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GRAMCAL® Novartis Consumer Health Calcium Preparation Calcium Therapy Indications And Clinical Uses: Osteoporosis; conditions requiring supplemental calcium. Contra-Indications: Hypercalcemia and hypercalciuria (e.g., in hyperparathyroidism, vitamin D overdosage, decalcifying tumors such as plasmocytoma, bone metastases); severe renal disease; and in calcium loss due to immobilization. Gramcal is suitable for patients with sodium or potassium restricted diets. Hypersensitivity to any of the components. Precautions: In mild hypercalciuria (exceeding 300 mg/ 24 hours)…

GELUSIL® GELUSIL® EXTRA STRENGTH Warner-Lambert Consumer Healthcare Aluminum Hydroxide – Magnesium Hydroxide Antacid Indications And Clinical Uses: For the temporary relief and treatment of duodenal and stomach ulcers, gastritis, hiatus hernia, esophagitis, heartburn and any similar gastrointestinal disorders in which control of gastric hyperacidity is desirable. Contra-Indications: Should not be given to patients who are severely debilitated or suffering from kidney failure, alkalosis or hypermagnesemia. Precautions: Antacids can interfere with…

GEMZAR® Lilly Gemcitabine HCl Antineoplastic Agent Caution: Gemcitabine is a cytotoxic drug and should be used only by physicians experienced with cancer chemotherapeutic drugs. Prolongation of the infusion time beyond 60 minutes and more frequent than weekly dosing have been shown to increase toxicity. The dosage should be reduced, omitted, or the drug discontinued upon evidence of abnormal suppression of the bone marrow. Acute shortness of breath with a temporal…

GARAMYCIN® Parenteral Schering Gentamicin Sulfate Antibiotic Action And Clinical Pharmacology: Gentamicin is a bactericidal antibiotic which affects bacterial growth by specific inhibition of normal protein synthesis in susceptible bacteria. It is active against a wide variety of pathogenic gram-negative and gram-positive bacteria: P. aeruginosa, Proteus species (both indole-positive and indole-negative), E. coli, K. pneumoniae, E. aerogenes, S. marcescens and Staphylococcus species (including penicillin- and methicillin-resistant strains). In addition, gentamicin sulfate…

GARAMYCIN® Topical Preparations Schering Gentamicin Sulfate Topical Antibiotic Indications And Clinical Uses: For use in the treatment of primary and secondary infections caused by sensitive strains of streptococci (Group A beta-hemolytic, alpha-hemolytic), S. aureus (coagulase positive, coagulase-negative, and some penicillinase producing strains), and the gram-negative bacteria P. aeruginosa, A. aerogenes, E. coli, P. vulgaris, and K. pneumoniae. Primary skin infections that may be expected to respond to treatment with gentamicin…

FUCIDIN® Cream FUCIDIN® Ointment FUCIDIN® Intertulle Leo Fusidic Acid Sodium Fusidate Antibiotic Action And Clinical Pharmacology: Fusidic acid inhibits bacterial protein synthesis by interfering with amino acid transfer from aminoacyl-sRNA to protein on the ribosomes. Fusidic acid may be bacteriostatic or bactericidal depending on inoculum size. Although bacterial cells stop dividing almost within 2 minutes after contact with the antibiotic in vitro, DNA and RNA synthesis continue for 45 minutes…

FLUVIRAL S/F® BioChem Vaccines Whole-Virion and Split-Virion Influenza Virus Vaccine, Inactivated Active Immunizing Agent Action And Clinical Pharmacology: Fluviral S/F, split-virion influenza vaccine, promotes an active immunization against influenza. Within 7 days after injection of the vaccine there is an increase in circulating antibody to the viral hemagglutination, and peripheral blood lymphocytes are primed to respond to in vitro stimulation by vaccine antigens. I.M. injection of inactivated vaccine leads to…

FLUVIRAL® BioChem Vaccines Influenza Virus Vaccine Trivalent, Inactivated Whole-Virion Active Immunizing Agent Action And Clinical Pharmacology: Fluviral whole virion influenza vaccine, promotes an active immunization against influenza. Within 7 days after injection of the vaccine there is an increase in circulating antibody to the viral hemagglutination, and peripheral blood lymphocytes are primed to respond to in vitro stimulation by vaccine antigens. I.M. injection of inactivated vaccine leads to the presence…

FLUDARA® Berlex Canada Fludarabine Phosphate Antineoplastic Action And Clinical Pharmacology: Fludarabine is a fluorinated analog of adenine that is relatively resistant to deamination by adenosine deaminase. Fludarabine (2F-ara-AMP) is rapidly dephosphorylated to 2-fluoro-ara-A (2F-ara-A) and then phosphorylated intracellularly by deoxycytidine kinase to the active 2-fluoro-ara-ATP (2F-ara-ATP). The antitumor activity of this metabolite is the result of inhibition of DNA synthesis via inhibition of ribonucleotide reductase and DNA polymerase a. Maximum…

FLUPHENAZINE General Monograph Antipsychotic Pharmacology: Fluphenazine is a short-acting piperazine phenothiazine. Phenothiazines are thought to elicit their antipsychotic effects via interference with central dopaminergic pathways in the mesolimbic zone of the brain. Extrapyramidal side effects are a result of interaction with dopaminergic pathways in the basal ganglia. Fluphenazine has alpha adrenergic blocking activity and can cause orthostatic hypotension. Compared to other phenothiazines, fluphenazine has weak anticholinergic, sedative and hypotensive activity,…