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DELESTROGEN® Squibb Estradiol Valerate Estrogen Indications And Clinical Uses: In nonpregnant women, Delestrogen is indicated in the treatment of amenorrhea (primary and secondary); disturbances of the menstrual cycle (hypomenorrhea, oligomenorrhea, irregular cycles, metrorrhagia); deficiency syndromes (castration, primary ovarian failure, menopause); local manifestations of estrogen deficiency (senile vaginitis, pruritus vulvae); abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology; and for the production of secretory endometrium and…

DDAVP® Tablets Ferring Desmopressin Acetate Antidiuretic Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the antidiuretic hormone, arginine vasopressin, which alters the permeability of the renal tubule to increase resorption of water. The increase in the permeability of both the distal tubules and collecting ducts appears to be mediated by a stimulation of the adenylcyclase activity in the renal tubules. Although the bioavailability of orally ingested desmopressin…

DDAVP® Spray and Rhinyle Nasal Solutions Ferring Desmopressin Acetate Antidiuretic Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the antidiuretic hormone, arginine vasopressin, which alters the permeability of the renal tubule to increase resorption of water. The increase in the permeability of both the distal tubules and collecting ducts appears to be mediated by a stimulation of the adenylcyclase activity in the renal tubules. Approximately 10 to…

DECADRON® Tablets MSD Dexamethasone Corticosteroid Indications And Clinical Uses: Allergic States: Control of severe or incapacitating allergic conditions not responsive to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, drug hypersensitivity reactions. Rheumatic Disorders: as adjunctive therapy for short-term administration during an acute episode or exacerbation of: psoriatic arthritis, rheumatoid arthritis including juvenile rheumatoid arthritis (selected cases may require low-dose…

DECADRON® Phosphate Injection MSD Dexamethasone Sodium Phosphate Corticosteroid Indications And Clinical Uses: By i.v. or i.m. injection when oral therapy is not feasible: Adrenocortical Insufficiency: Dexamethasone sodium phosphate injection has predominantly glucocorticoid activity with low mineralocorticoid activity. Therefore, it does not offer complete replacement therapy, and its use must be supplemented with salt and/or desoxycorticosterone. When so supplemented, dexamethasone sodium phosphate injection is indicated in the impairment of all adrenocortical…

DAUNOXOME® NeXstar Liposomal Daunorubicin Antineoplastic Action And Clinical Pharmacology: DaunoXome is a liposomal preparation of daunorubicin formulated to selectively target daunorubicin to solid tumors in situ. While in the circulation, this formulation protects the entrapped daunorubicin from chemical and enzymatic degradation, minimizes protein binding, and generally decreases uptake by normal tissues, as well as by the non-reticuloendothelial system. The specific mechanism by which DaunoXome is able to deliver daunorubicin to…

DARVON-N® Lilly Propoxyphene Napsylate Analgesic Indications And Clinical Uses: For the relief of mild to moderate pain alone or when it is accompanied by fever. Contra-Indications: Hypersensitivity to any of the components Manufacturers’ Warnings In Clinical States: Do not prescribe propoxyphene for patients who are suicidal or addiction-prone. Prescribe propoxyphene with caution for patients taking tranquilizers or antidepressant drugs and patients who use alcohol in excess. Tell your patients not…

DAYPRO™ Searle Oxaprozin Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Oxaprozin is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. The modes of action of oxaprozin, like that of other nonsteroidal anti-inflammatory agents, are not fully established. It is known, however, that it does inhibit prostaglandin synthesis. Pharmacokinetics: Oxaprozin is almost completely absorbed from the gastrointestinal tract, with peak plasma levels attained 2 to 4 hours after administration. The…

DDAVP® INJECTION Ferring Desmopressin Acetate Antidiuretic Hormone Analogue Action And Clinical Pharmacology: Desmopressin is a synthetic structural analogue of the natural human hormone, arginine vasopressin. As such, it exerts its action on the reabsorption of water in the renal tubule. It also causes a transient increase in all components of the Factor VIII complex and plasminogen activator. These are released very rapidly from their endothelial cell storage sites. Moreover, it…

DALMANE® Roche Flurazepam HCl Hypnotic Action And Clinical Pharmacology: Flurazepam, a benzodiazepine derivative, is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM). Flurazepam decreases sleep latency and number of awakenings for a consequent increase in total sleep time. The duration of hypnotic effect and the profile of unwanted effects may be influenced by the alpha (distribution) and beta (elimination) half-lives…