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ANZEMET™ Hoechst Marion Roussel Dolasetron Mesylate Antiemetic Action And Clinical Pharmacology: Dolasetron and its active metabolite, hydrodolasetron (MDL 74156), are selective 5-HT3 receptor antagonists shown not to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is…

  APO®-ACYCLOVIR Apotex Acyclovir Antiviral Agent Action And Clinical Pharmacology: Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster specified thymidine kinase. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and…

APO®-CEFACLOR Apotex Cefaclor Antibiotic Action And Clinical Pharmacology: Like other b-lactam antibiotics, cefaclor owes its antibacterial activity to its ability to bind to and inhibit the action of certain bacterial cell wall synthetic enzymes, the penicillin-binding proteins. Cefaclor is well absorbed after oral administration to fed and fasted subjects. Following doses of 250 mg, 500 mg, and 1 g to fasted subjects, average peak serum levels of approximately 7, 13…

ANTIBIOTIC COLD SORE OINTMENT Novartis Consumer Health Polymyxin B Compound Cold Sore Therapy Indications And Clinical Uses: Symptomatic treatment of cold sores and fever blisters. Prevention of secondary bacterial infection. Contra-Indications: Hypersensitivity to any of the components. Manufacturers’ Warnings In Clinical States: It is dangerous to apply any product containing menthol or camphor to the nostrils of an infant. To do so may cause difficulty in breathing and collapse. Precautions:…

Antivenin (Latrodectus Mactans) MSD Black Widow Spider Antivenin Indications And Clinical Uses: Used to treat patients suffering from symptoms due to bites from the black widow spider. Early use of the antivenin is emphasized for prompt relief. Manufacturers’ Warnings In Clinical States: Prior to treatment with any product prepared from horse serum, a careful review of the patient’s history should be taken emphasizing prior exposure to horse serum or any…

ANTIVERT™ Pfizer Meclizine HCl – Nicotinic Acid Vertigo Therapy Action And Clinical Pharmacology: Meclizine has antihistaminic and anticholinergic properties. Nicotinic acid is a vasodilator agent which has been found effective in the treatment of vertigo due to cerebral arteriosclerosis. The site and mechanism of action of meclizine in controlling vertigo arising from various conditions, have not been clearly defined. Pharmacological studies conducted with other antihistamines show that the peripheral labyrinthine…

ANBESOL® Preparations Whitehall-Robins Benzocaine Compound Topical Anesthetic Indications And Clinical Uses: Anbesol: For temporary pain relief of toothache, denture irritation, brace pain, minor mouth irritations, cold sores, sun and fever blisters and canker sores. Anbesol Baby: For temporary relief from the pain and irritation associated with teething. Contra-Indications: Anbesol: Known sensitivity to any of the ingredients. Anbesol Baby: Known sensitivity to any of the ingredients. Precautions: Not for prolonged use….

ANACIN® ANACIN® EXTRA STRENGTH Whitehall-Robins ASA – Caffeine Analgesic – Antipyretic – Anti-inflammatory Indications And Clinical Uses: For fast relief of headaches, aches and fever of colds, arthritic and rheumatic pain, toothache and menstrual pain. Contra-Indications: Sensitivity to salicylates, bleeding ulcers and patients with blood coagulation defects, hemophilia, anemia, vitamin K deficiency, renal function impairment, asthma, sensitivity to caffeine and cardiac disease. Manufacturers’ Warnings In Clinical States: All salicylates should…

ANALGESIC BALM Warner-Lambert Consumer Healthcare Menthol – Methyl Salicylate Topical Analgesic Indications And Clinical Uses: For the local treatment of muscular and joint pains. Contra-Indications: Any sensitivity to the components. Precautions: Avoid contact with eyes, mucous membranes or broken skin. Keep out of reach of children. In case of accidental swallowing, seek medical advice. Dosage: Apply by thoroughly rubbing into the skin to promote absorption. To prolong the effect, cover…

ANAFRANIL® Novartis Pharmaceuticals Clomipramine HCl Antidepressant – Antiobsessional Action And Clinical Pharmacology: Clomipramine is a tricyclic agent with both antidepressant and antiobsessional properties. Like other tricyclics, clomipramine inhibits norepinephrine and serotonin uptake into central nerve terminals, possibly by blocking the membrane-pump of neurons, thereby increasing the concentration of transmitter monoamines at receptor sites. Clomipramine is presumed to influence depression and obsessive and compulsive behavior through its effects on serotonergic neurotransmission….