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HYDRASENSE® NASAL CARE Schering Sea Water Nasal Cleanser Indications And Clinical Uses: Cleanses and relieves excessive mucus accumulation by clearing nasal cavities congested by colds, allergies, sinusitis and rhinitis. It is a simple and effective solution to relieve dry nasal conditions commonly associated with heating or air conditioning systems in homes or airplanes. Precautions: Safe for infants, Hydrasense Baby Mist can be used with confidence without fear of harming delicate,…

HUMEGON® Organon Human Gonadotropin Human Gonadotropins Action And Clinical Pharmacology: Humegon (human gonadotropin) is a purified preparation of gonadotropins extracted from the urine of post menopausal and pregnant women. It contains follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are necessary for the normal gamete maturation (follicle ripening in the female and spermatogenesis in the male) and for gonadal steroid production. Unlike menotropins, human gonadotropin is standardized with…

HUMULIN® Lilly Insulin, Human Biosynthetic Antidiabetic Agent Action And Clinical Pharmacology: Humulin is a polypeptide hormone consisting of a 21 amino acid A-chain and a 30 amino acid B-chain linked by two disulfide bonds. Humulin is found to be chemically, physically, biologically and immunologically equivalent to pancreatic human insulin which differs slightly from porcine or bovine insulin in amino acid composition. Studies indicate immunogenicity problems with biosynthetic human insulin (BHI)…

HYCAMTIN™ SmithKline Beecham Topotecan HCl Antineoplastic Action And Clinical Pharmacology: Topotecan inhibits topoisomerase-I, an enzyme that functions in DNA replication to relieve the torsional strain introduced ahead of the moving replication fork. Topotecan inhibits topoisomerase-I by stabilizing the covalent complex of enzyme and strand-cleaved DNA which is an intermediate of the catalytic mechanism, thereby inducing breaks in the protein-associated DNA single-strands, resulting in cell death. Pharmacokinetics: Following i.v. administration of…

HYCODAN® DuPont Pharma Hydrocodone Bitartrate Antitussive Action And Clinical Pharmacology: Clinical trials have proven hydrocodone bitartrate to be an effective antitussive agent which is pharmacologically 2 to 8 times as potent as codeine. At equi-effective doses, its sedative action is greater than that of codeine. The precise mechanisms of action of hydrocodone and other opiates are not known; however, hydrocodone is believed to act by directly depressing the cough centre….

HONVOL® Carter Horner Diethylstilbestrol Diphosphate Prostatic Carcinoma Therapy Indications And Clinical Uses: For intensive and selective palliative therapy of inoperable prostatic carcinoma. Contra-Indications: Patients with active hepatic dysfunction or disease, especially of the obstructive type; a personal history of breast cancer, except in special circumstances; a history of cerebrovascular accident, coronary thrombosis or the presence of classical migraine; a history of thrombophlebitis or thromboembolic disease; partial or complete loss of…

HUMALOG™ Lilly Insulin Lispro Antidiabetic Agent Action And Clinical Pharmacology: Insulin lispro is a rapid-acting analogue of human insulin. Due to its quick onset of action, insulin lispro should be given within 15 minutes of a meal. Insulin lispro is created by inverting the natural Pro-Lys sequence in human insulin at positions 28 and 29 in the C terminal portion of the B-chain. This change in amino acid sequence slightly…

HUMATROPE® Lilly Somatropin Growth Stimulant Action And Clinical Pharmacology: Somatropin is a polypeptide hormone of recombinant DNA origin. The amino acid sequence is identical to that of human growth hormone of pituitary origin. Somatropin is synthesized in a strain of E. coli which has been modified by the addition of the gene for human growth hormone. Somatropin stimulates linear growth in pediatric patients lacking adequate normal endogenous growth hormone. Treatment…

HUMATIN™ Parke-Davis Paromomycin Sulfate Antibiotic Action And Clinical Pharmacology: Paromomycin is a broad spectrum aminoglycoside antibiotic produced by S. rimosus var. paromomycinus. The drug is structurally related to neomycin, streptomycin and kanamycin. It is poorly absorbed after oral administration with almost 100% of the drug recoverable in the stool. Paromomycin is considered a luminal or contact amebicide since it acts principally in the intestinal lumen. Unlike tetracyclines, paromomycin is a…

HISTAMINE Bioniche Histamine Phosphate Diagnostic Aid Indications And Clinical Uses: To test the ability of the gastric mucosa to produce hydrochloric acid. Contra-Indications: The gastric histamine test is contraindicated in patients with a history of hypersensitivity to histamine products, in patients with hypotension, severe hypertension, vasomotor instability, bronchial asthma (past or present), urticaria (past or present), or severe cardiac, pulmonary or renal disease. Precautions: Attacks of severe asthma or other…