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EPIPEN® EPIPEN® JR. Allerex Epinephrine Allergy Therapy Auto-Injector Action And Clinical Pharmacology: Epinephrine is a sympathomimetic drug, acting on both alpha and beta receptors. It is the drug of choice for the emergency treatment of severe allergic reactions to insect bites, insect stings, food, medication and other allergens. It is also indicated for the temporary emergency treatment of severe, life-threatening asthma attacks. The strong vasoconstrictor action of epinephrine acts quickly…

ENTACYL® Roberts Piperazine Adipate Anthelmintic Indications And Clinical Uses: Pinworm or roundworm infestations. Contra-Indications: Impaired renal or hepatic function, convulsive disorders, or a history of hypersensitivity reactions to piperazine or its salts. Precautions: In children, avoid prolonged or repeated treatment in excess of that recommended due to potential neurotoxicity. Pregnancy: Safety of this drug for use during pregnancy has not been established. If CNS, significant gastrointestinal, or hypersensitivity reactions occur,…

ENTEX® LA Purdue Frederick Phenylpropanolamine HCI – Guaifenesin Decongestant – Expectorant Action And Clinical Pharmacology: Phenylpropanolamine is an alpha-adrenergic receptor agonist (sympathomimetic) which produces vasoconstriction by stimulating alpha-receptors within the mucosa of the respiratory tract. Clinically, phenylpropanolamine shrinks swollen mucous membranes, reduces tissue hyperemia, edema and nasal congestion, and increases nasal airway patency. Guaifenesin promotes lower respiratory tract drainage by thinning bronchial secretions, lubricates irritated respiratory tract membranes through increased…

ENTOCORT® Capsules Astra Budesonide Glucocorticosteroid for the Treatment of Crohn’s Disease Affecting the Ileum and/or Ascending Colon Action And Clinical Pharmacology: The active ingredient of Entocort capsules, budesonide, is a potent nonhalogenated synthetic glucocorticosteroid with high topical potency and weak systemic effects. The exact mechanism of action of glucocorticosteroids in the treatment of Crohn’s disease is not fully understood. Anti-inflammatory actions, such as the inhibition of inflammatory mediator release and…

ENTOCORT® Enema Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency. It undergoes an extensive degree (approximately 90%) of biotransformation in the liver to metabolites with low glucocorticosteroid activity. The glucocorticosteroid activity of the major metabolites, 6b-hydroxybudesonide and 16a-hydroxyprednisolone, is less than 1% of that of budesonide. The favorable separation between…

ENFALAC PREGESTIMIL® Mead Johnson Protein Hydrolysate Formula Pediatric Elemental Diet Indications And Clinical Uses: For feeding of infants and children with malabsorption problems which may include: disaccharidase deficiency (relative or absolute), idiopathic defects in digestion or absorption, steatorrhea, cystic fibrosis, food allergies and intestinal resection. Precautions: Patients with lengthy episodes of diarrhea and/or receiving antibiotics may require supplemental vitamin K. In a few instances, premature infants and infants with long-standing…

ENFALAC PROSOBEE® Mead Johnson Soy Protein Isolate Hypoallergenic Product Indications And Clinical Uses: Formula for feeding infants or children with a sensitivity to cow milk protein or a family history of allergies. Symptoms that may require a milk-free source of nutrition include the following: persistent and unexplained eczema, diarrhea, non-specific respiratory disorders, spitting up, and irritability. May be used for adults with food allergies. Precautions: Opened or prepared formula should…

ENLON® Zeneca Edrophonium Chloride Nondepolarizing Neuromuscular Antagonist Action And Clinical Pharmacology: Edrophonium chloride is an anticholinesterase agent which antagonizes the action of nondepolarizing neuromuscular blocking drugs. Edrophonium chloride inactivates the enzyme acetylcholinesterase by combining with it in a reversible manner. The inactivation of the enzyme prevents the hydrolysis of acetylcholine and allows the accumulation of the neurotransmitter. The accumulation of acetylcholine at cholinergic receptor sites leads to the resumption of…

ENGERIX®-B SmithKline Beecham Hepatitis B Vaccine (Recombinant) Vaccine Action And Clinical Pharmacology: Hepatitis B vaccine (recombinant) contains purified hepatitis B surface antigen (HBsAg). It is the product of recombinant DNA technology developed by SmithKline Beecham Biologicals, s.a., Belgium. The HBsAg gene from the hepatitis B virus has been cloned by genetic engineering into Saccharomyces cerevisiae. In vitro experiments have shown that the yeast-derived HBsAg in hepatitis B vaccine (recombinant) contains…

EMLA® Cream/Patch Astra Lidocaine – Prilocaine Topical Anesthetic for Dermal Analgesia Action And Clinical Pharmacology: EMLA (Eutectic Mixture of Local Anesthetics) is a 1:1 oil/water emulsion of a eutectic mixture of lidocaine and prilocaine bases. Dermal analgesia is a result of the migration of lidocaine and prilocaine into the epidermal and dermal layers of the skin followed by the accumulation of these agents in the vicinity of dermal pain receptors…