Humatin (Paromomycin)



Paromomycin Sulfate


Action And Clinical Pharmacology: Paromomycin is a broad spectrum aminoglycoside antibiotic produced by S. rimosus var. paromomycinus. The drug is structurally related to neomycin, streptomycin and kanamycin.

It is poorly absorbed after oral administration with almost 100% of the drug recoverable in the stool.

Paromomycin is considered a luminal or contact amebicide since it acts principally in the intestinal lumen. Unlike tetracyclines, paromomycin is a direct-acting amebicide and is effective either in the presence or absence of bacteria.

Like other aminoglycosides, paromomycin is bactericidal and appears to inhibit protein synthesis in susceptible bacteria at the 30S segment of the ribosome.

Paromomycin has a broad spectrum of activity, including activity against protozoa, bacteria and cestodes. Paromomycin is active against protozoa, especially E. histolytica. The drug is believed to act against both the trophozoite and encysted forms of Entamoeba.

Paromomycin has an antibacterial spectrum quite similar to that of neomycin and is bactericidal to many normal and pathogenic organisms in the gastrointestinal tract. Almost complete cross-resistance exists between paromomycin and kanamycin, neomycin and streptomycin.

Indications And Clinical Uses: For intestinal amebiasis, acute and chronic. It is not effective in extraintestinal amebiasis.

Contra-Indications: Individuals with a history of previous hypersensitivity reactions to paromomycin. It is also contraindicated in intestinal obstruction.

Precautions: The use of this antibiotic, as with other antibiotics, may result in an overgrowth of nonsusceptible organisms, including fungi. Constant observation of the patient is essential. If new infections caused by nonsusceptible organisms appear during therapy, appropriate measures should be taken.

The drug should be used with caution in individuals with ulcerative lesions of the bowel to avoid renal toxicity through inadvertent absorption.

Adverse Reactions: Nausea, abdominal cramps and diarrhea have been reported in patients on doses over 3 g daily. tag_DosageDosage

Dosage: Adults and Children: Usual dose 25 to 35 mg/kg body weight daily, administered in 3 doses with meals, for 5 to 10 days.

Availability And Storage: Each capsule contains: paromomycin sulfate equivalent to paromomycin 250 mg. Nonmedicinal ingredients: capsule shell: D&C yellow No. 10, FD&C blue No. 1, FD&C red No. 3, FD&C yellow No. 6, gelatin and titanium dioxide. Bottles of 100. Store at controlled room temperature 15 to 30°C. Protect from moisture.

HUMATIN™ Parke-Davis Paromomycin Sulfate Antibiotic

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