid gland, since about 80%…

THIOTEPA Wyeth-Ayerst Cytotoxic Agent Action and Clinical Uses: Thiotepa is a cytotoxic agent of the polyfunctional alkylating type (more than one reactive ethylenimine group) related chemically and pharmacologically to nitrogen mustard. Its radiomimetic action is believed to occur through the release of ethylenimine radicals which, like irradiation, disrupt the bonds of DNA. One of the principal bond disruptions is initiated by alkylation of guanine at the N-7 position, which severs…

THROMBATE III® Bayer Antithrombin III (Human) Anticoagulant Action and Clinical Uses: Antithrombin III (AT-III), an alpha 2-glycoprotein of molecular weight 58 000, is normally present in human plasma at a concentration of approximately 12.5 mg/dL and is the major plasma inhibitor of thrombin. Inactivation of thrombin by AT-III occurs by formation of a covalent bond resulting in an inactive 1:1 stoichiometric complex between the two, involving an interaction of the active serine…

THEOCHRON® SR Riva Theophylline Bronchodilator Action and Clinical Theophylline is a bronchodilator which directly relaxes the smooth muscle of the bronchial airways and pulmonary and coronary blood vessels. These actions may be mediated through inhibition of phosphodiesterase and a resultant increase in intracellular cyclic AMP. Theophylline sustained release tablets produce peak blood levels of theophylline between 5 and 8 hours following dosing in adults. Once a steady state level has…

THEOPHYLLINE Solution Desbergers Bronchodilator–Expectorant Availability And Storage: Each 15 mL of red-orange, raspberry-flavored syrup contains: theophylline 80 mg. Nonmedicinal ingredients: FD&C red No. 2, FD&C yellow No. 6, glycerin, potassium sorbate, propylene glycol, purified water, raspberry flavoring, sodium benzoate and sorbitol. Energy: 37.1 kJ (8.7 kcal)/5 mL. Alcohol-, bisulfite-, gluten-, lactose-, parabens-, sucrose- and tartrazine-free. Bottles of 500 mL. THEOPHYLLINE Solution Desbergers Bronchodilator–Expectorant

THALARIS Technilab Hypertonic Sea Salt Solution Decongestant–Antibacterial Availability And Storage: Each mL of gargle and oral rinse contains: sodium chloride 2.98% w/v (as hypertonic sea salt solution) with benzalkonium chloride as preservative. Bottles of 500 m THALARIS Technilab Hypertonic Sea Salt Solution Decongestant–Antibacterial

THEO-DUR® AstraZeneca Theophylline Bronchodilator Action and Clinical Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels to relieve bronchospasm and increase flow rates and vital capacity. It also produces other actions typical of the xanthine derivatives: coronary vasodilation, diuresis, increase in gastric secretion, and cardiac, cerebral, and skeletal muscle stimulation. The actions of theophylline may be mediated through inhibition of phosphodiesterase and a resultant increase in…