You searched for : 'C'

NITRO-DUR® Key Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilation of both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure (preload). Arteriolar relaxation reduces systemic vascular resistance and…

NITROGLYCERIN General Monograph, CPhA Glyceryl Trinitrate Antianginal – Antihypertensive Pharmacology: Nitroglycerin, in common with other nitrates, produces generalized vasodilation, thereby decreasing venous return and workload on the heart. Both arterial and venous dilation occur, although venous effects predominate. Coronary vasodilation also occurs even in the presence of atherosclerosis. Relaxation of vascular smooth muscle is a result of stimulation of cyclic guanosine monophosphate (GMP) production as well as inhibition of thromboxane…

NITROLINGUAL® Spray Rhône-Poulenc Rorer Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal action of nitroglycerin is that of all nitrates, namely relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demand rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. Dilation…

NITROL® Rhône-Poulenc Rorer Nitroglycerin Antianginal – Vasodilator Action And Clinical Pharmacology: The principal action of nitroglycerin is that of all nitrates, namely relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demands rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds….

NIMBEX® Glaxo Wellcome Cisatracurium Besylate Nondepolarizing Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Cisatracurium is an intermediate-acting, nondepolarizing neuromuscular blocking agent for i.v. administration. Cisatracurium, 1 of 10 isomers of atracurium besylate, constitutes approximately 15% of that mixture. Cisatracurium binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in block of neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as…

NICORETTE® PLUS Hoechst Marion Roussel Nicotine Polacrilex Smoking Cessation Aid Action And Clinical Pharmacology: The active component of Nicorette Plus is nicotine in the form of a natural extract from the tobacco plant. In small doses, nicotine stimulates autonomic ganglia. Larger doses of the drug result in a blockage of the ganglia. The effects on autonomic ganglia vary according to the degree of tolerance to nicotine. The major cardiovascular effects…

NICORETTE® Hoechst Marion Roussel Nicotine Polacrilex Smoking Cessation Aid Action And Clinical Pharmacology: The active component of Nicorette is nicotine in the form of a natural extract from the tobacco plant. In small doses, nicotine stimulates autonomic ganglia. Larger doses of the drug result in a blockage of the ganglia. The effects on autonomic ganglia vary according to the degree of tolerance to nicotine. The major cardiovascular effects of nicotine…

NICOTROL® Johnson & Johnson• Merck Nicotine Stop Smoking Aid Action And Clinical Pharmacology: Nicotrol is a multilayered, laminated, flexible thin film containing nicotine as the active ingredient. Nicotrol has been specifically designed to provide a 16-hour rate controlled delivery of nicotine following its application to intact skin. It is intended to be applied during the day and removed at night prior to sleeping, thus minimizing the potential for any sleep…

NIACIN NIACINAMIDE General Monograph, Nicotinic Acid, Vitamin B3 Nicotinamide Vitamin Action And Clinical Pharmacology: Niacin and niacinamide are water-soluble B complex vitamins. In vivo, niacin is converted to niacinamide, a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are coenzymes involved in glycogenolysis, tissue respiration and lipid metabolism. Niacin deficiency results in pellagra, a chronic wasting disease characterized by dermatitis, dementia and diarrhea. Niacin produces…

NIACIN SUSTAINED RELEASE Stanley Nicotinic Acid Vitamin Action And Clinical Pharmacology: Nicotinic acid, when released, is readily absorbed from the gastrointestinal tract following oral administration and widely distributed in the body fluids and tissues, even in the breast milk. The main route of metabolism in the liver is conversion first to nicotinamide then to N-methyl nicotinamide, the 2-pyridone and 4-pyridone derivatives and nicotinuric acid formed which are excreted in the…