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NOVOCAIN® Sanofi Procaine HCl Local Anesthetic Action And Clinical Pharmacology: Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibres….

NOVAMOXIN® Novopharm Amoxicillin Trihydrate Antibiotic Action And Clinical Pharmacology: Amoxicillin exerts its bactericidal action by interfering with bacterial cell wall synthesis. Indications And Clinical Uses: The treatment of infections due to susceptible strains of the following microorganisms: Gram-negative organisms: H. influenzae, P. mirabilis and N. gonorrhea. Gram-positive organisms: streptococci (including S. faecalis and S. pneumoniae). Amoxicillin is not active against P. aeruginosa, indole-positive Proteus species, S. marcescens, Klebsiella and Enterobacter…

NOVAHISTEX® C Hoechst Marion Roussel Codeine Phosphate – Phenylephrine HCl Antitussive – Decongestant Indications And Clinical Uses: The treatment of adults with cough associated with inflamed mucosa, which does not respond to products of lesser potency. Dosage: Adults: 5 mL every 4 to 6 hours. Children: 6 to 12 years, one-half adult dosage; not recommended for children under 6 years. Availability And Storage: Each 5 mL of red, raspberry flavored…

NOVASOURCE™ RENAL Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A nutritionally complete, calorically dense, moderate protein formula with a vitamin/mineral profile designed for dialysis patients with acute and chronic renal failure. Appropriate for both oral and tube feeding use. Precautions: Not for parenteral administration. Dosage And Administration: 1 000 mL or 8 360 kJ (4.2 Tetra Brik Paks or 2 000 kcal) provides at least 100% of the Canadian…

NOVAHISTEX® DH EXPECTORANT Hoechst Marion Roussel Hydrocodone Bitartrate – Guaifenesin – Phenylephrine HCl Antitussive – Expectorant – Decongestant Indications And Clinical Uses: In adults, to facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contraindications, Precautions, Adverse Effects  Guaifenesin has been shown to produce a color interference with certain clinical laboratory determinations of 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic…

NOVAHISTEX® DH Hoechst Marion Roussel Hydrocodone Bitartrate – Phenylephrine HCl Antitussive – Decongestant Indications And Clinical Uses: The treatment of adults with cough associated with inflamed mucosa, which does not respond to products of lesser potency. Contra-Indications: Patients undergoing therapy with MAO inhibitors, hypersensitivity to any of the components. Precautions: Before prescribing medication to suppress or modify cough, it is important to ascertain that the underlying cause of the cough…

NORVASC™ Pfizer Amlodipine Besylate Antihypertensive – Antianginal Action And Clinical Pharmacology: Amlodipine is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). Amlodipine is a member of the dihydropyridine class of calcium antagonists. Mechanism of Action: The therapeutic effect of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into vascular smooth muscle and…

NORMACOL® Rivex Pharma Sterculia Bulk Laxative Indications And Clinical Uses: Sterculia is used as a bulk laxative, since by taking up moisture it increases the volume of the feces and promotes peristalsis. Ten mL of sterculia provide dietary bulk equivalent to 2 kg of fresh vegetables. It provides gentle relief of occasional constipation. Produces bowel movement in 12 to 72 hours. Precautions: As with all hygroscopic laxatives, it is important…

NOROXIN® Ophthalmic Solution MSD Norfloxacin Antibacterial Action And Clinical Pharmacology: Norfloxacin ophthalmic solution is a fluoroquinolone carboxylic acid antibacterial agent for ocular administration. Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level 3 specific actions have been attributed to norfloxacin in the inhibition of E. coli cells: inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, inhibition of the relaxation of supercoiled DNA and…

NOROXIN® MSD Norfloxacin Antibacterial Agent Action And Clinical Pharmacology: Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level 3 specific actions have been attributed to norfloxacin in the inhibition of E. coli cells: inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, inhibition of the relaxation of supercoiled DNA, promotion of double-stranded DNA breakage. Pharmacokinetics: Mean peak serum concentrations were 0.8 and 1.5 mg/L…