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OPTICROM® Allergan Sodium Cromoglycate Antiallergic Action And Clinical Pharmacology: In the immediate reaction (Type I), the union of antigen with reaginic antibody leads to the formation and release of mediators of the local anaphylactic reaction. The principal effect of sodium cromoglycate is its specific ability to stabilize the membrane of the mast cell and thus prevent the release of mediators of anaphylaxis. The action appears to be specific for reaginic…

OMNIPAQUE® Nycomed Imaging A.S. Iohexol Nonionic Radiographic Contrast Medium Action And Clinical Pharmacology: Immediately following rapid intravascular injection, iohexol reaches peak plasma concentration and is then rapidly distributed throughout the extracellular fluid compartment. Iohexol does not normally cross the blood-brain barrier to any significant extent. It is excreted unchanged by the kidneys, mainly by glomerular filtration; tubular secretion plays a minor role, and a very small quantity (1 to 2%)…

  ONCOTICE™ Organon Teknika Bacillus Calmette-Guerin (BCG), strain TICE Antineoplastic Action And Clinical Pharmacology: The precise mechanism of OncoTICE’s, [Bacillus Calmette-Guerin (BCG), strain TICE], antitumor action is unknown; however, it appears to exert a variety of actions. OncoTICE induces a granulomatous reaction at the local site of administration. Activated histiocytes responding to the BCG are able to kill tumor cells. BCG acts as both a specific and a nonspecific immunopotentiating…

OCUCLEAR® Schering Oxymetazoline HCl Topical Decongestant Action And Clinical Pharmacology: Oxymetazoline elicits relief of conjunctival hyperemia by causing vasoconstriction of superficial conjunctival blood vessels. The drug’s action has been demonstrated in acute allergic conjunctivitis and in chemical (chloride) conjunctivitis. Oxymetazoline has a lesser tendency to dilate the pupils than 0.12% phenylephrine. There are no clinical data available on the degree and rate of systemic absorption of oxymetazoline when used topically…

OCUFLOX™ Allergan Ofloxacin Antibacterial Agent Action And Clinical Pharmacology: The primary mechanism of action of ofloxacin appears to be the specific inhibition of DNA gyrase (topoisomerase II). This enzyme is responsible for the negative supercoiling of bacterial DNA and consequently for its topological configuration, governing functions such as RNA transcription, protein synthesis, DNA replication and repair functions. Indications And Clinical Uses: For the treatment of conjunctivitis when caused by susceptible…

OCCLUSAL™ Medicis Salicylic Acid Verrucae Therapy Action And Clinical Pharmacology: Although the exact mode of action of salicylic acid in the treatment of warts is not known, its activity appears to be associated with its keratolytic action which results in mechanical removal of epidermal cells infected with wart viruses. Indications And Clinical Uses: In the treatment and removal of common warts and plantar warts. Contra-Indications: Occlusal should not be used…

OCCLUSAL™-HP Medicis Salicylic Acid Verrucae Therapy Action And Clinical Pharmacology: Although the exact mode of action of salicylic acid in the treatment of warts is not known, it activity appears to be associated with its keratolytic action which results in mechanical removal of epidermal cells infected with wart viruses. Indications And Clinical Uses: In the treatment and removal of common warts and plantar warts. Contra-Indications: Occlusal-HP should not be used…

NURSOY® Wyeth-Ayerst Soy Protein Isolate Hypoallergenic Infant Formula Indications And Clinical Uses: A nutritionally complete soy-based and milk- and lactose-free formula for common infant feeding problems associated with lactose intolerance or cow’s-milk protein sensitivity or allergy. Symptoms that may require a milk-free formula include diarrhea, vomiting, spitting up, feeding difficulties, gas, bloating, colic, and fussiness. Iron-fortified Nursoy contains vitamin A in the form of beta-carotene and has a fat blend…

NUTRISOURCE® HN Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, complete fibre containing tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function. Recommended for both short-term and long-term tube feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 6 cans [1 500 mL or 7 520 kJ (1 800 kcal)] provides at least 100%…

NUTRISOURCE® Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A standard, fibre containing tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function. Recommended for both short-term and long-term tube feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 6 cans [1 500 mL or 7 520 kJ (1 800 kcal)] provides at least 100% of the Canadian…