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COPTIN® Axcan Pharma Sulfadiazine – Trimethoprim Antibacterial Action And Clinical Pharmacology: Tetrahydrofolic acid is an essential metabolic co-factor in the biosynthesis of purines and thymine compounds which are ultimately utilized in the synthesis of DNA and RNA. The amino acids, serine and methionine, also require tetrahydrofolic acid for their biosynthesis. Cotrimazine exerts its antibacterial effect by interfering with 2 consecutive steps in the biosynthesis of tetrahydrofolic acid. Sulfadiazine inhibits bacterial…

CORDARONE® CORDARONE® I.V. Wyeth-Ayerst Amiodarone HCl Antiarrhythmic Agent Action And Clinical Pharmacology: Amiodarone is generally considered a class III antiarrhythmic drug, but it possesses electrophysiologic characteristics of all 4 Vaughan Williams classes. Like Class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, it exerts antisympathetic activity. One of its main effects, with prolonged administration, is to lengthen the cardiac action potential, a class…

COMBIVENT® Inhalation Solution Boehringer Ingelheim Ipratropium Bromide – Salbutamol Sulfate Bronchodilator Action And Clinical Pharmacology: Combivent Inhalation Solution is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the beta2-adrenergic bronchodilator, salbutamol sulfate. Ipratropium bromide is a quaternary ammonium derivative of atropine and is an anticholinergic drug which has bronchodilator properties. On inhalation, the onset of action is noted within 5 to 15 minutes, with a peak response between 1…

COMPLEAT™ MODIFIED Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A blenderized tube feeding formulated from traditional foods including meat, vegetables and fruit for patients with normal gastrointestinal function. Recommended for both short-term and long-term tube feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 6 cans [1 500 mL or 6 700 kJ (1 600 kcal)] provides at least…

COMPLEX 15® Schering Dimethicone – Lecithin Emollient Indications And Clinical Uses: To soothe and relieve dry, sensitive skin. Phospholipid lecithin is a water-binding agent which occurs naturally in the deepest layers of the skin. Each phospholipid molecule forms a complex of 15 water molecules creating a moisture reservoir which restores the skin’s moisture balance. Dosage: Apply as often as needed to the hands, body and face. Availability And Storage: Face…

CONDYLINE™ Canderm Pharma Podofilox Antimitotic Agent Action And Clinical Pharmacology: Necrosis of visible tissue is observed following treatment of genital warts with podofilox. The exact mechanism of action is unknown. Podofilox is believed to exert its antimitotic effect by binding to tubulin, at a site close to but not identical to the binding site of colchicine; it is thought that this antimitotic effect causes necrosis of wart tissue, the observed…

COLY-MYCIN® M PARENTERAL Parke-Davis Sodium Colistimethate Antibiotic Action And Clinical Pharmacology: Sodium colistimethate is the pentasodium salt of the penta (methanesulfonic acid) derivative of colistin. Colistin is a basic polypeptide antibiotic substance produced by the growth of Bacillus polymyxa var. colistinus. Colistin derivatives appear to alter the permeability of the bacterial cytoplasmic membrane, causing leakage of intracellular nucleosides. The drugs are bactericidal in action. I.M. administration of sodium colistimethate with…

COLYTE™ R & C PEG-3350 – Electrolytes Colon Electrolyte Lavage Preparation Action And Clinical Pharmacology: Colyte cleanses the bowel by induction of diarrhea. The osmotic activity of polyethylene glycol 3350, in combination with the electrolyte concentration, results in virtually no net absorption or secretion of ions or water. Accordingly, large volumes may be administered without significant changes in fluid and electrolyte balance. Indications And Clinical Uses: For bowel cleansing prior…

COMBANTRIN® Pfizer Consumer Pyrantel Pamoate Anthelmintic Action And Clinical Pharmacology: Pyrantel exerts its anthelmintic effect by interfering with the neuromuscular function of the parasite. It is also a cholinesterase inhibitor and a ganglionic stimulant. The anthelmintic activity of pyrantel has been demonstrated in several animal models. These tests carried out in mice and dogs showed the compound to be effective against intestinal nematodes representative of those found in humans, such…

COMBIVENT® Inhalation Aerosol Boehringer Ingelheim Ipratropium Bromide – Salbutamol Sulfate Bronchodilator Action And Clinical Pharmacology: Combivent Inhalation Aerosol is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the b2-adrenergic bronchodilator, salbutamol sulfate. Each actuation from the valve delivers 20 µg ipratropium bromide and 120 µg salbutamol sulfate (equivalent to 100 µg salbutamol base). Ipratropium bromide is a quaternary ammonium derivative of atropine and is an anticholinergic with bronchodilator properties….