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OCUFLOX™ Allergan Ofloxacin Antibacterial Agent Action And Clinical Pharmacology: The primary mechanism of action of ofloxacin appears to be the specific inhibition of DNA gyrase (topoisomerase II). This enzyme is responsible for the negative supercoiling of bacterial DNA and consequently for its topological configuration, governing functions such as RNA transcription, protein synthesis, DNA replication and repair functions. Indications And Clinical Uses: For the treatment of conjunctivitis when caused by susceptible…

OMNI-TUSS® Rh´ne-Poulenc Rorer Codeine – Chlorpheniramine – Ephedrine – Phenyltoloxamine (Resin Complex) Antitussive – Decongestant – Expectorant Indications And Clinical Uses: To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contra-Indications: Hypertension, cardiac disease, hyper- thyroidism, prostatic hypertrophy, sensitivity to any of the components, patients receiving MAO inhibitors. Precautions: Before prescribing medication to suppress or modify cough,…

NYTOL™, NYTOL™ Extra Strength Block Drug Diphenhydramine HCl Sleep Aid Action And Clinical Pharmacology: The primary action of diphenhydramine is the antagonism of certain effects of histamine such as broncho-constriction and capillary dilation. The most frequently encountered secondary effects of diphenhydramine are related to CNS depression. The effects vary from slight drowsiness to deep sleep and have been reported to include the inability to concentrate, lassitude, dizziness, muscular weakness and…

OCCLUSAL™ Medicis Salicylic Acid Verrucae Therapy Action And Clinical Pharmacology: Although the exact mode of action of salicylic acid in the treatment of warts is not known, its activity appears to be associated with its keratolytic action which results in mechanical removal of epidermal cells infected with wart viruses. Indications And Clinical Uses: In the treatment and removal of common warts and plantar warts. Contra-Indications: Occlusal should not be used…

OCCLUSAL™-HP Medicis Salicylic Acid Verrucae Therapy Action And Clinical Pharmacology: Although the exact mode of action of salicylic acid in the treatment of warts is not known, it activity appears to be associated with its keratolytic action which results in mechanical removal of epidermal cells infected with wart viruses. Indications And Clinical Uses: In the treatment and removal of common warts and plantar warts. Contra-Indications: Occlusal-HP should not be used…

NUTRISOURCE® HN Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high nitrogen, complete fibre containing tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function. Recommended for both short-term and long-term tube feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 6 cans [1 500 mL or 7 520 kJ (1 800 kcal)] provides at least 100%…

NUTRISOURCE® Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A standard, fibre containing tube feeding (nasogastric, nasoduodenal or jejunal) for patients with normal gastrointestinal function. Recommended for both short-term and long-term tube feeding. Not recommended when a low residue tube feeding is required. Precautions: Not for parenteral administration. Dosage And Administration: 6 cans [1 500 mL or 7 520 kJ (1 800 kcal)] provides at least 100% of the Canadian…

NUPERCAINAL® Cream NUPERCAINAL® Ointment Novartis Consumer Health Dibucaine – Domiphen Bromide Topical Anesthetic Indications And Clinical Uses: For the relief of pain and itching in hemorrhoids, anal fissure, abrasions, minor burns, sunburn, chapping, herpes simplex, herpes zoster, insect bites, pruritus. The cream is also indicated for local antisepsis. Precautions: Not more than 2 tubes of the cream, or 1 tube of the ointment, should be applied within 24 hours to…

NUROMAX™ Glaxo Wellcome Doxacurium Chloride Nondepolarizing Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Doxacurium is a long-acting, nondepolarizing, skeletal neuromuscular blocking agent for i.v. administration. Nondepolarizing agents antagonize the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plates. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine. Pharmacodynamics: Doxacurium is approximately 2.5 to 3 times more potent than…

NOVO-VALPROIC Novopharm Valproic Acid Anticonvulsant Action And Clinical Pharmacology: Although not yet established, the mechanism of valproic acid’s anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA). The effect of the drug on the neuronal membrane is unknown. Valproic acid is rapidly absorbed after oral administration, with peak serum levels occurring approximately 1 to 4 hours after a single oral dose. The half-life of valproic acid…