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LEUSTATIN® Janssen-Ortho Cladribine Antineoplastic – Chemotherapeutic Agent Warning: Cladribine should be administered under the supervision of a qualified physician experienced in the use of antineoplastic therapy. Suppression of bone marrow function should be anticipated. This is usually reversible and appears to be dose-dependent. Significant and prolonged lymphopenia has been noted. Serious neurological toxicity (including irreversible paraparesis and quadriparesis) has been reported in patients who received cladribine injection by continuous infusion…

LECTOPAM® Roche Bromazepam Anxiolytic – Sedative Action And Clinical Pharmacology: Bromazepam is a benzodiazepine with anxiolytic and sedative properties which are of value in the symptomatic relief of pathological anxiety in psychoneurotic patients. The absolute bioavailability of unchanged, orally administered bromazepam is 60%, and peak blood levels are achieved within 2 hours after administration. On average, 70% of bromazepam is bound to plasma proteins. Bromazepam is metabolized in the liver,…

LEDERLE LEUCOVORIN® CALCIUM Wyeth-Ayerst Citrovorum Factor Folic Acid Derivative Action And Clinical Pharmacology: Lederle Leucovorin Calcium (calcium folinate), the calcium salt of folinic acid (citrovorum factor), is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid. The biologically active compound of the mixture is the (-)-L-isomer. It is a metabolite of folic acid and an essential coenzyme for nucleic acid synthesis. Leucovorin is a reduced form of…

exoLERITINE® Injection LERITINE® Tablets Frosst Anileridine Phosphate Anileridine HCl Opioid Analgesic Action And Clinical Pharmacology: Anileridine, a synthetic opioid, is a strong analgesic. The chief pharmacologic action is exerted on the CNS. The analgesic effects usually are prompt in onset either orally or parenterally (approximately within 15 minutes). Duration of action is about 2 or 3 hours. Respiratory depression, when it occurs, is of shorter duration than that seen with…

LESCOL® Novartis Pharmaceuticals Fluvastatin Sodium Lipid Metabolism Regulator Action And Clinical Pharmacology: Fluvastatin is a fully synthetic HMG-CoA reductase inhibitor and is hydrophilic. Fluvastatin is a racemate of two erythro enantiomers of which one exerts the pharmacological activity. Fluvastatin is a competitive inhibitor of HMG-CoA reductase, which is responsible for the conversion of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) to mevalonate, a precursor of sterols, including cholesterol. The inhibition of cholesterol biosynthesis reduces…

LANVIS® Glaxo Wellcome Thioguanine Antileukemic Agent Action And Clinical Pharmacology: Thioguanine is a close relative of mercaptopurine and like the latter is an antimetabolite which blocks purine metabolism. It causes depletion of human bone marrow producing neutropenia, reticulopenia, anemia, thrombocytopenia, and prolongation of clotting time. The protracted but reversible aplasia of bone marrow closely resembles the effects of ionizing radiations. In man, thioguanine is extensively converted to 2-amino-6-methyl-mercaptopurine which is…

LARIAM® Roche Mefloquine HCl Antimalarial Agent Action And Clinical Pharmacology: Mefloquine acts on the asexual intraerythrocytic forms of the human malaria parasites: P. falciparum, P. vivax, P. malariae and P. ovale. Mefloquine is also effective against malaria parasites resistant to other antimalarials such as chloroquine, proguanil, pyrimethamine and pyrimethamine-sulfonamide combinations. Resistance to P. falciparum to mefloquine has been reported, mainly in parts of South-East Asia. Cross-resistance between mefloquine and halofantrine…

LAMISIL® Novartis Pharmaceuticals Terbinafine HCl Antifungal Action And Clinical Pharmacology: Terbinafine is an allylamine which has a broad spectrum of antifungal activity. At low concentrations terbinafine is fungicidal against dermatophytes, molds and certain dimorphic fungi. The activity against yeasts is fungicidal or fungistatic, depending on the species. Terbinafine interferes specifically with fungal sterol biosynthesis by inhibition of squalene epoxidase in the fungal cell membrane. This leads to a deficiency in…

LACRISERT® MSD Hydroxypropyl Cellulose Ophthalmic Insert Indications And Clinical Uses: In patients with moderate to severe dry eye syndromes, including keratoconjunctivitis sicca, especially in patients who remain symptomatic after an adequate trial of therapy with artificial tear solutions. Exposure keratitis. Decreased corneal sensitivity. Contra-Indications: Hypersensitivity to hydroxypropyl cellulose. Precautions: Instructions for inserting and removing Lacrisert should be carefully followed. Occupational Hazards: Because this product may produce transient blurring of vision,…

LACTAID® McNeil Consumer Products Lactase Enzyme Lactose Digestant Action And Clinical Pharmacology: Converts the disaccharide lactose via hydrolysis into its monosaccharide components, glucose and galactose. Tablets: In vivo activity has been demonstrated with drug administration at time of milk consumption and at time of consumption of other lactose containing solid and liquid foods. Drops: Fifteen drops will hydrolyze nearly all of the lactose in 1 L of milk at refrigerator…