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NUMORPHAN® DuPont Pharma Oxymorphone HCl Analgesic Action And Clinical Pharmacology: Oxymorphone is a potent narcotic analgesic. When administered parenterally, 1 mg is approximately equivalent in analgesic activity to 10 mg of morphine sulfate. The onset of action of parenterally injected oxymorphone is rapid and the initial effects are usually perceived within 5 to 10 minutes, with analgesia persisting for approximately 3 to 6 hours. Oxymorphone is conjugated with glucuronic acid…

NUROMAX™ Glaxo Wellcome Doxacurium Chloride Nondepolarizing Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Doxacurium is a long-acting, nondepolarizing, skeletal neuromuscular blocking agent for i.v. administration. Nondepolarizing agents antagonize the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plates. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine. Pharmacodynamics: Doxacurium is approximately 2.5 to 3 times more potent than…

NOVAMOXIN® Novopharm Amoxicillin Trihydrate Antibiotic Action And Clinical Pharmacology: Amoxicillin exerts its bactericidal action by interfering with bacterial cell wall synthesis. Indications And Clinical Uses: The treatment of infections due to susceptible strains of the following microorganisms: Gram-negative organisms: H. influenzae, P. mirabilis and N. gonorrhea. Gram-positive organisms: streptococci (including S. faecalis and S. pneumoniae). Amoxicillin is not active against P. aeruginosa, indole-positive Proteus species, S. marcescens, Klebsiella and Enterobacter…

NOVAHISTEX® C Hoechst Marion Roussel Codeine Phosphate – Phenylephrine HCl Antitussive – Decongestant Indications And Clinical Uses: The treatment of adults with cough associated with inflamed mucosa, which does not respond to products of lesser potency. Dosage: Adults: 5 mL every 4 to 6 hours. Children: 6 to 12 years, one-half adult dosage; not recommended for children under 6 years. Availability And Storage: Each 5 mL of red, raspberry flavored…

NOVANTRONE® Wyeth-Ayerst Mitoxantrone HCl Antineoplastic Action And Clinical Pharmacology: Although its mechanism of action has not been determined, mitoxantrone is a DNA-reactive agent. It induces nuclear aberrations with chromosome scattering in cell cultures (human colon carcinoma line) and is a potent inhibitor of RNA and DNA synthesis. Compared on an equimolar basis, mitoxantrone is 7 times more potent than doxorubicin in inhibiting the uptake of -uridine and 4 times more…

NOVAHISTEX® DM NOVAHISTEX® DM Decongestant NOVAHISTEX® DM Decongestant Expectorant NOVAHISTINE® DM NOVAHISTINE® DM Decongestant NOVAHISTINE® DM Decongestant Expectorant Hoechst Marion Roussel Dextromethorphan HBr Dextromethorphan HBr – Pseudoephedrine HCl Dextromethorphan HBr – Pseudoephedrine HCl – Guaifenesin Dextromethorphan HBr Dextromethorphan HBr – Pseudoephedrine HCl Dextromethorphan HBr – Pseudoephedrine HCl – Guaifenesin Antitussive Antitussive – Decongestant Antitussive – Decongestant – Expectorant Antitussive Antitussive – Decongestant Antitussive – Decongestant – Expectorant Action And Clinical…

NOVAHISTEX® DH EXPECTORANT Hoechst Marion Roussel Hydrocodone Bitartrate – Guaifenesin – Phenylephrine HCl Antitussive – Expectorant – Decongestant Indications And Clinical Uses: In adults, to facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contraindications, Precautions, Adverse Effects  Guaifenesin has been shown to produce a color interference with certain clinical laboratory determinations of 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic…

NOVAHISTEX® DH Hoechst Marion Roussel Hydrocodone Bitartrate – Phenylephrine HCl Antitussive – Decongestant Indications And Clinical Uses: The treatment of adults with cough associated with inflamed mucosa, which does not respond to products of lesser potency. Contra-Indications: Patients undergoing therapy with MAO inhibitors, hypersensitivity to any of the components. Precautions: Before prescribing medication to suppress or modify cough, it is important to ascertain that the underlying cause of the cough…

NOROXIN® Ophthalmic Solution MSD Norfloxacin Antibacterial Action And Clinical Pharmacology: Norfloxacin ophthalmic solution is a fluoroquinolone carboxylic acid antibacterial agent for ocular administration. Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level 3 specific actions have been attributed to norfloxacin in the inhibition of E. coli cells: inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, inhibition of the relaxation of supercoiled DNA and…

NOROXIN® MSD Norfloxacin Antibacterial Agent Action And Clinical Pharmacology: Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level 3 specific actions have been attributed to norfloxacin in the inhibition of E. coli cells: inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, inhibition of the relaxation of supercoiled DNA, promotion of double-stranded DNA breakage. Pharmacokinetics: Mean peak serum concentrations were 0.8 and 1.5 mg/L…