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AQUAPHOR® Smith & Nephew Petrolatum Dermatological Base Indications And Clinical Uses: A neutral, anhydrous base for compounding smooth, stable emulsions; highly miscible with both aqueous solutions and other oil-based substances. For severely dry skin. Also helps promote healing of minor skin irritations. Precautions: For external use only. Avoid contact with eyes. If this occurs, rinse thoroughly with water. If rash or irritation occurs or worsens, discontinue use and consult a…

APO®-TERAZOSIN Apotex Terazosin HCl Antihypertensive Agent – Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH) Action And Clinical Pharmacology: Hypertension: The antihypertensive effect of terazosin is believed to be a direct result of peripheral vasodilation. Although the exact mechanism by which the lowering of blood pressure is achieved is not known, the relaxation of the vessels appears to be produced mainly by selective blockade of a1-adrenoceptors. Benign Prostatic Hyperplasia (BPH): The…

APRESOLINE® Novartis Pharmaceuticals Hydralazine HCl Antihypertensive Action And Clinical Pharmacology: Although the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. Hydralazine, by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating…

APO®-TICLOPIDINE Apotex Ticlopidine HCl Inhibitor of Platelet Function Action And Clinical Pharmacology: Ticlopidine is an inhibitor of platelet aggregation. It causes a time and dose-dependent inhibition of platelet aggregation and release of platelet factors, as well as prolongation of bleeding time. The drug has no significant in vitro activity. The exact mechanism of action is not fully characterized, but does not involve inhibition of the prostacyclin/thromboxane pathways or platelet cAMP….

APO®-DOMPERIDONE Apotex Domperidone Maleate Modifier of Upper Gastrointestinal Motility Action And Clinical Pharmacology: Domperidone is a peripheral dopamine antagonist structurally related to the butyrophenones with antiemetic and gastroprokinetic properties. Domperidone effectively increases esophageal peristalsis and lower esophageal sphincter pressure (LESP), increases gastric motility and peristalsis, enhances gastroduodenal coordination and consequently facilitates gastric emptying and decreases small bowel transit time. The mechanism of action of domperidone is related to its peripheral…

APO®-ETODOLAC Apotex Etodolac Anti-inflammatory Action And Clinical Pharmacology: Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic properties in animal models. The pharmacological actions of etodolac are thought to be related to inhibition of prostaglandin biosynthesis at the site of inflammation. Etodolac is a racemic mixture of R- and S-etodolac. As with other NSAIDs, it has been demonstrated in animals that the S-form is biologically active…

APO®-KETOCONAZOLE Apotex Ketoconazole Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma membrane. The…

APO®-MOCLOBEMIDE Apotex Moclobemide Antidepressant Action And Clinical Pharmacology: Moclobemide is a short-acting, reversible inhibitor of monoamine oxidase type A (RIMA). It is a benzamide derivative which inhibits the deamination of serotonin, noradrenaline and dopamine. This action leads to increased concentrations of these neurotransmitters, which may account for the antidepressant activity of moclobemide. Monoamine oxidases are currently subclassified into 2 types, A and B, which differ in their substrate specificity. Moclobemide…

APO®-CROMOLYN Apotex Sodium Cromoglycate Seasonal Rhinitis Prophylaxis Action And Clinical Pharmacology: In the immediate allergic reaction (Type I) the union of antigen with reaginic antibody leads to the formation and release of spasmogens and other mediators of the anaphylactic reaction. Sodium cromoglycate appears to block a step in the chain of events triggered by this union. This property accounts for the prophylactic rather than symptomatic approach to the management of…

ANZEMET™ Hoechst Marion Roussel Dolasetron Mesylate Antiemetic Action And Clinical Pharmacology: Dolasetron and its active metabolite, hydrodolasetron (MDL 74156), are selective 5-HT3 receptor antagonists shown not to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is…