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TARKA® Knoll Trandolapril – Verapamil HCl Antihypertensive Action And Clinical Pharmacology: Tarka is a formulation containing slow-release verapamil, a phenylalkylamine calcium channel blocker, along with immediate-release trandolapril, an angiotensin converting enzyme (ACE) inhibitor. Verapamil is a calcium channel blocker that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and contractile myocardial cells. Verapamil…

STREPTASE® Hoechst Marion Roussel Streptokinase Fibrinolytic Agent Action and Clinical Pharmacology: Streptokinase acts with plasminogen (or plasmin) to produce an “activator complex” that converts residual plasminogen into the proteolytic enzyme, plasmin. Plasmin is capable of hydrolysing fibrin into polypeptides; it also hydrolyses fibrinogen and other plasma proteins. Since plasminogen is present in the thrombus/embolus, activation by streptokinase occurs within the thrombus/embolus as well as on its surface.: The activity of…

SEREVENT DISKUS DESCRIPTION SEREVENT DISKUS (salmeterol xinafoate inhalation powder) contains salmeterol xinafoate as the racemic form of the 1-hydroxy-2-naphthoic acid salt of salmeterol. The active component of the formulation is salmeterol base, a highly selective beta 2 -adrenergic bronchodilator. The chemical name of salmeterol xinafoate is 4-hydroxy-(alpha) 1 -[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol, 1-hydroxy-2-naphthalenecarboxylate. The molecular weight of salmeterol xinafoate is 603.8, and the empirical formula is C 25 H 37 NO 4 C…

RESOURCE® JUST FOR KIDS Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A standard lactose-, gluten- and fiber-free liquid formula designed to meet the nutritional needs of children 1 to 12 years of age with normal gastrointestinal function. Appropriate for both oral or tube feeding use. Precautions: Not for parenteral administration. Not for patients with galactosemia. Dosage And Administration: 1 200 mL or 5 020 kJ (5.1 aseptic Tetra Brik…

PROLEUKIN® Ligand Aldesleukin Antineoplastic Agent Action And Clinical Pharmacology: The exact mechanism by which aldesleukin mediates its anitiumor activity is unknown. Aldesleukin has been shown to possess the biological activity of human native interleukin-2. In vitro studies performed on human cell lines demonstrate the immunoregulatory properties of aldesleukin, including: 1) enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human interleukin-2 dependent cell lines; 2) enhancement of lymphocyte cytotoxicity;…

ORUDIS® ORUDIS® E ORUDIS® SR Rhône-Poulenc Rorer Ketoprofen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Animal pharmacological studies have shown that ketoprofen is a NSAID that possesses anti-inflammatory, analgesic and antipyretic properties. The anti-inflammatory action is not mediated through the pituitary adrenal axis. Its therapeutic effectiveness has been demonstrated by a reduction in joint swelling, pain and duration of morning stiffness, and by increased grip strength and an improvement in…

ORUVAIL® May & Baker Pharma Ketoprofen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Animal pharmacological studies have shown that ketoprofen possesses anti-inflammatory, analgesic and antipyretic properties. The anti-inflammatory action is not mediated through the pituitary adrenal axis. Its therapeutic effectiveness has been demonstrated by a reduction in joint swelling, pain and duration of morning stiffness, and by increased grip strength and an improvement in functional capacity. Clinical trials in patients…

ORTHOCLONE OKT® 3 Janssen-Ortho Muromonab-CD3 Immunosuppressant Action And Clinical Pharmacology: Muromonab-CD3 sterile solution is a murine monoclonal antibody to the T3 (CD3) antigen of human T cells which functions as an immunosuppressant. It is for i.v. use only. The antibody is a biochemically purified IgG2a immunoglobulin with a heavy chain of approximately 50 000 daltons and a light chain of approximately 25 000 daltons. It is directed to a glycoprotein…

ORAFEN® Technilab Ketoprofen Nonsteroidal Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Pharmacological studies in animals have demonstrated that ketoprofen is an NSAID that possesses anti-inflammatory, analgesic and antipyretic properties. The anti-inflammatory action is not mediated through the pituitary adrenal axis. Ketoprofen, like other nonsteroidal anti-inflammatory analgesics is an inhibitor of prostaglandin synthesis. In vivo studies have demonstrated that ketoprofen is 8 times as potent as indomethacin in inhibiting the synthesis…

NIZORAL® Shampoo McNeil Consumer Products Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and…