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DTIC® Bayer Dacarbazine Antineoplastic Agent Action And Clinical Pharmacology: Although dacarbazine’s exact mechanism of action is not known, 3 hypotheses have been offered: 1. inhibition of DNA synthesis by acting as a purine analog. 2. action as an alkylating agent. 3. interaction with SH groups. Dacarbazine is only slightly (approximately 5%) protein bound. Its plasma half-life after i.v. administration is approximately 35 minutes. In animals, approximately 46% of a radio…

CORICIDIN “D”® Schering Chlorpheniramine Maleate – Phenylpropanolamine Compound Antihistaminic – Decongestant – Antipyretic – Analgesic Indications And Clinical Uses: Coricidin “D”: Symptomatic relief of nasal congestion and other discomforts associated with sinusitis, colds and allergic or vasomotor rhinitis. Coricidin “D” Long Acting: For up to 12-hour relief of congestion and sneezing due to colds. Contra-Indications: Sensitivity to any of the components, patients receiving MAO inhibitors in the preceding 3 weeks….

CORICIDIN® NON-DROWSY Schering ASA – Phenylpropanolamine Analgesic – Antipyretic – Decongestant Indications And Clinical Uses: Symptomatic relief of sinus pain and congestion. Contra-Indications: Sensitivity to any of the components, patients receiving MAO inhibitors in the preceding 3 weeks. Precautions: Although phenylpropanolamine causes practically no pressor effect in normotensive individuals, it should be used with caution in patients with hypertension, diabetes, chronic lung disease, latent or clinically recognized angle closure glaucoma,…

DRISTAN® SINUS Whitehall-Robins Ibuprofen – Pseudoephedrine HCl Analgesic – Antipyretic – Nasal Decongestant Action And Clinical Pharmacology: Ibuprofen has exhibited analgesic and antipyretic activity in animal studies designed to specifically demonstrate these effects. Ibuprofen has been shown to have no glucocorticoid-like activity. Pseudoephedrine is an orally effective nasal decongestant when administered in doses of 60 mg/dose, up to 240 mg/day. In order to comply with the flexible dosing schedule approved…

DRIXORAL® DRIXTAB® Schering Dexbrompheniramine Maleate – Pseudoephedrine Sulfate Antihistamine – Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to pressor amines or antihistamines. Children under 12 years of age (sustained…

COREG™ SmithKline Beecham Carvedilol Congestive Heart Failure Agent Action And Clinical Pharmacology: Carvedilol is a cardiovascular agent for the treatment of CHF that combines beta-adrenoceptor blockade and vasodilation in a single racemic mixture. Nonselective beta-adrenoceptor blocking activity is present in the S(-) enantiomer and alpha 1-adrenoceptor blocking activity is present at equal potency in both the R(+) and S(-) enantiomers. Carvedilol has no intrinsic sympathomimetic activity. Its action on beta-receptors…

  CORGARD® Squibb Nadolol Antianginal – Antihypertensive Agent Action And Clinical Pharmacology: Nadolol is a noncardioselective beta-adrenergic blocking agent. It does not possess membrane stabilizing or intrinsic sympathomimetic (partial agonist) activities. The exact mechanism by which the drug exercises its anti-anginal effect is not certain. An important factor may be the reduction of myocardial oxygen requirements by blocking catecholamine-induced increases in heart rate, systolic blood pressure and the velocity and…

CORICIDIN® Cold Tablets Schering Chlorpheniramine – ASA Compound Antihistaminic – Antipyretic – Analgesic Indications And Clinical Uses: For relief of cold and flu symptoms, fever, aches and pains, accompanying a cold, relief of simple headache. Contra-Indications: Sensitivity to any of the components. Precautions: Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics,…

COPHYLAC® Hoechst Marion Roussel Normethadone – p-Hydroxyephedrine HCl Compound Antitussive Indications And Clinical Uses: The treatment of cough associated with inflamed mucosa, which does not respond to products of lesser potency. Cophylac Expectorant is indicated to facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contra-Indications: Do not administer to patients receiving MAO inhibitors. Cophylac Expectorant is contraindicated…

CONRAY® 30 CONRAY® 43 CONRAY® 60 Mallinckrodt Iothalamate Meglumine Radiopaque Medium Action And Clinical Pharmacology: Following intravascular injection, Conray is rapidly transported through the circulatory system to the kidneys and is excreted unchanged in the urine by glomerular filtration. Renal accumulation is sufficiently rapid that maximum radiographic density in the calyces and pelves occurs in most instances about 3 to 8 minutes after injection. In patients with impaired renal function,…