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NORVASC™ Pfizer Amlodipine Besylate Antihypertensive – Antianginal Action And Clinical Pharmacology: Amlodipine is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). Amlodipine is a member of the dihydropyridine class of calcium antagonists. Mechanism of Action: The therapeutic effect of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into vascular smooth muscle and…

NORPRAMIN® Hoechst Marion Roussel Desipramine HCl Antidepressant Action And Clinical Pharmacology: Desipramine displays an antidepressant property similar to that of other tricyclic antidepressants. It is the active “in vivo” metabolite of imipramine and as such, shares many of imipramine’s pharmacologic effects. The anticholinergic actions of desipramine are responsible for many of the commonly observed side effects of the drug. Desipramine causes ECG changes such as prolongation of the P-R interval…

NOROXIN® MSD Norfloxacin Antibacterial Agent Action And Clinical Pharmacology: Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level 3 specific actions have been attributed to norfloxacin in the inhibition of E. coli cells: inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, inhibition of the relaxation of supercoiled DNA, promotion of double-stranded DNA breakage. Pharmacokinetics: Mean peak serum concentrations were 0.8 and 1.5 mg/L…

NORPLANT® Wyeth-Ayerst Levonorgestrel Contraceptive Implant Action And Clinical Pharmacology: Norplant consists of levonorgestrel implants, a set of 6 flexible closed capsules made of Silastic (dimethylsiloxane/methylvinylsiloxane copolymer) each containing 36 mg of the progestin levonorgestrel. Levonorgestrel, 18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(17a)-(-)-, is a totally synthetic and biologically-active progestin which exhibits no significant estrogenic activity and is highly progestational. The absolute configuration conforms to that of D-natural steroids. Levonorgestrel is not subjected to a “first-pass” effect…

NORGESIC™ NORGESIC™ FORTE 3M Pharmaceuticals Orphenadrine Citrate – ASA – Caffeine Analgesic – Skeletal Muscle Relaxant Indications And Clinical Uses: Symptomatic relief of mild to moderate pain. Contraindications, Precautions and Adverse Effects: See Norflex and ASA. Do not exceed the recommended dose without consulting a physician. Reye’s Syndrome may develop in individuals who have chickenpox, influenza, or flu symptoms. Some studies suggest a possible association between the development of Reye’s…

NORINYL® 1/50 Searle Norethindrone – Mestranol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis or thromboembolic…

NORITATE® Dermik Laboratories Canada Metronidazole Antirosacea Agent Action And Clinical Pharmacology: Metronidazole topical cream is particularly effective against the inflammatory papulopustular component of rosacea. The mechanisms by which metronidazole act in reducing inflammatory lesions of rosacea are unknown, but may include an antibacterial and/or an anti-inflammatory effect. Indications And Clinical Uses: For topical application in the treatment of inflammatory papules, pustules and erythema of rosacea. Contra-Indications: In individuals with a…

NORFLEX™ 3M Pharmaceuticals Orphenadrine Citrate Skeletal Muscle Relaxant Action And Clinical Pharmacology: The mode of therapeutic action has not been clearly identified but may be related to its analgesic properties. Orphenadrine citrate also possesses anticholinergic actions. Norflex is an extended release formulation that gives a peak level of 60 ng/mL at 8 hours following a 100 mg dose, as opposed to an immediate release product that gives a peak of…

NIX® Dermal Cream Glaxo Wellcome Permethrin Topical Scabicide Action And Clinical Pharmacology: Permethrin is a synthetic pyrethroid, which is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance. Lag…

NIX® Creme Rinse Warner-Lambert Consumer Healthcare Permethrin Topical Pediculicide – Ovicide Action And Clinical Pharmacology: Permethrin is a synthetic pyrethroid, active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance….