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PUREGON™ Organon Follitropin Beta Gonadotropin Action And Clinical Pharmacology: Puregon is a freeze-dried preparation containing highly purified human follicle stimulating hormone (hFSH) prepared by recombinant DNA technology. The active substance, follitropin beta, is a heterodimeric glycoprotein with a molecular mass of approximately 35-45kD. It is produced by a Chinese hamster ovary (CHO) cell line transfected with a plasmid containing two subunit genes encoding human FSH. Structural analysis has shown that…

PROZAC® Lilly Fluoxetine HCl Antidepressant – Antiobsessional – Antibulimic Action And Clinical Pharmacology: The antidepressant, antiobsessional, and antibulimic actions of fluoxetine are presumed to be linked to its ability to selectively inhibit the neuronal reuptake of serotonin. At clinically relevant doses fluoxetine blocks the uptake of serotonin into human platelets. Antagonism of muscarinic, histaminergic and a1-adrenergic receptors has been hypothesized to be associated with various anticholinergic, sedative and cardiovascular effects…

PROTAMINE SULFATE INJECTION Pharmaceutical Partners Heparin Antagonist Action And Clinical Pharmacology: When administered alone, protamine has an anticoagulant effect. However, when it is given in the presence of heparin (which is strongly acidic), a stable salt is formed which results in the loss of anticoagulant activity of both drugs. Protamine has a rapid onset of action. Neutralization of heparin occurs within 5 minutes after i.v. administration. Although the metabolic fate…

PROPYL-THYRACIL® Frosst Propylthiouracil Hyperthyroidism Therapy Indications And Clinical Uses: The medical management of hyperthyroidism. The treatment of thyrotoxicosis prior to surgery. In conjunction with radioiodine to hasten recovery while awaiting the effects of radiation. The management of thyroid storm in addition to other therapeutic measures. Contra-Indications: Lactation. Hypersensitivity or idiosyncratic reaction to propylthiouracil. Manufacturers’ Warnings In Clinical States: Pregnancy: Propylthiouracil readily crosses the placenta and can cause goiter or cretinism…

Bionutrix Prostanutrix Prostanutrix is a premium designer organic herbal supplement uniquely formulated by Bionutrix physicians to improve and optimize prostate health. This trademark formulation contains a specially balanced organic blend of saw palmetto and pygeum, the only two herbs that have been medically proven to safely and effectively treat and prevent prostate disorders and strengthen libido. Bionutrix is the only company to offer this potent prostate-specific formula in a reliably…

PROMETRIUM™ Schering Progesterone Progestin Action And Clinical Pharmacology: Micronized progesterone is an oral dosage form of the naturally occurring steroid; it is chemically identical to progesterone of ovarian origin. Micronization of progesterone improves its absorption by the digestive tract by increasing the surface area in contact between the steroid and the mucous membrane. Pharmacokinetic studies indicate that plasma progesterone levels within the luteal range are achieved with peak levels at…

PROLEUKIN® Ligand Aldesleukin Antineoplastic Agent Action And Clinical Pharmacology: The exact mechanism by which aldesleukin mediates its anitiumor activity is unknown. Aldesleukin has been shown to possess the biological activity of human native interleukin-2. In vitro studies performed on human cell lines demonstrate the immunoregulatory properties of aldesleukin, including: 1) enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human interleukin-2 dependent cell lines; 2) enhancement of lymphocyte cytotoxicity;…

PRODIEM® PLAIN Novartis Consumer Health Psyllium Bulk Forming Laxative Action And Clinical Pharmacology: Psyllium is a high fiber bulk forming laxative. It absorbs water and expands to provide increased bulk and moisture content to the stool. The increased bulk encourages normal peristalsis and bowel motility. tag_IndicationsIndications Indications And Clinical Uses: The relief of simple, chronic, atonic, and spastic constipation and for constipation associated with pregnancy, convalescence and advanced age. For…

PROGRAF® Fujisawa Tacrolimus Immunosuppressant Action And Clinical Pharmacology: Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. Mechanism of Action: Tacrolimus prolongs the survival of the host and transplanted graft in animal transplant models of liver, kidney, heart, bone marrow, small bowel and pancreas, lung and trachea, skin, cornea and limb. Tacrolimus has been demonstrated to suppress some humoral immunity and, to a greater extent, cell-mediated reactions such as allograft…

PRODIEM® PLUS Novartis Consumer Health Psyllium – Senna Bulk Forming Laxative – Mild Stimulant Action And Clinical Pharmacology: Prodiem Plus is a unique combination of a bulk forming fibre and a mild stimulant. It is a gentle method for the relief of acute and obstinate constipation without harsh chemical laxatives and is often effective in 12 to 24 hours Psyllium is a high fibre bulk forming laxative. It absorbs water…