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NIFEDIPINE PA 10 NIFEDIPINE PA 20 Schein Pharmaceutical Nifedipine Antihypertensive Action And Clinical Pharmacology: Nifedipine is a calcium ion influx inhibitor (calcium channel blocker or calcium ion antagonist). The antihypertensive action of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into vascular smooth muscles. The contractile processes of vascular smooth muscle are dependent upon the movement…

NILSTAT® Technilab Nystatin Antifungal Antibiotic Indications And Clinical Uses: Oral Drops: Monilial infections of the mouth (thrush) and intestinal moniliasis in infants and children. Oral Tablets: Prevention and treatment of intestinal moniliasis. Prevention or treatment of lower intestinal and anal infections caused by Candida albicans (monilia). Powder: For the treatment of infections of the oral cavity by C. albicans (monilia). Cream and Ointment: Treatment of cutaneous or mucocutaneous mycotic infections…

NICORETTE® Hoechst Marion Roussel Nicotine Polacrilex Smoking Cessation Aid Action And Clinical Pharmacology: The active component of Nicorette is nicotine in the form of a natural extract from the tobacco plant. In small doses, nicotine stimulates autonomic ganglia. Larger doses of the drug result in a blockage of the ganglia. The effects on autonomic ganglia vary according to the degree of tolerance to nicotine. The major cardiovascular effects of nicotine…

NIDAGEL™ 3M Pharmaceuticals Metronidazole Antibacterial Action And Clinical Pharmacology: Metronidazole demonstrates antibacterial activity against bacteria classified as obligate anaerobes including Bacteroides and to a lesser extent against anaerobic gram-positive rods. The nitro group of the drug is thought to be reduced in the target cell leading to the production of cytotoxic metabolites. Bioavailability studies on the administration of a single 5 g dose of NidaGel into the vaginas of 12…

NICOTROL® Johnson & Johnson• Merck Nicotine Stop Smoking Aid Action And Clinical Pharmacology: Nicotrol is a multilayered, laminated, flexible thin film containing nicotine as the active ingredient. Nicotrol has been specifically designed to provide a 16-hour rate controlled delivery of nicotine following its application to intact skin. It is intended to be applied during the day and removed at night prior to sleeping, thus minimizing the potential for any sleep…

NIACIN NIACINAMIDE General Monograph, Nicotinic Acid, Vitamin B3 Nicotinamide Vitamin Action And Clinical Pharmacology: Niacin and niacinamide are water-soluble B complex vitamins. In vivo, niacin is converted to niacinamide, a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are coenzymes involved in glycogenolysis, tissue respiration and lipid metabolism. Niacin deficiency results in pellagra, a chronic wasting disease characterized by dermatitis, dementia and diarrhea. Niacin produces…

NICODERM® Hoechst Marion Roussel Nicotine Smoking Cessation Aid Action And Clinical Pharmacology: Nicoderm is a multilayered rectangular film containing nicotine as the active ingredient. It provides 24 hour rate-controlled delivery of nicotine following its application to intact skin. Nicoderm reduces the withdrawal symptoms associated with smoking cessation and thus increases the success rate of smoking cessation programs. Indications And Clinical Uses: As an aid to smoking cessation for partial relief…

NESACAINE®-CE Astra Chloroprocaine HCl Local Anesthetic Action And Clinical Pharmacology: Chloroprocaine stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthetic action. The onset of action is rapid (usually within 6 to 12 minutes). The duration of anesthesia depends on the procedure and the amount used, but could last up to 60 minutes. Chloroprocaine is rapidly hydrolyzed in plasma by pseudocholinesterase. This hydrolysis…

NEOSPORIN® Preparations Glaxo Wellcome Polymyxin B – Neomycin Compound Antibiotic Indications And Clinical Uses: Cream: Infection in dermatologic disorders particularly where the lesions are moist or weeping. Prophylactically, against bacterial contamination in burns, skin grafts, incisions and other clean lesions. For abrasions, minor cuts and wounds, the cream may prevent infection and permit normal healing. Irrigating Solution: To be diluted and used as a continuous irrigant or rinse for short-term…

NegGram® Sanofi Nalidixic Acid Urinary Antibacterial Action And Clinical Pharmacology: Nalidixic acid has bactericidal activity against gram-negative rods such as Escherichia, Klebsiella, Aerobacter and Proteus. It is relatively inactive against gram-positive bacteria. The mode of action is believed to be interference with the replication of genetic information by the blocking of the synthesis of bacterial DNA. Bacterial cross-resistance between nalidixic acid and other quinolone antimicrobials has been observed only with…