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NARCAN® DuPont Pharma Naloxone HCl Narcotic Antagonist Action And Clinical Pharmacology: Naloxone prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Naloxone is an essentially pure narcotic antagonist which does not possess the ‘agonistic’ or morphine-like properties characteristic of other narcotic antagonists. It does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotic or agonistic effects of other narcotic antagonists, it…

NAPROSYN® Roche Naproxen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Naproxen has demonstrated anti-inflammatory, analgesic and antipyretic properties in classical animal test systems. In patients with rheumatoid arthritis, the anti-inflammatory action has been shown by a reduction in joint swelling, pain, and duration of morning stiffness, and by enhanced grip strength and increased mobility. It exhibits an anti-inflammatory effect even in adrenalectomized animals, and therefore its action is not mediated…

MUMPSVAX® MSD Mumps Virus Vaccine, Live, Attenuated Mumps Prophylaxis Description: This vaccine is prepared from the Jeryl Lynn (B Level) strain, named after the patient from whom the virus was initially recovered. Mumpsvax is a sterile lyophilized preparation of the Jeryl Lynn (B level) strain of mumps virus. The virus was adapted to and propagated in cell cultures of chick embryo, free of avian leukosis, virus and other adventitious agents…

MUCAINE® Axcan Pharma Oxethazaine – Aluminum Hydroxide – Magnesium Hydroxide Antacid – Mucosal Anesthetic Action And Clinical Pharmacology: Alumina gel and magnesium hydroxide react chemically to neutralize or buffer existing quantities of stomach acid but have no direct effect on its production. This action increases gastric pH, providing symptomatic relief of hyperacidity. Gastroscopic observations reveal that alumina gel, especially when swallowed undiluted, forms a diffuse coating over the inflamed gastric…

MOBIFLEX® Roche Tenoxicam Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Tenoxicam is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. Its mechanism of action, as with other nonsteroidal anti-inflammatory agents, is not yet completely known. Tenoxicam is an inhibitor of prostaglandin biosynthesis both in vitro and in vivo (protects mice against arachidonic acid induced toxicity). In vitro tests of leukocyte peroxidase also suggest that tenoxicam may act as a…

MIRAPEX® Boehringer Ingelheim Pramipexole Dihydrochloride Antiparkinsonian Agent – Dopamine Agonist Action And Clinical Pharmacology: Pramipexole is a non ergot dopamine agonist with high in vitro specificity at the D2 subfamily of dopamine receptors. Pramipexole is a full agonist and exhibits higher affinity to the D3 receptor subtypes (which are in prominent distribution within the mesolimbic area) than to D2 or D4 receptor subtypes. While pramipexole exhibits high affinity for the…

MICROLAX® Pharmacia & Upjohn Micro-Enema Indications And Clinical Uses: Rectal constipation; or, as directed by a physician, to facilitate rectoscopic or sigmoidoscopic examination. Adverse Reactions: No severe reactions have been reported. Very occasionally slight cramps or tenesmus may occur. Dosage: Adults and children: the contents of 1 tube (5 mL) administered rectally but a second tube may be needed in severe cases; children under 3 years, insert only half the…

MICRO-K EXTENCAPS® MICRO-K-10 EXTENCAPS® Wyeth-Ayerst Microencapsulated Potassium Chloride Potassium Supplement Action And Clinical Pharmacology: Potassium ions participate in a number of physiological processes including the maintenance of intracellular tonicity; the transmission of nerve impulses; the contraction of cardiac, skeletal and smooth muscle; and the maintenance of normal renal function. Depletion may occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate…

MEXITIL® Boehringer Ingelheim Mexiletine HCl Antiarrhythmic Action And Clinical Pharmacology: Mexiletine is a class 1B antiarrhythmic agent based on the classification system of Vaughan-Williams with local anesthetic properties, similar in structure and activity to lidocaine. Mexiletine blocks the fast sodium channel in cardiac tissues, especially the Purkinje network, without involvement of the autonomic system. Mexiletine reduces the rate of rise and amplitude of the action potential and decreases automaticity (increases…

METHOTREXATE TABLETS USP Faulding Antimetabolite Action And Clinical Pharmacology: Methotrexate is an antimetabolite which competitively inhibits the enzyme folic acid reductase. During DNA synthesis and cellular reproduction, folic acid is reduced to tetrahydrofolic acid by the enzyme folic acid reductase. By interfering with the reduction of folic acid, methotrexate interferes with tissue cell reproduction. Generally, the most sensitive cells to the antimetabolite effect of methotrexate are those cells which are…