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ELAVIL PLUS® MSD Amitriptyline HCl – Perphenazine Antidepressant – Neuroleptic Action And Clinical Pharmacology: Elavil Plus exerts the actions of its components. Perphenazine is a potent tranquilizer and also a potent antiemetic. Perphenazine has a nonhypnotic depressant activity on the CNS and is capable of relieving anxiety, tension, psychomotor excitement and other psychotic symptoms. Perphenazine has also widespread effects which include central and peripheral adrenergic blocking effects, anticholinergic action and…

ELAVIL® MSD Amitriptyline HCl Antidepressant Indications And Clinical Uses: In the drug management of depressive illness. Amitriptyline may be used in depressive illness of psychotic or endogenous nature and in selected patients with neurotic depression. Endogenous depression is more likely to be alleviated than are other depressive states. Amitriptyline, because of its sedative action, is also of value in alleviating the anxiety component of depression. As with other tricyclic antidepressants,…

ELDEPRYL® Draxis Health Selegiline HCl Antiparkinsonian Agent Action And Clinical Pharmacology: Selegiline is an irreversible inhibitor of the enzyme monoamine oxidase (MAO). Because selegiline has greater affinity for type B than type A MAO, it can serve as a selective inhibitor of MAO-B if it is administered at the recommended dose. Selegiline may have pharmacological effects unrelated to MAO-B inhibition. There is some evidence that it may increase dopaminergic activity…

EFFEXOR® EFFEXOR® XR Wyeth-Ayerst Venlafaxine HCl Antidepressant Action And Clinical Pharmacology: Venlafaxine is a phenethylamine bicyclic derivative, chemically unrelated to tricyclic, tetracyclic or other available antidepressant agents. The mechanism of venlafaxine’s antidepressant action in humans is believed to be associated with its potentiation of neurotransmitter activity in the CNS. Preclinical studies have shown that venlafaxine and its major metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake…

EDECRIN® SODIUM EDECRIN® MSD Ethacrynic Acid Ethacrynate Sodium Diuretic – Saluretic Action And Clinical Pharmacology: Ethacrynic acid is a saluretic-diuretic agent with marked potency and rapid onset of action. It is chemically unrelated to other diuretics. Patients with congestive heart failure (including acute pulmonary edema), renal edema, hepatic cirrhosis with ascites, and other conditions involving fluid retention have responded well to ethacrynic acid. Ethacrynic acid has the following major characteristics:…

ECHOVIST® Berlex Canada Galactose Ultrasound Contrast Agent Action And Clinical Pharmacology: Echovist is an ultrasound contrast agent consisting of a suspension of micron-sized air bubbles, formed upon reconstitution of specially formulated galactose granules with an aqueous galactose solution. Following intrauterine administration of the suspension, the bubbles serve to enhance ultrasound signals from the uterine cavity and fallopian tubes, thus enabling better visualization of these structures. Upon completion of the ultrasound…

ECOSTATIN® Preparations Westwood-Squibb Econazole Nitrate Antifungal Agent Action And Clinical Pharmacology: Econazole exhibits antifungal activity against a wide variety of fungi, including dermatophytes, pathogenic yeasts, and moulds. Susceptible pathogenic organisms include C. albicans and other Candida species, T. rubrum, T. mentagrophytes, E. floccosum and M. furfur. It appears to act by altering the internal structure or cell membrane permeability of the fungus. tag_IndicationsIndications Indications And Clinical Uses: Cream: The treatment…

DRISTAN® DRISTAN® EXTRA STRENGTH Whitehall-Robins Phenylephrine – Chlorpheniramine – Acetaminophen Decongestant – Antihistamine – Analgesic Indications And Clinical Uses: For the symptomatic relief of colds, sinusitis, hay fever or other upper respiratory allergies, nasal congestion, sneezing, runny nose, fever, headache, minor aches and pains. Contra-Indications: Hypersensitivity to any of the components. Patients receiving MAO inhibitors. Precautions: Use with caution on elderly patients or patients with allergy to acetaminophen, chronic alcoholism,…

DPE™ Alcon Dipivefrin HCl Glaucoma Therapy Action And Clinical Pharmacology: Dipivefrin is converted to epinephrine inside the human eye by enzyme hydrolysis. The liberated epinephrine, an adrenergic agonist, appears to exert its action by decreasing aqueous production and by enhancing outflow facility. The dipivefrin hydrochloride prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine…

DRISTAN® LONG LASTING NASAL MIST/SPRAY Whitehall-Robins Oxymetazoline HCl Nasal Decongestant Action And Clinical Pharmacology: The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. Indications And Clinical Uses: For prompt temporary relief of nasal congestion due to the common cold, sinusitis, hay fever or other upper respiratory allergies for up to 12 hours. Contra-Indications: Narrow angle…