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FLAMAZINE® Smith & Nephew Silver Sulfadiazine Topical Antibacterial Action And Clinical Pharmacology: Silver sulfadiazine is released slowly from the cream, and thus rapid depletion of chloride and associated electrolyte disturbances are minimized. Silver sulfadiazine is not inhibited by PABA. In burned pigs, the absorption of silver was less than 1% of the applied dose, however 5 to 8% of the sulfadiazine was absorbed. There is very little penetration of the…

FASTIN® SmithKline Beecham Phentermine HCl Anorexiant Action And Clinical Pharmacology: Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include CNS stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity are commonly known…

EX-LAX® Chocolated Pieces EX-LAX® Sugar Coated Pills EX-LAX® Extra Strength Sugar Coated Pills Novartis Consumer Health Sennosides Laxative Action And Clinical Pharmacology: Sennosides are a natural source complex of anthraquinone glycosides found in senna. They exert a stimulant laxative effect that increases peristalsis by direct action on the smooth muscle of the intestine. They generally produce bowel movement in 6 to 12 hours. Indications And Clinical Uses: For the overnight…

EUFLEX® Schering Flutamide Nonsteroidal Antiandrogen Action And Clinical Pharmacology: Flutamide demonstrates potent antiandrogenic effects by inhibiting androgen uptake and/or inhibiting nuclear binding of androgen in target tissues. In adult male rats, ventral prostate weights and seminal vesicle weights were markedly reduced by daily administration of flutamide. Indications And Clinical Uses: For use in combination with LHRH agonistic analogues (such as leuprolide acetate) for the treatment of metastatic prostatic carcinoma (Stage…

ETHRANE® Zeneca Enflurane  Inhalation Anesthetic Action And Clinical Pharmacology: Enflurane is an inhalation anesthetic. Induction and recovery from anesthesia with enflurane are rapid. Enflurane does not appear to stimulate excessive salivation or tracheabronchial secretions, or affect bronchomotor tone. Pharyngeal and laryngeal reflexes are readily obtunded. The level of anesthesia changes rapidly, which would be predicted based upon its Oswald partition coefficients. Enflurane reduces ventilation as depth of anesthesia increases. This…

EPHEDRINE HCl Roberts Decongestant Action And Clinical Pharmacology: Ephedrine is an adrenergic drug which exerts peripheral effects resembling those of epinephrine and central effects resembling those of the amphetamines. Ephedrine produces a more sustained action but is less potent than epinephrine. It stimulates both alpha and beta receptors and its peripheral actions are due partly to norepinephrine release and partly to direct effects on receptors. Ephedrine stimulates the heart, elevating…

EPIPEN® EPIPEN® JR. Allerex Epinephrine Allergy Therapy Auto-Injector Action And Clinical Pharmacology: Epinephrine is a sympathomimetic drug, acting on both alpha and beta receptors. It is the drug of choice for the emergency treatment of severe allergic reactions to insect bites, insect stings, food, medication and other allergens. It is also indicated for the temporary emergency treatment of severe, life-threatening asthma attacks. The strong vasoconstrictor action of epinephrine acts quickly…

ENTACYL® Roberts Piperazine Adipate Anthelmintic Indications And Clinical Uses: Pinworm or roundworm infestations. Contra-Indications: Impaired renal or hepatic function, convulsive disorders, or a history of hypersensitivity reactions to piperazine or its salts. Precautions: In children, avoid prolonged or repeated treatment in excess of that recommended due to potential neurotoxicity. Pregnancy: Safety of this drug for use during pregnancy has not been established. If CNS, significant gastrointestinal, or hypersensitivity reactions occur,…

ENGERIX®-B SmithKline Beecham Hepatitis B Vaccine (Recombinant) Vaccine Action And Clinical Pharmacology: Hepatitis B vaccine (recombinant) contains purified hepatitis B surface antigen (HBsAg). It is the product of recombinant DNA technology developed by SmithKline Beecham Biologicals, s.a., Belgium. The HBsAg gene from the hepatitis B virus has been cloned by genetic engineering into Saccharomyces cerevisiae. In vitro experiments have shown that the yeast-derived HBsAg in hepatitis B vaccine (recombinant) contains…

ENFALAC LYTREN® Mead Johnson Oral Electrolyte Solution Electrolyte Replacement Indications And Clinical Uses: Oral administration of electrolyte replacement for infants and children who have experienced electrolyte and fluid loss due to mild or moderate diarrhea and who do not require parenteral therapy. Contra-Indications: Do not use in the presence of severe, continuing diarrhea or other critical fluid losses requiring parenteral fluid therapy; in intractable vomiting, adynamic ileus, intestinal obstruction or…