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Rabies Vaccine Inactivated (Diploid Cell Origin), Dried Connaught Vaccine Action And Clinical Pharmacology: The administration of Rabies Vaccine Inactivated (Diploid Cell Origin), Dried stimulates the rapid development of specific antibodies. Pre-exposure Immunization: Pre-exposure clinical trials have been carried out since 1979 with the present vaccine or its less purified predecessors in over 600 volunteers. Following 3 injections of 1 mL each of vaccine, all developed antibodies at a level of…

QUINTASA® Ferring 5-Aminosalicylic Acid Lower Gastrointestinal Anti-inflammatory Action And Clinical Pharmacology: 5-aminosalicylic acid (5-ASA) has been recognized as the therapeutically active moiety of sulfasalazine, a drug used to treat inflammatory bowel disease. 5-ASA has in vitro and in vivo pharmacologic effects that decrease leukotriene production, scavenge for free radicals and inhibit leukocyte chemotaxis. While its exact mode of action is currently unknown, any of these biochemical mechanisms may play a…

RAFTON® Liquid RAFTON® Tablets Ferring Alginic Acid Compound Gastroesophageal Reflux Therapy Action And Clinical Pharmacology: Rafton forms a protective neutralizing foam barrier in the stomach that effectively stops the upward flow of stomach acids into the esophagus providing fast relief of heartburn. Indications And Clinical Uses: For the effective relief of day or night-time heartburn or for discomfort of the esophagus due to upward flow of stomach acids. Precautions: Each…

QUIBRON®-T QUIBRON®-T/SR Bristol Theophylline Bronchodilator Action And Clinical Pharmacology: Theophylline is a xanthine derivative structurally related to theobromine and caffeine. It has 2 distinct actions in the airways of patients with reversible obstruction: smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., nonbronchodilator prophylactic effects). While its mechanisms of action are not known with certainty, studies in animals suggest that theophylline bronchodilation is…

QUESTRAN® QUESTRAN® LIGHT Bristol Cholestyramine Resin Antidiarrheal – Antihypercholesterolemic Action And Clinical Pharmacology: Cholestyramine is a quarternary ammonium anion exchange resin with a polystyrene polymer skeleton. As the chloride salt, it binds bile acids both in vitro and in vivo, exchanging chloride for bile acid. Cholesterol is probably the sole precursor of bile acids. During normal digestion, bile acids are secreted into the intestines. A major portion of the bile…

QUINATE Rougier Quinidine Gluconate Antiarrhythmic Agent Action And Clinical Pharmacology: Quinidine depresses excitability, conduction velocity and contractility of most cardiac tissues by a direct action on cardiac cells. Indirectly, cardiac tissues will also be affected by the anticholinergic and a-adrenoceptor blocking properties of quinidine. According to Vaughan Williams-Harrison antiarrhythmic drug classification, quinidine is a Class IA agent. Thus, quinidine reduces the maximal rate of phase 0 depolarization, prolongs repolarization and…

QUINIDINE SULFATE Glaxo Wellcome Antiarrhythmic Pharmacology: Quinidine depresses excitability, conduction velocity and contractility of most cardiac tissues by a direct action on cardiac cells. Indirectly, cardiac tissues will also be affected by the anticholinergic and a-adrenoceptor blocking properties of quinidine. According to Vaughan Williams’ antiarrhythmic drug classification, quinidine is a Class 1A agent. Thus, quinidine reduces the maximal rate of phase 0 depolarization, prolongs repolarization and refractory periods and, in…

QUINIDINE General Monograph, Quinidine Antiarrhythmic – Antimalarial Action And Clinical Pharmacology: Quinidine is a class IA antiarrhythmic agent according to the Vaughan-Williams classification. It depresses most cardiac tissues by a direct action on cardiac cells. Quinidine depresses the rapid inward depolarizing sodium current, thereby reducing the amplitude of the action potential without affecting the resting potential. The slope of the slow depolarization phase of Purkinje fibres is reduced, and the…

PROBETA® Allergan Levobunolol HCl – Dipivefrin HCl Glaucoma Therapy Action And Clinical Pharmacology: Probeta is a combination of levobunolol (a noncardioselective beta-adrenoceptor blocking agent) and dipivefrin (an adrenergic agonist) which acts to lower elevated intraocular pressure (IOP). Elevated IOP presents a major risk factor in glaucomatous field loss. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss. Poor ocular perfusion may…

PRINIVIL® MSD Lisinopril Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Lisinopril is an ACE inhibitor which is used in the treatment of hypertension, congestive heart failure and following myocardial infarction in hemodynamically stable patients. Angiotensin converting enzyme (ACE) is a peptidyl dipeptidase which catalyzes the conversion of angiotensin I to the pressor substance, angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II, which leads to increased plasma…