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LOFENALAC® Mead Johnson Phenylketonuria Therapy Indications And Clinical Uses: For use as basic food in low phenylalanine dietary management of infants and children with phenylketonuria. Contra-Indications: Should not be used except for children with phenylketonuria. Precautions: Phenylalanine intake must be carefully controlled to prevent excessive blood levels and urinary excretion, and still provide enough for growth. Phenylalanine blood levels should be determined regularly. Physical and mental development should be carefully…

LOESTRIN™ 1.5/30 Parke-Davis Norethindrone Acetate – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Loestrin 1.5/30 achieves its contraceptive effect primarily by inhibition of ovulation through gonadotrophin suppression. It is well-established that oral contraceptives containing estrogen and progestogen affect hypothalamic, pituitary and ovarian functions. They may alter many other physiological systems. Although the exact mechanisms of action are incompletely understood, there is universal agreement that the inhibition of the ovulatory…

LOCACORTEN® VIOFORM® Eardrops Novartis Flumethasone Pivalate – Clioquinol Topical Aural Corticosteroid – Antibacterial – Antifungal Action And Clinical Pharmacology: Flumethasone pivalate is a moderately potent difluorinated glucocorticoid with anti-inflammatory, antipruritic, and vasoconstrictive properties. As it is a pivalate, its action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching. Clioquinol, the antimicrobial component of Locacorten Vioform…

LOCASALEN® Novartis Flumethasone Pivalate – Salicylic Acid Topical Corticosteroid – Squamolytic Action And Clinical Pharmacology: Locasalen exhibits pronounced anti-inflammatory, anti-allergic antiproliferative and antipruritic effects. Flumethasone pivalate, a topical corticoid of proven efficacy, is in solution in the ointment base rather than as suspended microcrystals and attains a higher degree of penetration into the skin where it remains active in the epidermis for a long period of time. The salicylic acid…

LITHANE™ Pfizer Lithium Carbonate Antimanic Agent Action And Clinical Pharmacology: Although lithium is useful for its antimanic effect and in preventing relapses in patients with a clearcut diagnosis of bipolar affective disorder, it has very little, if any, direct effect on moods, normal or abnormal. Lithium alters sodium transport in nerve and muscle cells, effects a shift toward intraneuronal metabolism of catecholamines and has an inhibitory action on the intracellular…

LIVOSTIN® NASAL SPRAY Janssen-Ortho Levocabastine HCl Histamine H1-antagonist Action And Clinical Pharmacology: Levocabastine is a potent, fast-acting and highly selective histamine H1-antagonist with a sustained duration of action. Within 10 minutes of topical application to the nose, levocabastine inhibits sneezing, itchy nose and rhinorrhea induced by nasal provocation with allergens. Orally-administered levocabastine provides a dose dependent inhibition of skin reactions to intradermal histamine. After repeated topical application to the nose,…

LIVOSTIN™ EYE DROPS CIBA Vision Levocabastine HCl Histamine H1-antagonist Action And Clinical Pharmacology: Levocabastine is a potent, fast-acting and highly selective histamine H1-antagonist with a sustained duration of action. Within 10 to 15 minutes of topical application to the eyes, levocabastine inhibits: itching, redness and chemosis induced by conjunctival provocation with histamine; itching, redness, chemosis, eyelid swelling, and tearing induced by conjunctival provocation with allergens; and itching and redness induced…

LIPACTIN® Novartis Consumer Health Heparin Sodium – Zinc Sulfate Symptomatic Treatment of Herpes Simplex I Action And Clinical Pharmacology: Lipactin is composed of heparin and zinc for topical application. Topical application of heparin produces accumulation of the heparin molecules in the corium of the skin while insignificant amounts are absorbed through the skin. Oral administration of heparin is associated with negligible anticoagulant effect as heparin is immediately metabolized in the…

LIPIDIL MICRO® Fournier Fenofibrate (Micronized) Lipid Metabolism Regulator Action And Clinical Pharmacology: Fenofibrate lowers elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fenofibrate increases the high density lipoprotein (HDL) cholesterol fraction. Fenofibrate appears to have a greater depressant effect on the very low density lipoproteins (VLDL) than on the low density…

LIPISORB® Mead Johnson Therapeutic Nutrient Indications And Clinical Uses: A nutritionally complete liquid diet specifically designed for patients with fat malabsorption (e.g., inflammatory bowel disease, cystic fibrosis, short bowel syndrome and HIV infection). It provides complete vitamins and minerals with a readily absorbed fat blend. This vanilla flavored beverage can be fed orally or as a tube feeding. tag_DosageDosage Dosage And Administration: As prescribed by a physician. Tube feeding may…