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PACLITAXEL INJECTION Boehringer Ingelheim Antineoplastic Caution: Paclitaxel is a toxic product and should be administered only by or under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel injection should be pre-treated using corticosteroids, antihistamines, and H2 antagonists (for example dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). All clinical studies referred to in this product monograph were conducted…

PROVERA® Pharmacia & Upjohn Medroxyprogesterone Acetate Progestin Action And Clinical Pharmacology: Medroxyprogesterone, an orally active progestational steroid (progestin) derived from a natural source (soy beans), when administered to women with adequate levels of estrogen (endogenous or exogenous), transforms a proliferative endometrium into a secretory endometrium. Furthermore, the anticancer activity of medroxyprogesterone at pharmacologic doses, may be dependent on its effect on the hypothalamic/pituitary/gonadal axis, estrogen receptors and metabolism of steroids…

PROZAC® Lilly Fluoxetine HCl Antidepressant – Antiobsessional – Antibulimic Action And Clinical Pharmacology: The antidepressant, antiobsessional, and antibulimic actions of fluoxetine are presumed to be linked to its ability to selectively inhibit the neuronal reuptake of serotonin. At clinically relevant doses fluoxetine blocks the uptake of serotonin into human platelets. Antagonism of muscarinic, histaminergic and a1-adrenergic receptors has been hypothesized to be associated with various anticholinergic, sedative and cardiovascular effects…

Bionutrix Prostanutrix Prostanutrix is a premium designer organic herbal supplement uniquely formulated by Bionutrix physicians to improve and optimize prostate health. This trademark formulation contains a specially balanced organic blend of saw palmetto and pygeum, the only two herbs that have been medically proven to safely and effectively treat and prevent prostate disorders and strengthen libido. Bionutrix is the only company to offer this potent prostate-specific formula in a reliably…

PROGLYCEM® Schering Diazoxide Hyperglycemic Agent Action And Clinical Pharmacology: Diazoxide, a benzothiadiazine derivative, when administered orally produces a prompt dose-related increase in blood glucose level, due primarily to an inhibition of insulin release from the pancreas and also to an extrapancreatic effect. The hyperglycemic effect begins within an hour and generally lasts no more than 8 hours in the presence of normal renal function. Diazoxide decreases the excretion of sodium…

PROCTOFOAM™-HC R & C Hydrocortisone Acetate – Pramoxine HCl Anorectal Therapy Action And Clinical Pharmacology: Proctofoam-HC combines the anti-inflammatory action of hydrocortisone with the surface anesthetic effect of pramoxine HCl. tag_IndicationsIndications Indications And Clinical Uses: The temporary relief of anorectal inflammation, pruritus, pain and swelling associated with hemorrhoids, proctitis, cryptitis, fissures, postoperative pain and pruritus ani. Contra-Indications: The presence of active infection, abscess, extensive fistulas or sinus tracts, tuberculosis, varicella,…

PROCYTOX® Carter Horner Cyclophosphamide Antineoplastic Action And Clinical Pharmacology: Although it is classified generally as an alkylating agent, cyclophosphamide itself is not an alkylating agent. It appears to be inactive in vitro when tested on cultures of human leukocytes or carcinomatous cells of human origin. It appears active metabolites of the drug exhibit the alkylating action. carc Cyclophosphamide’s metabolism is initiated by the mixed function oxidase enzymes of the liver…

OXSORALEN™ ICN Methoxsalen Melanin Repigmentation – Photochemotherapy of Atopic Dermatitis and Psoriasis Indications And Clinical Uses: Repigmentation of vitiliginous lesions, to protect against solar sensitivity. Oral route is preferred if extensive repigmentation is desired, since topical application can only be applied to a small area at a time. For treatment of psoriasis and atopic dermatitis in combination with high intensity UVA light. Contra-Indications: Hepatic insufficiency. Diseases associated with photosensitivity, such…

OXYCONTIN® Purdue Frederick Oxycodone HCl Opioid Analgesic Action And Clinical Pharmacology: Oxycodone is a semisynthetic opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, oxycodone produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of…

OXYTOCIN INJECTION, USP Abbott Oxytocic Action And Clinical Pharmacology: Oxytocin synthetic, acts on the smooth muscle of the uterus to stimulate contractions; response depends on the uterine threshold of excitability. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions and raises the…