You searched for : 'X'

PRINZIDE® MSD Lisinopril – Hydrochlorothiazide Angiotensin Converting Enzyme Inhibitor – Diuretic Action And Clinical Pharmacology: Prinzide combines the action of an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide. Lisinopril: Angiotensin converting enzyme (ACE) is a peptidyl dipeptidase which catalyzes the conversion of angiotensin I to the pressor substance, angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II, which leads to increased plasma renin activity (due to…

PRO-BANTHINE® Roberts Propantheline Bromide Anticholinergic Action And Clinical Pharmacology: Propantheline bromide is a synthetic quaternary ammonium anticholinergic agent which inhibits gastrointestinal motility and spasm and diminishes gastric acid secretion. The drug also inhibits the action of acetylcholine at the postganglionic nerve endings of the parasympathetic nervous system. Its effects are similar to those of atropine although they last longer (6 hours). The antispasmodic effects on the gastrointestinal tract may occur…

PRIMACOR® Sanofi Milrinone Lactate Inotrope – Vasodilator Action And Clinical Pharmacology: Milrinone is a positive inotrope and vasodilator, with little chronotropic activity, different in structure and mode of action from either the digitalis glycosides or catecholamines. Milrinone, at relevant inotropic and vasorelaxant concentrations, is a selective inhibitor of peak III cAMP phosphodiesterase isozyme in cardiac and vascular muscle. This inhibitory action is consistent with cAMP mediated increases in intracellular ionized…

PRIMAQUINE Sanofi Primaquine Phosphate Antimalarial Action And Clinical Pharmacology: Primaquine is an 8-aminoquinoline compound which eliminates tissue (exo-erythrocytic) infection. Thereby, it prevents the development of the erythrocytic forms of the parasite which are responsible for relapses in vivax and ovale malaria. Primaquine phosphate is also active against gametocytes of P. falciparum. Indications And Clinical Uses: For the radical cure (prevention of relapse) of vivax and ovale malaria. Contra-Indications: In acutely…

PRIMENE® Clintec Amino Acids I.V. Nutritive Supplement Action And Clinical Pharmacology: Primene is a sterile, nonpyrogenic, hypertonic solution of essential and nonessential amino acids in a Pharmacy Bulk Package. A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use in a pharmacy admixture program and is restricted to the preparation of admixtures for i.v. infusion. Primene provides a mixture of essential and nonessential amino acids as…

PREVACID® Abbott Lansoprazole H KATPase Inhibitor Note: When used in combination with antimicrobials for the eradication of H. pylori, the product monograph for those agents should be consulted. Action And Clinical Pharmacology: Lansoprazole inhibits the gastric H KATPase (the proton pump) which catalyzes the exchange of Hand K It is effective in the inhibition of both basal acid secretion and stimulated acid secretion. In healthy subjects, single and multiple doses…

PREMARIN® TABLETS Wyeth-Ayerst Conjugated Estrogens Estrogenic Hormones Action And Clinical Pharmacology: Estrogen drug products act by regulating the transcription of a limited number of genes. They may act directly at the cell’s surface via non “estrogen receptor” mechanism or directly with the estrogen receptor inside the cell. Estrogens diffuse through cell membranes, distribute themselves throughout the cell, and bind to and activate the nuclear estrogen receptor, a DNA-binding protein which…

PRENAVITE® Roberts Iron – Calcium – Vitamins Prenatal Supplement With Folic Acid Indications And Clinical Uses: As a dietary supplement to meet increased needs in pregnancy and lactation. Contra-Indications: Hemosiderosis, hemochromatosis, hemolytic anemias. Precautions: Neurologic involvement may develop or progress, despite temporary remission of anemia, in patients with pernicious anemia who receive more than 100 g of folic acid per day and who are inadequately treated with vitamin B12. Periodic…

PREPARATION H® CLEANSING PADS PREPARATION H® COOLING GEL PREPARATION H® CREAM PREPARATION H® OINTMENT PREPARATION H® SUPPOSITORIES Whitehall-Robins Hamamelis Water – Glycerin Phenylephrine HCI – Hamamelis Water Live Yeast Derivative (Bio-Dyne) – Shark Liver Oil Live Yeast Derivative (Bio-Dyne) – Shark Liver Oil Live Yeast Derivative (Bio-Dyne) – Shark Liver Oil Hemorrhoid Therapy – Anal Hygiene Hemorrhoidal Treatment Indications And Clinical Uses: Cleansing Pads: hemorrhoidal, toilet tissue irritation, anal cleansing…

PREPIDIL® GEL Pharmacia & Upjohn Dinoprostone Prostaglandin Action And Clinical Pharmacology: Dinoprostone gel, which contains a prostaglandin E2 analogue as the active ingredient, causes cervical ripening preparatory to the onset of labor when it is administered endocervically. Although the local effects of prostaglandin E2 on cervical maturation is not specifically known, experimental data indicates the drug enhances cervical hemodynamics which in turn promotes ripening of the cervix. Indications And Clinical…