Dextran 70 (32% w/v) in Dextrose
Indications And Clinical Uses: For use with the hysteroscope as an aid in distending the uterine cavity and in irrigating and visualizing its surfaces.
Contra-Indications: Hypersensitivity to dextran. Contraindications relative to the hysteroscopic procedure itself (e.g., pregnancy, endometrial carcinoma).
Precautions: When large amounts of Hyskon are employed for hysteroscopy, the possible occurrence of systemic adverse effects including plasma volume expansion, transient prolongation of bleeding time and extremely infrequent anaphylactoid reactions should be borne in mind.
Adverse Reactions: To date, few adverse effects directly attributable to the use of Hyskon have been reported. For a description of adverse effects known to occur with i.v. dextran administration, refer to Macrodex monograph.
A low incidence of hypervolemia has been reported following use of large volumes of Hyskon or after infusion at increased pressures.
Dosage And Administration: Dosage is dependent on several factors, such as the type and length of the diagnostic procedure and whether or not manipulation or surgery is performed. The amount of Hyskon instilled into the uterus is usually between 50 and 100 mL.
Introduce Hyskon into the uterine cavity through the cannula of a hysteroscope under low pressure (approx. 100 mm Hg) until the uterus is sufficiently distended to permit adequate visualization. During the hysteroscopic examination, conduct the instillation at a rate that keeps the cavity suitably distended. To avoid uptake of the fluid in the tissues of the uterus and parametria and to avoid having the fluid pass into the peritoneal cavity and backwards along the side of the hysteroscope, do not use pressures greater than 150 mm Hg.
Availability And Storage: Each 100 mL bottle contains: a clear, viscid, sterile, nonpyrogenic solution of dextran 70 (32% w/v) in dextrose (10% w/v).
Hyskon has a tendency to crystallize when subjected to temperature variations or when stored for long periods. If dextran flakes are present, heat at 100 to 110°C until complete dissolution is achieved. Keep from cold during transportation.
HYSKON® Medisan Pharmaceuticals Dextran 70 (32% w/v) in Dextrose Hysteroscopy Fluid