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HEPALEAN® Organon Teknika Heparin Sodium Anticoagulant Indications And Clinical Uses: Used in the treatment of thrombophlebitis, phlebothrombosis, and cerebral, coronary, and retinal vessel thrombosis to prevent extension of clots and thromboembolic phenomena. Also used prophylactically to prevent the occurrence of thromboembolism, and to prevent clotting during dialysis and other surgical procedures, particularly vascular surgery. When using in conjuction with dialysis machines or where heparin is added to glucose or saline…

HEPARIN LEO® Leo Heparin Sodium Anticoagulant Action And Clinical Pharmacology: Heparin is an anticoagulant which prevents the formation of thrombin by accelerating the neutralization of activated coagulation factors by naturally occurring inhibitors. Indications And Clinical Uses: For the prophylaxis and management of intravascular clotting and embolism in susceptible patients. It is also used in extra-corporeal circulation, i.e. heart-lung and renal dialysis machines and blood transfusions. Contra-Indications: Hemorrhagic disorders and patients…

HEPARIN: UNFRACTIONATED General Monograph Heparin Sodium Anticoagulant Action And Clinical Pharmacology: Heparin is a heterogeneous preparation of sulfated mucopolysaccharide polymers whose molecular weights range from 3 000 to 30 000 daltons, averaging between 12 000 and 15 000 daltons. Heparin exerts its anticoagulant activity by reversibly binding to antithrombin III (AT III), accelerating the ability of AT III to neutralize thrombin and activated coagulation factor X (Xa). The heparin-AT III…

HALOG® Preparations Westwood-Squibb Halcinonide Topical Corticosteroid Indications And Clinical Uses: Halcinonide, a synthetic fluorinated corticosteroid, is indicated for topical application for the relief of the inflammatory manifestations of acute or chronic corticosteroid responsive dermatoses; under occlusion, in the management of recalcitrant cases of psoriasis and neurodermatitis. Contra-Indications: Tuberculous, fungal and most viral lesions of the skin (including herpes simplex, vaccinia, and varicella). Patients with history of hypersensitivity to any of…

HALFAN™ SmithKline Beecham Halofantrine HCl Antimalarial Action And Clinical Pharmacology: Halofantrine is schizonticidal and exerts its action at the erythrocytic stage of the life cycle (trophozoite and schizont). It is not effective against exo-erythrocytic (hepatic) schizonts or against the sporozoite, merozoite or gametozoite stages of the life cycle of Plasmodium species investigated. The precise mechanism of action of halofantrine is not certain. It has been hypothesized that halofantrine interferes with…

HALOTESTIN® Pharmacia & Upjohn Fluoxymesterone Androgenic – Anabolic Steroid Action And Clinical Pharmacology: Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body…

HAVRIX™ SmithKline Beecham Hepatitis A Vaccine (Inactivated) Active Immunization Agent against infection by Hepatitis A virus Action And Clinical Pharmacology: Hepatitis A vaccine (inactivated) confers immunity against hepatitis A virus (HAV) infection by inducing the production of specific anti-HAV antibodies. In clinical studies involving subjects of 18 to 50 years of age, specific humoral antibodies against HAV were detected in more than 88% of vaccinees at day 15 and 99%…

HABITROL® Novartis Consumer Health Nicotine Smoking Cessation Aid Action And Clinical Pharmacology: Habitrol delivers S(-)-nicotine, the active component of tobacco smoke, transdermally into the systemic circulation, continuously over 24 hours. Habitrol releases S(-)-nicotine in controlled amounts at a rate sufficient to produce plasma nicotine concentrations comparable to trough levels observed in smokers before smoking a cigarette. Because of the low, continuous delivery of S(-)-nicotine through the skin, Habitrol does not…

HALCION® Pharmacia & Upjohn Triazolam Hypnotic Action And Clinical Pharmacology: Triazolam is a benzodiazepine hypnotic with a very short elimination half-life (about 3 hours). In sleep laboratory studies of 1 to 21 days duration, triazolam significantly decreased sleep latency, increased duration of sleep and decreased the number of nocturnal awakenings. However, after 2 weeks of consecutive nightly administration, the drug’s effect on total wake time was decreased, and the values…

HALDOL® LA Janssen-Ortho Haloperidol Decanoate Antipsychotic Action And Clinical Pharmacology: Haloperidol decanoate, an ester derivative of haloperidol obtained from condensation of haloperidol with decanoic acid possesses the antipsychotic properties of haloperidol. When it is administered as an i.m. depot in sesame oil, esterases present in blood and tissues hydrolyze haloperidol decanoate to provide a slow release of the active neuroleptic haloperidol from the depot into the systemic circulation. The onset…