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ERGAMISOL® Janssen-Ortho Levamisole HCl Immunomodulator Action And Clinical Pharmacology: Levamisole is capable of restoring impaired immune responses preferentially of the cell mediated type in compromised hosts. Therapeutic doses of levamisole restore to normal the functions of monocytes (phagocytes) and T lymphocytes but do not directly influence B cells. Levamisole is rapidly absorbed from the gastrointestinal tract following a single oral ingestion of 150 mg. In patients with neoplastic disease, a…

ENTROPHEN® Johnson & Johnson• Merck ASA Nonsteroidal Anti-inflammatory – Analgesic – Platelet Aggregation Inhibitor Action And Clinical Pharmacology: ASA has analgesic, antipyretic and anti-inflammatory properties. In rheumatic diseases, although the analgesic and antipyretic effects are useful, the major purpose for which ASA is used is to reduce the intensity of the inflammatory process. Inhibition of prostaglandin synthesis may be involved in the anti-inflammatory action of ASA. ASA also alters platelet…

EPHEDRINE HCl Roberts Decongestant Action And Clinical Pharmacology: Ephedrine is an adrenergic drug which exerts peripheral effects resembling those of epinephrine and central effects resembling those of the amphetamines. Ephedrine produces a more sustained action but is less potent than epinephrine. It stimulates both alpha and beta receptors and its peripheral actions are due partly to norepinephrine release and partly to direct effects on receptors. Ephedrine stimulates the heart, elevating…

EPIPEN® EPIPEN® JR. Allerex Epinephrine Allergy Therapy Auto-Injector Action And Clinical Pharmacology: Epinephrine is a sympathomimetic drug, acting on both alpha and beta receptors. It is the drug of choice for the emergency treatment of severe allergic reactions to insect bites, insect stings, food, medication and other allergens. It is also indicated for the temporary emergency treatment of severe, life-threatening asthma attacks. The strong vasoconstrictor action of epinephrine acts quickly…

ENTACYL® Roberts Piperazine Adipate Anthelmintic Indications And Clinical Uses: Pinworm or roundworm infestations. Contra-Indications: Impaired renal or hepatic function, convulsive disorders, or a history of hypersensitivity reactions to piperazine or its salts. Precautions: In children, avoid prolonged or repeated treatment in excess of that recommended due to potential neurotoxicity. Pregnancy: Safety of this drug for use during pregnancy has not been established. If CNS, significant gastrointestinal, or hypersensitivity reactions occur,…

ENTOCORT® Capsules Astra Budesonide Glucocorticosteroid for the Treatment of Crohn’s Disease Affecting the Ileum and/or Ascending Colon Action And Clinical Pharmacology: The active ingredient of Entocort capsules, budesonide, is a potent nonhalogenated synthetic glucocorticosteroid with high topical potency and weak systemic effects. The exact mechanism of action of glucocorticosteroids in the treatment of Crohn’s disease is not fully understood. Anti-inflammatory actions, such as the inhibition of inflammatory mediator release and…

ENTOCORT® Enema Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency. It undergoes an extensive degree (approximately 90%) of biotransformation in the liver to metabolites with low glucocorticosteroid activity. The glucocorticosteroid activity of the major metabolites, 6b-hydroxybudesonide and 16a-hydroxyprednisolone, is less than 1% of that of budesonide. The favorable separation between…

ENFALAC PREGESTIMIL® Mead Johnson Protein Hydrolysate Formula Pediatric Elemental Diet Indications And Clinical Uses: For feeding of infants and children with malabsorption problems which may include: disaccharidase deficiency (relative or absolute), idiopathic defects in digestion or absorption, steatorrhea, cystic fibrosis, food allergies and intestinal resection. Precautions: Patients with lengthy episodes of diarrhea and/or receiving antibiotics may require supplemental vitamin K. In a few instances, premature infants and infants with long-standing…

ENFALAC PROSOBEE® Mead Johnson Soy Protein Isolate Hypoallergenic Product Indications And Clinical Uses: Formula for feeding infants or children with a sensitivity to cow milk protein or a family history of allergies. Symptoms that may require a milk-free source of nutrition include the following: persistent and unexplained eczema, diarrhea, non-specific respiratory disorders, spitting up, and irritability. May be used for adults with food allergies. Precautions: Opened or prepared formula should…

ENLON® Zeneca Edrophonium Chloride Nondepolarizing Neuromuscular Antagonist Action And Clinical Pharmacology: Edrophonium chloride is an anticholinesterase agent which antagonizes the action of nondepolarizing neuromuscular blocking drugs. Edrophonium chloride inactivates the enzyme acetylcholinesterase by combining with it in a reversible manner. The inactivation of the enzyme prevents the hydrolysis of acetylcholine and allows the accumulation of the neurotransmitter. The accumulation of acetylcholine at cholinergic receptor sites leads to the resumption of…