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HISMANAL® Johnson & Johnson Merck Astemizole Histamine H1-Antagonist Action And Clinical Pharmacology: Astemizole is a potent, long-acting, and selective histamine H1-antagonist. It produces a dose-related inhibition of skin reactions to intradermal histamine. Astemizole inhibits the nose reaction to nasal challenge with histamine and allergens. It inhibits the bronchial reaction to inhaled histamine and allergens in asthmatic patients. Astemizole has extremely weak serotonin antagonism, no anticholinergic properties, antagonism of dopamine and…

HOMATROPINE General Monograph, Mydriatic – Cycloplegic – Anticholinergic Homatropine HBr is a tertiary amine anticholinergic agent used topically to produce mydriasis and cycloplegia. It blocks the responses of the iris sphincter and ciliary muscle to cholinergic stimuli. Homatropine is less potent than atropine and has a shorter duration of action. Complete cycloplegia is not usually attainable. The maximum mydriatic effect occurs in about 10 to 30 minutes, and the maximum…

HIVID® Roche Zalcitabine Antiretroviral Agent Action And Clinical Pharmacology: Zalcitabine is a synthetic nucleoside analogue of the naturally occurring nucleoside 2-deoxycytidine in which the 3-hydroxyl group is replaced by hydrogen. Within cells, zalcitabine is converted to the active metabolite, dideoxycytidine 5-triphosphate (ddCTP), by cellular enzymes. ddCTP serves as an alternative substrate to deoxycytidine triphosphate (dCTP) for HIV-reverse transcriptase and inhibits the in vitro replication of HIV-1 by inhibition of viral…

HIBIDIL® 1:2000 Zeneca Chlorhexidine Gluconate Antiseptic Action And Clinical Pharmacology: Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures. Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus very poorly absorbed. No detectable blood levels have been found in man following oral…

Brand Names: HIBITANE® Skin Cleanser Manufacturer: Zeneca Generic Name: Chlorhexidine Gluconate Use: Antibacterial Skin Cleanser Action And Clinical Pharmacology Chlorhexidine is effective against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. It is inactive against bacterial spores except at elevated temperatures. Because of its cationic nature, chlorhexidine binds strongly to skin, mucosa and other tissues and is thus very poorly absorbed. No detectable blood levels have…

HEPARINS: LOW MOLECULAR WEIGHT General Monograph, Dalteparin Enoxaparin Nadroparin Tinzaparin Anticoagulant Action And Clinical Pharmacology: Low molecular weight heparins (LMWHs) are fragments of heparin produced by enzymatic or chemical depolymerization. They have an average molecular weight of 4 000 to 5 000 daltons (range 1 000 to 10 000 daltons) which is approximately one-third that of standard heparin. Most heparin molecules with molecular weights smaller than 5 400 daltons are…

HEXABRIX® 200 HEXABRIX® 320 Mallinckrodt Ioxaglate Meglumine – Ioxaglate Sodium Radiopaque Medium Action And Clinical Pharmacology: Following intravascular injection, Hexabrix is rapidly transported through the circulatory system to the kidneys and is excreted unchanged in the urine. The pharmacokinetics of intravascularly administered radiopaque contrast media are usually best described by a two compartment model with a rapid alpha phase for drug distribution and a slower beta phase for drug elimination….

HEXADROL® PHOSPHATE INJECTION Organon Teknika Dexamethasone Sodium Phosphate Corticosteroid Action And Clinical Pharmacology: After administration of the injection, dexamethasone sodium phosphate is rapidly converted into dexamethasone. This is a synthetic glucocorticoid which has 7 times the anti-inflammatory potency of prednisolone. Like other glucocorticoids, dexamethasone also has antiallergic, antitoxic, antishock, antipyretic and immunosuppressive properties. Dexamethasone has practically no water and salt-retaining properties and is, therefore, particularly suitable for use in patients…

HEXALEN® Lilly Altretamine Antineoplastic Agent Action And Clinical Pharmacology: Altretamine, better known in the scientific literature as hexamethylmelamine (HMM), is a synthetic cytotoxic antineoplastic s-triazine derivative. While altretamine bears structural similarity to, and cross-reactivity with, triethylenemelamine (TEM), a classical alkylating agent, evidence demonstrating altretamine to be an alkylating agent is not conclusive. Altretamine does not consistently demonstrate cross-resistance with classical alkylating agents used in rodent tumors or in human cancer…

HEALON® HEALON® GV Pharmacia & Upjohn Sodium Hyaluronate Ophthalmosurgical Aid Description: Sodium hyaluronate is a sterile, nonpyrogenic, viscoelastic preparation of a highly purified, noninflammatory, high molecular weight fraction of sodium hyaluronate. Healon contains 10 mg/mL of sodium hyaluronate 5 000 and Healon GV contains 14 mg/mL of sodium hyaluronate 7 000 dissolved in physiological sodium chloride-phosphate buffer (pH 7.0 to 7.5). This high molecular weight polymer is made up of…