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NUTROPIN® NUTROPIN® AQ Roche Somatropin Growth Hormone Action And Clinical Pharmacology: General: Somatropin is a human growth hormone (hGH) produced by recombinant DNA technology. The amino acid sequence of the somatropin protein is identical to that of pituitary-derived human growth hormone. In vitro and in vivo preclinical testing, and clinical testing have demonstrated that somatropin is therapeutically equivalent to pituitary-derived human growth hormone in pharmacokinetics, in stimulation of linear growth…

NUMORPHAN® DuPont Pharma Oxymorphone HCl Analgesic Action And Clinical Pharmacology: Oxymorphone is a potent narcotic analgesic. When administered parenterally, 1 mg is approximately equivalent in analgesic activity to 10 mg of morphine sulfate. The onset of action of parenterally injected oxymorphone is rapid and the initial effects are usually perceived within 5 to 10 minutes, with analgesia persisting for approximately 3 to 6 hours. Oxymorphone is conjugated with glucuronic acid…

NUPERCAINAL® Cream NUPERCAINAL® Ointment Novartis Consumer Health Dibucaine – Domiphen Bromide Topical Anesthetic Indications And Clinical Uses: For the relief of pain and itching in hemorrhoids, anal fissure, abrasions, minor burns, sunburn, chapping, herpes simplex, herpes zoster, insect bites, pruritus. The cream is also indicated for local antisepsis. Precautions: Not more than 2 tubes of the cream, or 1 tube of the ointment, should be applied within 24 hours to…

NUROMAX™ Glaxo Wellcome Doxacurium Chloride Nondepolarizing Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Doxacurium is a long-acting, nondepolarizing, skeletal neuromuscular blocking agent for i.v. administration. Nondepolarizing agents antagonize the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plates. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine. Pharmacodynamics: Doxacurium is approximately 2.5 to 3 times more potent than…

NOVOLIN®GE Preparations Novo Nordisk Insulin Human (Biosynthetic) Antidiabetic Agent Action And Clinical Pharmacology: Novolin®ge Biosynthetic Human Insulin is a polypeptide structurally identical to natural human insulin. Novolin®ge is produced by recombinant DNA technology, using Saccharomyces cerevisiae (baker’s yeast). The content of immunoreactive peptides derived from the used microorganism (yeast) is undetectable (less than 1 ppm by weight of the dry insulin) as determined by enzyme linked immunoabsorbent assay. When administered…

NOVASOURCE™ RENAL Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A nutritionally complete, calorically dense, moderate protein formula with a vitamin/mineral profile designed for dialysis patients with acute and chronic renal failure. Appropriate for both oral and tube feeding use. Precautions: Not for parenteral administration. Dosage And Administration: 1 000 mL or 8 360 kJ (4.2 Tetra Brik Paks or 2 000 kcal) provides at least 100% of the Canadian…

NOVA-T Berlex Canada Intrauterine Copper Intrauterine Contraceptive Description: Nova-T is an intrauterine device made of plastic (polyethylene) approximately in the shape of a T. Polyethylene threads are attached to the lower portion. The horizontal and vertical arms of the T are 32 mm in length and 1.2 mm in diameter; a loop 2.6 mm wide is found at the tip of the vertical arm; and a thin copper wire (107-141…

NORMACOL® Rivex Pharma Sterculia Bulk Laxative Indications And Clinical Uses: Sterculia is used as a bulk laxative, since by taking up moisture it increases the volume of the feces and promotes peristalsis. Ten mL of sterculia provide dietary bulk equivalent to 2 kg of fresh vegetables. It provides gentle relief of occasional constipation. Produces bowel movement in 12 to 72 hours. Precautions: As with all hygroscopic laxatives, it is important…

NOROXIN® Ophthalmic Solution MSD Norfloxacin Antibacterial Action And Clinical Pharmacology: Norfloxacin ophthalmic solution is a fluoroquinolone carboxylic acid antibacterial agent for ocular administration. Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level 3 specific actions have been attributed to norfloxacin in the inhibition of E. coli cells: inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, inhibition of the relaxation of supercoiled DNA and…

NORLUTATE® Parke-Davis Norethindrone Acetate Progestational Agent Action And Clinical Pharmacology: Norethindrone acetate differs from norethindrone only in potency; the acetate is approximately twice as potent. Transforms proliferative endometrium into secretory endometrium. Inhibits (at the usual dose range) the secretion of pituitary gonadotropins, which in turn prevents follicular maturation and ovulation. May also demonstrate some estrogenic, anabolic or androgenic activity but should not be relied upon. Indications And Clinical Uses: Amenorrhea;…