Anacin (ASA – Caffeine)

ANACIN® ANACIN® EXTRA STRENGTH

Whitehall-Robins

ASA – Caffeine

Analgesic – Antipyretic – Anti-inflammatory

Indications And Clinical Uses: For fast relief of headaches, aches and fever of colds, arthritic and rheumatic pain, toothache and menstrual pain.

Contra-Indications: Sensitivity to salicylates, bleeding ulcers and patients with blood coagulation defects, hemophilia, anemia, vitamin K deficiency, renal function impairment, asthma, sensitivity to caffeine and cardiac disease.

Manufacturers’ Warnings In Clinical States: All salicylates should be kept out of reach of children to avoid accidental poisoning. Children and teenagers with influenza or chickenpox should not use this product due to possible association with Reye’s Syndrome.

Precautions: Patients with asthma, allergy to salicylates, blood coagulation problems or receiving anticoagulation therapy, with severe anemia, in the last 3 months of pregnancy or breast-feeding should not take salicylate-containing drugs unless monitored with caution.

Children: Pediatric patients are susceptible to caffeine and its adverse CNS effects.

Drug Interactions: Alcohol and nonsteroidal anti-inflammatory drugs administered with salicylates may increase the potential for gastrointestinal bleeding.

Diabetics under therapy should be monitored if salicylates are administered.

Patients taking valproic acid, furosemide, methotrexate, nifedipine, vancomycin, blood coagulation inhibitors and sulfinpyrazone are not recommended to take salicylates concurrently.

Adverse Reactions: Nausea, vomiting, diarrhea, heartburn, bleeding or irritation of stomach, loss of hearing including ringing or buzzing in the ear, skin rashes, hives or itching, breathing difficulties. Additionally, caffeine may cause nervousness, insomnia, palpitations, vertigo and muscle tremor.

Symptoms And Treatment Of Overdose: Symptoms: Rapid and deep breathing, nausea, vomiting, vertigo, tinnitus, flushing, sweating and thirst. In severe overdose situations patients may have fever, blood in urine, hemorrhage, excitement, confusion, convulsions, coma, breathing difficulties and acid-base disturbances e.g., metabolic acidosis and respiratory alkalosis. CNS stimulation due to caffeine (trouble in sleeping, nervousness or jitters).

Treatment: Induce emesis or perform gastric lavage, then administer activated charcoal. If hyperthermia is present, sponge the patient with tepid water. Maintain appropriate fluid therapy based on the patient’s fluid, acid-base and electrolyte status. Also monitor blood gases, blood glucose, serum creatinine and urea, urinary output and pH. Draw blood for determination of serum salicylate level. Sodium bicarbonate i.v. should be used cautiously to correct metabolic acidosis. Care should be taken to avoid sodium overload or alkalosis. Hypokalemia may require administration of i.v. potassium chloride. If present, hypoglycemia may be managed with dextrose solutions. Seizures may be treated with i.v. diazepam. Alkalinization of the urine to enhance urinary excretion of salicylates may be useful in severe intoxication but should be performed very cautiously in selected patients. Vitamin K may be administered to patients with hemorrhagic complications or prolonged PT. Peritoneal or hemodialysis may be required if serum salicylate concentrations are greater than 6.5 mmol/L 6 hours after ingestion, in complex acid-base disturbances unresponsive to conventional therapy, if the patient is in renal failure, or if the patient is deteriorating clinically despite appropriate care.

Dosage And Administration: Adults: Anacin: 1 or 2 tablets or caplets every 4 hours as required. Do not exceed 12 tablets (caplets) in 24 hours.

Anacin Extra Strength: 1 or 2 tablets or caplets every 4 hours as required. Do not exceed 8 tablets (caplets) in 24 hours.

Availability And Storage: Anacin: Caplets: Each white caplet, printed “Anacin”, contains: ASA 325 mg and caffeine 32 mg. Nonmedicinal ingredients: cellulose, cornstarch, ethoxyethanol, iron oxide, lecithin, pharmaceutical glaze, polyethylene glycol, propylene glycol, simethicone and sodium lauryl sulfate. Energy: 0.18 kJ (0.04 kcal).

Tablets: Each white tablet, embossed “Anacin”, contains: ASA 325 mg and caffeine 32 mg. Nonmedicinal ingredients: cellulose, cornstarch, polyethylene glycol and sodium lauryl sulfate. Energy: 0.18 kJ (0.04 kcal). Tins of 12. Bottles of 30, 50, 100 and 200.

Anacin Extra Strength: Caplets: Each white caplet, printed “Anacin 500”, contains: ASA 500 mg and caffeine 32 mg. Nonmedicinal ingredients: cellulose, cornstarch, ethoxyethanol, iron oxide, lecithin, pharmaceutical glaze, polyethylene glycol, propylene glycol, simethicone and sodium lauryl sulfate. Energy: 0.13 kJ (0.03 kcal).

Tablets: Each white tablet, embossed “Anacin 500”, contains: ASA 500 mg and caffeine 32 mg. Nonmedicinal ingredients: cellulose, cornstarch, polyethylene glycol and sodium lauryl sulfate. Energy: 0.13 kJ (0.03 kcal).

Store at room temperature (15 to 30°C).

Reviewed 1997

ANACIN® ANACIN® EXTRA STRENGTH Whitehall-Robins ASA – Caffeine Analgesic – Antipyretic – Anti-inflammatory

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