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FEMARA® Novartis Pharmaceuticals Letrozole Nonsteroidal Aromatase Inhibitor – Inhibitor of Estrogen Biosynthesis – Antitumor Agent Action And Clinical Pharmacology: Letrozole is a potent and highly specific nonsteroidal aromatase inhibitor. It inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. Letrozole exerts its antitumor effect by depriving estrogen-dependent breast cancer cells of…

FER-IN-SOL® Mead Johnson Ferrous Sulfate Hematinic Indications And Clinical Uses: Prevention and treatment of iron deficiency anemia. Contra-Indications: Hemosiderosis, hemochromatosis, hemolytic anemia. Precautions: Oral iron preparations may aggravate existing peptic ulcer, regional enteritis and ulcerative colitis. Iron compounds taken orally can impair the absorption of tetracycline antibiotics. Antacids given concomitantly with iron compounds decrease iron absorption. When iron drops are given to babies some darkening of the gum tissue directly…

FERMALAC® Rougier Lactobacillus Acidophilus Compound Flora Modifier Indications And Clinical Uses: The treatment of mild diarrhea and intestinal upset, particularly when associated with antibiotic therapy. Precautions: Store under refrigeration. Should not be used to prepare yogurt or acidophilus milk. Dosage: Adults: 1 to 2 capsules 3 times/day. Availability And Storage: Each No. 0 enteric coated capsule with opaque blue top and opaque white bottom contains: 1 billion fully viable bacilli…

FASTIN® SmithKline Beecham Phentermine HCl Anorexiant Action And Clinical Pharmacology: Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include CNS stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity are commonly known…

FAMVIR™ SmithKline Beecham Famciclovir Antiviral Agent Action And Clinical Pharmacology: Famciclovir is the orally administered pro-drug of the antiviral agent penciclovir. Famciclovir itself has no antiviral activity until it is biotransformed to penciclovir. Following oral administration little or no famciclovir is detected in plasma or urine since famciclovir is rapidly converted via deacetylation and oxidation to penciclovir. Studies in volunteers have shown that famciclovir is well absorbed and produces plasma…

EUMOVATE® Glaxo Wellcome Clobetasone 17-butyrate Topical Corticosteroid Action And Clinical Pharmacology: The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasone are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, anti-puritic, and vasoconstrictive actions. However while the physiologic, pharmacologic…

EUGLUCON® Pharmascience Glyburide Oral Hypoglycemic Indications And Clinical Uses: To control hyperglycemia in glyburide responsive diabetes mellitus of stable, mild, nonketosis prone, maturity-onset or adult type which cannot be controlled by proper dietary management and exercise, or when insulin therapy is not appropriate. Contra-Indications: Known hypersensitivity or allergy to glyburide; unstable and/or insulin-dependent diabetes mellitus; ketoacidosis; coma; stress conditions such as severe infections, trauma or surgery; the presence of jaundice,…

ETRAFON® Preparations Schering Amitriptyline HCl – Perphenazine Antidepressant – Antipsychotic Indications And Clinical Uses: The treatment of patients with anxious or agitated depression. Particularly indicated in patients with depression associated with marked psychomotor unrest and anxiety. Etrafon has also been used in some schizophrenic patients who have associated symptoms of depression and in depressed patients suffering from marked agitation, anxiety and tension, which may respond to a phenothiazine agent. Contraindications,…

ETHAMBUTOL HCl General Monograph Antimycobacterial Pharmacology: Ethambutol is a bacteriostatic agent which diffuses into actively growing mycobacterium cells such as tubercle bacilli, where it inhibits the synthesis of one or more essential metabolites, causing impairment of cell metabolism, arrest of multiplication, and cell death. It is active in vitro against strains of M. tuberculosis and other Mycobacterium species, but not other bacteria, fungi or viruses. Resistance develops rapidly if ethambutol…

ETHRANE® Zeneca Enflurane  Inhalation Anesthetic Action And Clinical Pharmacology: Enflurane is an inhalation anesthetic. Induction and recovery from anesthesia with enflurane are rapid. Enflurane does not appear to stimulate excessive salivation or tracheabronchial secretions, or affect bronchomotor tone. Pharyngeal and laryngeal reflexes are readily obtunded. The level of anesthesia changes rapidly, which would be predicted based upon its Oswald partition coefficients. Enflurane reduces ventilation as depth of anesthesia increases. This…