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ImmuCyst® Connaught Bacillus Calmette-Guerin (BCG), substrain Connaught Antineoplastic Action And Clinical Pharmacology: When administered intravesically as a cancer therapy, BCG promotes a local acute inflammatory and sub-acute granulomatous reaction with histiocytic and leukocytic infiltration in the urothelium and lamina propria of the urinary bladder. The local inflammatory effects are associated with an elimination or reduction of superficial cancerous lesions of the urinary bladder. The antitumor effect appears to be T-lymphocyte-dependent….

IMITREX® Injection/Tablets IMITREX® Nasal Spray Glaxo Wellcome Sumatriptan Succinate Sumatriptan Migraine Therapy Action And Clinical Pharmacology: Sumatriptan has been shown to be effective in relieving migraine headache. It is an agonist for a vascular 5-hydroxytryptamine1D (5-HT1D) receptor subtype (a member of the 5-HT1 family), and has only weak affinity for 5-HT1A receptors and no significant activity (as measured using standard radioligand binding assays) or pharmacological activity at 5-HT2, 5-HT3, 5-HT4,…

IMMUNINE® VH Baxter Factor IX Concentrate (Human) Blood Coagulation Factor Action And Clinical Pharmacology: Coagulation factor IX is one of the clotting factors found in normal human blood and is required for normal clot formation. I.V. administration of Immunine VH, factor IX concentrate (human) vapor heated, Immuno provides an increase in plasma levels of factor IX and can temporarily correct the coagulation defect of patients with factor IX deficiency. The…

IFEX® Bristol Ifosfamide Antineoplastic Agent Caution: Ifosfamide is a potent drug and should be used only by physicians experienced with cancer chemotherapeutic drugs (see Warnings and Precautions). In those patients who develop bacterial, fungal or viral infections, interruption or modification of dosage should be considered. Blood counts should be taken at regular intervals. Due to the urotoxic effect of oxazaphosphorines, ifosfamide should not be administered without the use of a…

ILOSONE® Lilly Erythromycin Estolate Antibiotic Action And Clinical Pharmacology: Erythromycin exerts its antibacterial action by binding the 50S ribosomal subunit of susceptible bacteria and suppressing protein synthesis. Erythromycin is usually bacteriostatic but may be bactericidal in high concentrations or against highly susceptible organisms. Indications And Clinical Uses: For the treatment of infections caused by susceptible strains of the designated microorganisms in the diseases listed below: Upper respiratory tract infections of…

IMDUR® Astra Isosorbide-5-Mononitrate Antianginal Action And Clinical Pharmacology: As with other organic nitrates, the principal pharmacological action of isosorbide-5-mononitrate, the major active metabolite of isosorbide dinitrate (ISDN), is relaxation of vascular smooth muscle and consequent dilation of peripheral arteries and veins, especially the latter. Dilation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge…

HYZAAR® MSD Losartan Potassium – Hydrochlorothiazide Angiotensin II Receptor Antagonist – Diuretic Action And Clinical Pharmacology: Hyzaar combines the actions of losartan potassium, an angiotensin II receptor antagonist, and that of a thiazide diuretic, hydrochlorothiazide. Losartan: Losartan antagonizes angiotensin II by blocking the angiotensin type 1 (AT1) receptor. Angiotensin II is the primary vasoactive hormone of the renin-angiotensin system. Its effects include vasoconstriction and the stimulation of aldosterone secretion by…

IDAMYCIN® Pharmacia & Upjohn Idarubicin HCl Antineoplastic Action And Clinical Pharmacology: Idarubicin, either as a single agent or in combination, has been shown to be a potent antileukemic agent capable of inducing complete remission in previously untreated and in relapsed and refractory acute non-lymphocytic leukemia (ANLL) including resistant patients, and in adult and pediatric relapsed patients with acute lymphoblastic leukemia (ALL). Idarubicin is a DNA-intercalating analog of daunorubicin which has…

IDARAC® Sanofi Floctafenine Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Floctafenine, an anthranilic acid derivative, is a nonsteroidal anti-inflammatory agent with analgesic and anti-inflammatory properties. The analgesic activity is comparable to that of other mild analgesics in the relief of acute pain. Floctafenine has been shown to inhibit in vitro biosynthesis of prostaglandins PGE2 and PGF2a. Gastrointestinal bleeding determined by daily fecal blood loss, was shown in one clinical trial…

HYPERSTAT® I.V. INJECTION Schering Diazoxide Antihypertensive Action And Clinical Pharmacology: Diazoxide injection produces a prompt reduction in blood pressure by relaxing smooth muscle in the peripheral arterioles. Cardiac output is increased as blood pressure is reduced by diazoxide; coronary and cerebral blood flow are maintained. Renal blood flow is increased after an initial decrease. Diazoxide has no known direct action on the CNS. Patients refractory to other antihypertensive agents usually…