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IDAMYCIN® Pharmacia & Upjohn Idarubicin HCl Antineoplastic Action And Clinical Pharmacology: Idarubicin, either as a single agent or in combination, has been shown to be a potent antileukemic agent capable of inducing complete remission in previously untreated and in relapsed and refractory acute non-lymphocytic leukemia (ANLL) including resistant patients, and in adult and pediatric relapsed patients with acute lymphoblastic leukemia (ALL). Idarubicin is a DNA-intercalating analog of daunorubicin which has…

HYDRASENSE® NASAL CARE Schering Sea Water Nasal Cleanser Indications And Clinical Uses: Cleanses and relieves excessive mucus accumulation by clearing nasal cavities congested by colds, allergies, sinusitis and rhinitis. It is a simple and effective solution to relieve dry nasal conditions commonly associated with heating or air conditioning systems in homes or airplanes. Precautions: Safe for infants, Hydrasense Baby Mist can be used with confidence without fear of harming delicate,…

HUMULIN® Lilly Insulin, Human Biosynthetic Antidiabetic Agent Action And Clinical Pharmacology: Humulin is a polypeptide hormone consisting of a 21 amino acid A-chain and a 30 amino acid B-chain linked by two disulfide bonds. Humulin is found to be chemically, physically, biologically and immunologically equivalent to pancreatic human insulin which differs slightly from porcine or bovine insulin in amino acid composition. Studies indicate immunogenicity problems with biosynthetic human insulin (BHI)…

HISTAMINE Bioniche Histamine Phosphate Diagnostic Aid Indications And Clinical Uses: To test the ability of the gastric mucosa to produce hydrochloric acid. Contra-Indications: The gastric histamine test is contraindicated in patients with a history of hypersensitivity to histamine products, in patients with hypotension, severe hypertension, vasomotor instability, bronchial asthma (past or present), urticaria (past or present), or severe cardiac, pulmonary or renal disease. Precautions: Attacks of severe asthma or other…

HIVID® Roche Zalcitabine Antiretroviral Agent Action And Clinical Pharmacology: Zalcitabine is a synthetic nucleoside analogue of the naturally occurring nucleoside 2-deoxycytidine in which the 3-hydroxyl group is replaced by hydrogen. Within cells, zalcitabine is converted to the active metabolite, dideoxycytidine 5-triphosphate (ddCTP), by cellular enzymes. ddCTP serves as an alternative substrate to deoxycytidine triphosphate (dCTP) for HIV-reverse transcriptase and inhibits the in vitro replication of HIV-1 by inhibition of viral…

HEXALEN® Lilly Altretamine Antineoplastic Agent Action And Clinical Pharmacology: Altretamine, better known in the scientific literature as hexamethylmelamine (HMM), is a synthetic cytotoxic antineoplastic s-triazine derivative. While altretamine bears structural similarity to, and cross-reactivity with, triethylenemelamine (TEM), a classical alkylating agent, evidence demonstrating altretamine to be an alkylating agent is not conclusive. Altretamine does not consistently demonstrate cross-resistance with classical alkylating agents used in rodent tumors or in human cancer…

HEPALEAN® Organon Teknika Heparin Sodium Anticoagulant Indications And Clinical Uses: Used in the treatment of thrombophlebitis, phlebothrombosis, and cerebral, coronary, and retinal vessel thrombosis to prevent extension of clots and thromboembolic phenomena. Also used prophylactically to prevent the occurrence of thromboembolism, and to prevent clotting during dialysis and other surgical procedures, particularly vascular surgery. When using in conjuction with dialysis machines or where heparin is added to glucose or saline…

HEPARIN: UNFRACTIONATED General Monograph Heparin Sodium Anticoagulant Action And Clinical Pharmacology: Heparin is a heterogeneous preparation of sulfated mucopolysaccharide polymers whose molecular weights range from 3 000 to 30 000 daltons, averaging between 12 000 and 15 000 daltons. Heparin exerts its anticoagulant activity by reversibly binding to antithrombin III (AT III), accelerating the ability of AT III to neutralize thrombin and activated coagulation factor X (Xa). The heparin-AT III…

HAVRIX™ SmithKline Beecham Hepatitis A Vaccine (Inactivated) Active Immunization Agent against infection by Hepatitis A virus Action And Clinical Pharmacology: Hepatitis A vaccine (inactivated) confers immunity against hepatitis A virus (HAV) infection by inducing the production of specific anti-HAV antibodies. In clinical studies involving subjects of 18 to 50 years of age, specific humoral antibodies against HAV were detected in more than 88% of vaccinees at day 15 and 99%…

GYNE-T® Intrauterine Copper Contraceptive Janssen-Ortho Intrauterine Copper Intrauterine Contraceptive Description: The Gyne-T copper intrauterine consists of a polyethylene support in the shape of a “T” (horizontal arm 32 mm in length and 1.59 mm in diameter. The vertical arm is 36 mm in length and 1.52 mm in diameter. The “T” carries 120 mg of copper wire (0.25 mm in diameter; 265 mm in length) wound around the vertical arm…