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NIZORAL® Shampoo McNeil Consumer Products Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and…

NIZORAL® Tablets Janssen-Ortho Ketoconazole Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma membrane….

NIZORAL® Cream Janssen-Ortho Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma…

MULTITEST® CMI Connaught Skin Test Antigens for Cell-Mediated Immunity Diagnostic Aid Action And Clinical Pharmacology: The delayed cutaneous responses associated with the ubiquitous antigens in the Multitest battery appear to be typical cellular hypersensitivity reactions. A relatively small amount of soluble antigen is introduced into the epidermia and superficial dermal tissue by puncture. Circulating T-cells (lymphocytes), sensitized to the antigen from prior contact, react with the antigens in the skin…

MICRO-K EXTENCAPS® MICRO-K-10 EXTENCAPS® Wyeth-Ayerst Microencapsulated Potassium Chloride Potassium Supplement Action And Clinical Pharmacology: Potassium ions participate in a number of physiological processes including the maintenance of intracellular tonicity; the transmission of nerve impulses; the contraction of cardiac, skeletal and smooth muscle; and the maintenance of normal renal function. Depletion may occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate…

MAVIK™ Knoll Trandolapril Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Trandolapril is a nonsulfydryl angiotensin converting enzyme (ACE) inhibitor, which is used in the treatment of mild to moderate essential hypertension and following acute myocardial infarction in stabilized patients with left ventricular dysfunction. Angiotensin converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the pharmacologically active substance, angiotensin II, which is a vasopressor…

LEUKERAN® Glaxo Wellcome Chlorambucil Antineoplastic Agent Action And Clinical Pharmacology: Chlorambucil is an aromatic nitrogen mustard derivative which acts as a bifunctional alkylating agent. Alkylation takes place through the formation of a highly reactive ethylenimonium radical. A probable mode of action involves cross-linkage of the ethylenimonium derivative between two strands of helical DNA and subsequent interference with replication. After oral administration of carbon-14 labelled chlorambucil, maximum plasma radioactivity occurs between…

ISOMIL® Preparations Abbott Milk-Free Formula Nutritional Formula Indications And Clinical Uses: For infants and children with an allergy or sensitivity to cow’s milk. A feeding following diarrhea. A feeding for patients with disorders for which lactose should be avoided: lactase deficiency, lactose intolerance and galactosemia. Precautions: Shake can well before opening. Shake bottle well before feeding. Dosage: The number of mL to be offered to the baby in 24 hours…

ILETIN® ILETIN® II PORK Lilly Insulin Diabetes Mellitus Therapy Description: Insulin is a protein hormone secreted by the beta cells of the pancreatic islets of Langerhans. The administration of suitable doses of insulin to patients with diabetes mellitus, along with controlled diet and exercise, temporarily restores their ability to metabolize carbohydrates, fats and proteins; to store glycogen in the liver; and to convert glucose to fat. When given in suitable…

HYSKON® Medisan Pharmaceuticals Dextran 70 (32% w/v) in Dextrose Hysteroscopy Fluid Indications And Clinical Uses: For use with the hysteroscope as an aid in distending the uterine cavity and in irrigating and visualizing its surfaces. Contra-Indications: Hypersensitivity to dextran. Contraindications relative to the hysteroscopic procedure itself (e.g., pregnancy, endometrial carcinoma). Precautions: When large amounts of Hyskon are employed for hysteroscopy, the possible occurrence of systemic adverse effects including plasma volume…