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ANECTINE® Glaxo Wellcome Succinylcholine Chloride Neuromuscular Blocking Agent Action And Clinical Pharmacology: Succinylcholine is an ultra short-acting depolarizing-type, skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Onset of flaccid paralysis is rapid, (less than…

ANEXATE® Roche Flumazenil Benzodiazepine Antagonist Action And Clinical Pharmacology: Flumazenil, an imidazobenzodiazepine, is a benzodiazepine antagonist which blocks the central effects of agents that act via the benzodiazepine receptor, by competitive inhibition. The antagonism is specific, since in animal experiments the effects of compounds which have no affinity for the benzodiazepine receptor (e.g., barbiturates, meprobamate, ethanol, GABA-mimetics, and adenosine receptor agonists) were not affected by flumazenil. Following the i.v. administration…

ANANDRON® Hoechst Marion Roussel Nilutamide Nonsteroidal Antiandrogen Action And Clinical Pharmacology: Nilutamide is a pure, nonsteroidal antiandrogen which blocks androgens binding at receptor target cells. Nilutamide is specific and does not bind to any other steroidal receptors; therefore, it does not have any other hormonal or antihormonal activity. Nilutamide demonstrates potent antiandrogenic effects by inhibiting androgen uptake and/or inhibiting nuclear binding of androgen in target tissues. In adult male rats,…

ANAPROX® ANAPROX® DS Roche Naproxen Sodium Analgesic – Anti-inflammatory Action And Clinical Pharmacology: Naproxen sodium, has demonstrated analgesic, anti-inflammatory and antipyretic properties in human clinical studies and in classical animal test systems. It exhibits an anti-inflammatory effect even in adrenalectomized animals and therefore its action is not mediated through the pituitary-adrenal axis. It is not a corticosteroid. It inhibits prostaglandin synthetase, as do certain other nonsteroidal analgesic/anti-inflammatory agents. As with…

ANCEF® SmithKline Beecham Cefazolin Sodium Antibiotic Action And Clinical Pharmacology: Cefazolin sodium is a cephalosporin antibiotic for parenteral administration. It exerts its bactericidal action through inhibition of bacterial cell wall synthesis. Indications And Clinical Uses: In the treatment of the following infections when caused by susceptible strains of the following organisms: Respiratory tract infections caused by S. pneumoniae (formerly D. pneumoniae), K. pneumoniae, H. influenzae, S. aureus (penicillin-sensitive and penicillin-resistant)…

ANBESOL® Preparations Whitehall-Robins Benzocaine Compound Topical Anesthetic Indications And Clinical Uses: Anbesol: For temporary pain relief of toothache, denture irritation, brace pain, minor mouth irritations, cold sores, sun and fever blisters and canker sores. Anbesol Baby: For temporary relief from the pain and irritation associated with teething. Contra-Indications: Anbesol: Known sensitivity to any of the ingredients. Anbesol Baby: Known sensitivity to any of the ingredients. Precautions: Not for prolonged use….

ANACIN® ANACIN® EXTRA STRENGTH Whitehall-Robins ASA – Caffeine Analgesic – Antipyretic – Anti-inflammatory Indications And Clinical Uses: For fast relief of headaches, aches and fever of colds, arthritic and rheumatic pain, toothache and menstrual pain. Contra-Indications: Sensitivity to salicylates, bleeding ulcers and patients with blood coagulation defects, hemophilia, anemia, vitamin K deficiency, renal function impairment, asthma, sensitivity to caffeine and cardiac disease. Manufacturers’ Warnings In Clinical States: All salicylates should…

ANALGESIC BALM Warner-Lambert Consumer Healthcare Menthol – Methyl Salicylate Topical Analgesic Indications And Clinical Uses: For the local treatment of muscular and joint pains. Contra-Indications: Any sensitivity to the components. Precautions: Avoid contact with eyes, mucous membranes or broken skin. Keep out of reach of children. In case of accidental swallowing, seek medical advice. Dosage: Apply by thoroughly rubbing into the skin to promote absorption. To prolong the effect, cover…

ANAFRANIL® Novartis Pharmaceuticals Clomipramine HCl Antidepressant – Antiobsessional Action And Clinical Pharmacology: Clomipramine is a tricyclic agent with both antidepressant and antiobsessional properties. Like other tricyclics, clomipramine inhibits norepinephrine and serotonin uptake into central nerve terminals, possibly by blocking the membrane-pump of neurons, thereby increasing the concentration of transmitter monoamines at receptor sites. Clomipramine is presumed to influence depression and obsessive and compulsive behavior through its effects on serotonergic neurotransmission….

ANA-KIT® Bayer Epinephrine – Chlorpheniramine Maleate Allergy Therapy Action And Clinical Pharmacology: Epinephrine: The most valuable drug for the emergency treatment of severe allergic reactions is epinephrine. The vasoconstrictor effect of epinephrine on the capillary directly antagonizes the generalized vasodilation produced by histamine. Epinephrine reverses the increased permeability of dilated capillaries to plasma. The shock of severe allergic reactions is due to the loss of circulating blood volume by pooling…