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LYSODREN Bristol Mitotane Antineoplastic Action And Clinical Pharmacology: Mitotane is an adrenal cytotoxic agent, and can cause adrenal inhibition, apparently without cellular destruction. Its biochemical mechanism of action is unknown. Available data suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex. In man, mitotane administration alters cortisol’s extra-adrenal metabolism, leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma corticosteroid…

LOZIDE® Servier Indapamide Hemihydrate Diuretic – Antihypertensive Agent Action And Clinical Pharmacology: Indapamide is a diuretic antihypertensive agent. The mechanism whereby indapamide exerts its action in the control of hypertension is not completely elucidated: both renal and extrarenal actions may be involved. The renal site of action is the proximal part of the distal tubule and the ascending part of Henle’s loop. Sodium and chloride ions are excreted in approximately…

LUDIOMIL® Novartis Pharmaceuticals Maprotiline HCl Antidepressant Action And Clinical Pharmacology: Maprotiline has been shown to exhibit an antidepressant action. Maprotiline strongly inhibits the uptake of norepinephrine in the brain and peripheral tissues, but has a notable lack of serotonergic uptake inhibition. It has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. Maprotiline has a strong antihistaminic activity and a weaker anticholinergic activity. Maprotiline also exerts a sedative effect on the…

LUPRON DEPOT® 3.75 mg/7.5 mg Abbott/TAP Pharmaceuticals Leuprolide Acetate Leuprolide Acetate for Depot Suspension Gonadotropin-releasing Hormone Analog for Management of Central Precocious Puberty in Children Action And Clinical Pharmacology: Leuprolide is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LHRH). The analog possesses greater potency than the natural hormone. When administered as indicated, leuprolide acts as a potent inhibitor of gonadotropin production. It is chemically unrelated…

LUPRON® DEPOT® 3.75 mg Abbott Leuprolide Acetate for Depot Suspension Gonadotropin-releasing Hormone Analog Action And Clinical Pharmacology: Leuprolide is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH or LHRH). The analog possesses greater potency than the natural hormone. When administered as indicated, leuprolide acts as a potent inhibitor of gonadotropin production. It is chemically unrelated to steroids. Unlike steroid hormones, leuprolide exerts specific action on the pituitary gonadotrophs…

LOTENSIN® Novartis Benazepril HCl Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Benazepril is an angiotensin converting enzyme (ACE) inhibitor which is used in the treatment of hypertension. Benazepril, after hydrolytic bioactivation to benazeprilat, inhibits angiotensin converting enzyme (ACE), a peptidyl dipeptidase catalyzing the conversion of angiotensin I to the vasoconstrictor angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex, leading to sodium resorption and potassium secretion…

LOTRIDERM® Schering Clotrimazole – Betamethasone Dipropionate Topical Antifungal – Corticosteroid Action And Clinical Pharmacology: Betamethasone dipropionate with clotrimazole combines the anti-inflammatory, antipruritic and vasoconstrictive activity of betamethasone dipropionate with the antifungal activity of clotrimazole. The primary action of clotrimazole is against dividing and growing organisms, possibly through reaction with the cell membrane. Indications And Clinical Uses: For the topical treatment of the following fungal dermal infections complicated by inflammatory pruritus:…

LOPRESOR® Novartis Pharmaceuticals Metoprolol Tartrate Beta-Adrenergic Receptor Blocking Agent Action And Clinical Pharmacology: Metoprolol is a b-adrenergic receptor-blocking agent. In vitro and in vivo animal studies have shown that it has a preferential effect on the b1-adrenoreceptors, chiefly located in cardiac muscle. This preferential effect is not absolute, however, and at higher doses, metoprolol also inhibits b2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. Metoprolol has no membrane-stabilizing or…

LOPID® Parke-Davis Gemfibrozil Antihyperlipidemic Agent Action And Clinical Pharmacology: Gemfibrozil is a lipid regulating agent which decreases serum triglycerides and total cholesterol, and increases high density lipoprotein cholesterol. The lipid-lowering changes occur primarily in the very low density lipoprotein (VLDL) fraction (Sf 20 to 400) rich in triglycerides and to a lesser extent in the low density lipoprotein (LDL) fraction (Sf0 to 20) rich in cholesterol. Gemfibrozil treatment of patients…

LOSEC® Astra Omeprazole Magnesium H KATPase Inhibitor Note: When used in combination with amoxicillin, clarithromycin or metronidazole, the product monographs for those agents must be consulted and followed. Action And Clinical Pharmacology: Omeprazole inhibits the gastric enzyme H KATPase (the proton pump) which catalyzes the exchange of Hand K It is effective in the inhibition of both basal acid secretion and stimulated acid secretion. The inhibition is dose dependent. Daily…