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RIFADIN® Hoechst Marion Roussel Rifampin Antituberculous Antibiotic Action And Clinical Pharmacology: Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase. This is the probable mechanism of action by which rifampin exerts its therapeutic effect. Pharmacokinetics: Absorption is more rapid when rifampin is administered 1 hour before meals. Peak blood levels in normal adults vary widely from individual to individual. Peak levels occur between…

RHINALAR® Roche Flunisolide Nasal Mist Allergic Rhinitis Therapy Action And Clinical Pharmacology: Flunisolide has demonstrated marked anti-inflammatory and antiallergic efficacy in classical animal test systems. It is a corticosteroid which is several hundred times more potent in animal anti-inflammatory assays than the cortisol standard. Clinical studies with flunisolide have shown a topical activity on the nasal mucous membrane with minimal associated systemic activity at the low spray doses administered. The…

RETIN-A® Janssen-Ortho Tretinoin Comedolytic Agent Action And Clinical Pharmacology: Studies in animals have shown that tretinoin supplies all the physiologic requirements of vitamin A except those needed for vision and reproduction. When animals were fed a diet in which vitamin A was replaced by vitamin A acid, there was no storage in the liver. This suggests that the acid may be the tissue-active form which is important for epithelial growth…

RESTORIL® Novartis Temazepam Hypnotic Action And Clinical Pharmacology: General: Temazepam is a benzodiazepine with hypnotic properties. Benzodiazepines act as depressants of the CNS. It is believed that benzodiazepines enhance or facilitate the effects of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Benzodiazepines act as agonists at the benzodiazepine receptor sites. The benzodiazepine-GABA receptor-chloride ionophore complex functions mainly in the gating of the chloride channel. Benzodiazepines are thought to produce their pharmacological…

RETISOL-A® Stiefel Tretinoin Acne Therapy Action And Clinical Pharmacology: The precise mechanism of action of tretinoin on the skin is not fully understood. It is known that tretinoin is both pharmacologically and structurally related to vitamin A which regulates epithelial cell growth and differentiation. Tretinoin itself is known to have an irritant and keratolytic effect on the skin. These 2 actions which occur simultaneously have been shown histologically in both…

Retrovir (AZT) Glaxo Wellcome Zidovudine Antiretroviral Agent Action And Clinical Pharmacology: Zidovudine is a potent inhibitor of the in vitro replication of some retroviruses including human immunodeficiency virus, HIV. Zidovudine is a thymidine analogue in which the 3-hydroxy (-OH) group is replaced by an azido(-N3) group. Cellular thymidine kinase converts zidovudine into zidovudine monophosphate. The monophosphate is further converted into the diphosphate by cellular thymidylate kinase and to the triphosphate…

RESOURCE® JUST FOR KIDS Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A standard lactose-, gluten- and fiber-free liquid formula designed to meet the nutritional needs of children 1 to 12 years of age with normal gastrointestinal function. Appropriate for both oral or tube feeding use. Precautions: Not for parenteral administration. Not for patients with galactosemia. Dosage And Administration: 1 200 mL or 5 020 kJ (5.1 aseptic Tetra Brik…

RESOURCE® PLUS Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A high-calorie liquid preparation providing complete, balanced nutrition. Energy density is 1 490 kJ (355 kcal)/Tetra Pak and provides a concentrated source of calories in a limited volume for patients with high protein requirements. When utilized to provide total nutrition, Resource Plus can deliver high energy intakes required by hypermetabolic patients who are nutritionally depleted, and are unable to tolerate…

RESOURCE® Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: A complete balanced low-residue liquid nutrition supplement for use in feeding situations where the patient’s diet requires support or where conditions preclude normal food intake. Precautions: Not for parenteral use. Shake Tetra Pak of liquid well before opening. Dosage And Administration: Oral: As a supplement with or between meals: 1 to 3 Tetra Paks daily, 1 050 to 3 150 kJ…

RESONIUM CALCIUM Sanofi Calcium Polystyrene Sulfonate Ion Exchange Resin Action And Clinical Pharmacology: Calcium polystyrene sulfonate is a cation exchange resin prepared in the calcium phase. Each gram of resin has a theoretical in vitro exchange capacity of about 1.3 to 2 mmol of potassium. In vivo, the actual amount of potassium bound will be less than this. The sodium content of the resin is less than 1 mg/g. The…