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NIZORAL® Shampoo McNeil Consumer Products Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and…

NIZORAL® Tablets Janssen-Ortho Ketoconazole Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma membrane….

NIZORAL® Cream Janssen-Ortho Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma…

NOLVADEX® NOLVADEX®-D Zeneca Tamoxifen Citrate Antineoplastic Action And Clinical Pharmacology: Tamoxifen, the active ingredient, is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to its ability to compete with estrogen for binding sites in target tissues such as breast and uterus. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA), and causes the regression of already established…

NITRONG® SR Rhône-Poulenc Rorer Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal action of Nitrong (nitroglycerin) is that of all nitrates, namely relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demands rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds….

NITROSTAT™ Parke-Davis Nitroglycerin Coronary Vasodilator Indications And Clinical Uses: For the prophylaxis, treatment and management of patients with angina pectoris. Contra-Indications: In patients with early myocardial infarction, severe anemia, increased intracranial pressure and those with a known hypersensitivity to nitroglycerin. Manufacturers’ Warnings In Clinical States: The use of nitroglycerin during the early course of acute myocardial infarction requires particular attention to hemodynamic monitoring and clinical status because of the possibility…

NITROGLYCERIN General Monograph, CPhA Glyceryl Trinitrate Antianginal – Antihypertensive Pharmacology: Nitroglycerin, in common with other nitrates, produces generalized vasodilation, thereby decreasing venous return and workload on the heart. Both arterial and venous dilation occur, although venous effects predominate. Coronary vasodilation also occurs even in the presence of atherosclerosis. Relaxation of vascular smooth muscle is a result of stimulation of cyclic guanosine monophosphate (GMP) production as well as inhibition of thromboxane…

NITROL® Rhône-Poulenc Rorer Nitroglycerin Antianginal – Vasodilator Action And Clinical Pharmacology: The principal action of nitroglycerin is that of all nitrates, namely relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demands rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds….

NIMOTOP® NIMOTOP® I.V. Bayer Nimodipine Adjunct in the Management of Subarachnoid Hemorrhage – Calcium Channel Blocking Agent Action And Clinical Pharmacology: Delayed neurologic deterioration secondary to cerebral ischemic deficits is believed to be a major determinant of outcome in patients who survive their initial subarachnoid hemorrhage (SAH). Nimodipine is a calcium channel blocker of the dihydropyridine group. It appears to have a more marked effect on the cerebral circulation than…

NITOMAN® Roche Tetrabenazine Monoamine Depleting Agent Action And Clinical Pharmacology: The central effects of tetrabenazine closely resemble those of reserpine, but it differs from the latter in having less peripheral activity and in being much shorter acting. In laboratory animals, tetrabenazine interferes with vesicular storage of biogenic amines, including dopamine as well as serotonin and norepinephrine; this effect is mainly limited to the brain. Hydroxytetrabenazine is believed to be the…