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HYTRIN® Abbott Terazosin HCl Antihypertensive – Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH) Action And Clinical Pharmacology: Hypertension: The antihypertensive effect of terazosin is believed to be a direct result of peripheral vasodilation. Although the exact mechanism by which the lowering of blood pressure is achieved is not known, the relaxation of the vessels appears to be produced mainly by selective blockade of alpha-1-adrenoceptors. Benign Prostatic Hyperplasia (BPH): The reduction…

HYDROPRES®-25 MSD Hydrochlorothiazide – Reserpine Diuretic – Antihypertensive Indications And Clinical Uses: Fixed-dose combination drugs are not indicated for initial therapy. Patients should be titrated on the individual drugs. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. If during maintenance therapy dosage adjustment is necessary it is advisable to use the individual drugs. In many cases of hypertension, Hydropres-25 alone…

HYDROMORPH CONTIN® Purdue Frederick Hydromorphone HCl Opioid Analgesic Action And Clinical Pharmacology: Hydromorphone, a semi-synthetic opioid agonist, is a hydrogenated ketone of morphine and shares the pharmacologic properties typical of opioid analgesics. Hydromorphone and related opioids produce their major effects on the CNS and gastrointestinal tract. These include analgesia, drowsiness, mental clouding, changes in mood, euphoria or dysphoria, respiratory depression, cough suppression, decreased gastrointestinal motility, nausea, vomiting, increased cerebrospinal fluid…

HYGROTON® Novartis Pharmaceuticals Chlorthalidone Diuretic – Antihypertensive Action And Clinical Pharmacology: Chlorthalidone inhibits reabsorption of sodium and chloride in the distal renal tubule thus promoting water loss. The higher urine volume increases potassium loss. Little information is available on the absorption of the drug. Its long elimination half-life and clinical experience place it as a long-acting thiazide derivative. This may not be important clinically because the biological effects of thiazides…

HYPAQUE® PARENTERAL Nycomed Imaging A.S. Diatrizoate Sodium – Diatrizoate Meglumine Contrast Media Action And Clinical Pharmacology: When injected into the chambers of the heart or into blood vessels, diatrizoate sodium and diatrizoate meglumine opacify their lumina, then they are rapidly carried via the bloodstream to the kidneys, where they are excreted unchanged mainly by glomerular filtration, permitting radiographic visualization of opacified heart chambers, blood vessels and the urinary tract. Administration…

HYDREA® Squibb Hydroxyurea Antineoplastic Agent Action And Clinical Pharmacology: Neoplastic Disease. The precise mechanism by which hydroxyurea produces its antineoplastic effects cannot, at present, be described. However, the reports of various studies in rat and human tissue cultures lend support to the hypothesis that hydroxyurea causes an immediate inhibition of DNA synthesis, by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or of protein….

HYDROCHLOROTHIAZIDE General Monograph, Diuretic – Antihypertensive Pharmacology: Hydrochlorothiazide inhibits reabsorption of sodium and chloride in the distal tubule thus promoting water loss. The higher urine volume increases potassium loss; this loss can often be decreased by restricting sodium intake. Oral doses are well absorbed and reach peak effect in about 4 hours, with a 6 to 12 hour duration. It is excreted unchanged in the urine with a half-life of…

HydroDIURIL® MSD Hydrochlorothiazide Diuretic – Antihypertensive Action And Clinical Pharmacology: Hydrochlorothiazide is a diuretic and antihypertensive. Hydrochlorothiazide interferes with the renal tubular mechanism of electrolyte reabsorption. It increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium, magnesium and bicarbonate. Urinary calcium excretion may be decreased. While this compound is predominantly a saluretic agent, in vitro studies have shown that it…

HYCOMINE® HYCOMINE®-S DuPont Pharma Hydrocodone Compound Antitussive – Antihistaminic – Decongestant Action And Clinical Pharmacology: See Hycodan for pharmacology of hydrocodone. Pyrilamine maleate is a competitive H1-receptor histamine-blocking drug, thereby counteracting the effects of histamine release associated with allergic manifestations of upper respiratory tract inflammatory disorders. H1-blocking drugs inhibit the actions of histamine on smooth muscle, capillary permeability, and can both stimulate and depress the CNS. Phenylephrine HCl effects its…

HYDERGINE® Novartis Ergoloid Mesylates Adjunctive Management of Idiopathic Dementia Action And Clinical Pharmacology: The possible mechanism of action of ergoloid mesylates has not been determined. There is no evidence that ergoloid mesylates affect cerebrovascular insufficiency or cerebral arteriosclerosis. Ergoloid mesylates do not have the vasoconstrictor effects of the natural ergot alkaloids. Indications And Clinical Uses: May be of some value in the adjunctive management of selective symptoms of elderly patients…