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DURAGESIC® Janssen-Ortho Fentanyl Opioid Analgesic Action And Clinical Pharmacology: Fentanyl is an opioid analgesic which interacts predominantly with the opioid receptor. Fentanyl produces analgesia, sedation, respiratory depression, constipation, and physical dependence but appears to have less emetic activity than other opioid analgesics. Fentanyl may produce muscle rigidity, miosis, cough reflex suppression, alterations in mood, bradycardia and broncho-constriction. Analgesic blood levels of fentanyl may cause nausea and vomiting directly by stimulating…

DURALITH® Janssen-Ortho Lithium Carbonate Antimanic Agent Action And Clinical Pharmacology: Although lithium is useful for its antimanic effect and in preventing relapses in patients with a clearcut diagnosis of bipolar affective disorder, it has very little, if any, direct effect on moods, normal or abnormal. Lithium alters sodium transport in nerve and muscle cells, effects a shift toward intraneuronal metabolism of catecholamines and has an inhibitory action on the intracellular…

DURICEF™ Bristol Cefadroxil Antibiotic Action And Clinical Pharmacology: Cefadroxil is a cephalosporin with bactericidal activity. In vitro studies have shown that the antibacterial activity of the cephalosporins results from their ability to inhibit mucopeptide synthesis in the bacterial cell wall. Pharmacokinetics: Cefadroxil is well absorbed following oral administration with 93% of a 500 mg dose being recovered unchanged in the urine after 24 hours. Absorption of cefadroxil from the gastrointestinal…

DULCOLAX® Boehringer Ingelheim Self Medication Division Bisacodyl Laxative Indications And Clinical Uses: For the treatment of occasional constipation. In the preparation for diagnostic procedures, in pre- and postoperative treatment, and in conditions which require defecation to be facilitated, the use of bisacodyl must be under medical supervision. Contra-Indications: In patients with ileus, intestinal obstruction, acute surgical abdominal conditions like acute appendicitis, acute inflammatory bowel diseases, and in severe dehydration. Bisacodyl…

DUOFORTE® 27 Stiefel Salicylic Acid Verrucae Therapy Indications And Clinical Uses: For common, plantar and mosaic warts. Contra-Indications: Diabetics or patients with impaired blood circulation should not use this product without the advice of a health professional. Do not use on moles, birthmarks or unusual warts with hair growing from them. Do not use near eyes or mucous membranes. Manufacturers’ Warnings In Clinical States: Do not use on inflamed and/or…

DUOVENT® UDV Boehringer Ingelheim Ipratropium Bromide – Fenoterol Hydrobromide Bronchodilator Action And Clinical Pharmacology: Duovent UDV inhalation solution is a combination of the anticholinergic bronchodilator ipratropium bromide and the beta2-adrenergic bronchodilator fenoterol hydrobromide. Ipratropium is a quaternary ammonium derivative of atropine and is an anticholinergic drug which has bronchodilator properties. On inhalation of ipratropium the onset of action is noted within 5 to 15 minutes with a peak response between…

DUPHALAC® Solvay Pharma Lactulose Crystals Laxative Action And Clinical Pharmacology: Experimental data indicate that lactulose is not significantly absorbed in the small intestine and reaches the colon essentially unchanged. There it is metabolized by bacteria with the formation of low molecular weight acids that acidify the colonic contents. Less than 2% of lactulose is absorbed systemically. Two mechanisms are believed to be involved in the laxative action of lactulose: 1)…

DRIXORAL® DAY/NIGHT Cold Relief System Schering Dexbrompheniramine – Pseudoephedrine Sulfate Antihistamine – Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines or antihistamines. Precautions: Although pseudoephedrine causes practically…

DRIXORAL® NASAL SOLUTION Schering Oxymetazoline HCl Nasal Decongestant Indications And Clinical Uses: The relief of congestion of the nasopharyngeal mucous membranes in a variety of allergic and infectious disorders of the upper respiratory tract, including acute rhinitis and nasopharyngitis; acute and chronic sinusitis; acute and chronic vasomotor rhinitis; perennial allergic rhinitis and seasonal allergic rhinitis (hay fever). Contra-Indications: Narrow angle glaucoma, rhinitis sicca. Concurrent therapy with MAO inhibitors. Hypersensitivity to…

DRIXORAL® N.D. Schering Pseudoephedrine Sulfate Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines or antihistamines. Precautions: Although pseudoephedrine causes practically no pressor effect in normotensive individuals, it…