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OSTOFORTE® Frosst Vitamin D2 (Ergocalciferol) Vitamin Indications And Clinical Uses: Treatment of refractory rickets (vitamin D-resistant rickets), familial phosphatemia and hypoparathyroidism. Contra-Indications: Hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of vitamin D, hypervitaminosis D, decreased renal function. Precautions: Hypersensitivity to vitamin D may be one etiological factor in infants with idiopathic hypercalcemia. In these cases, vitamin D must be severely restricted. Pregnancy: Safety in excess of 400 IU…

OVOL® Preparations Carter Horner Simethicone Antiflatulent Indications And Clinical Uses: Specifically for symptomatic treatment of gastrointestinal discomfort due to entrapped gas. Relief of infant colic. Symptoms And Treatment Of Overdose: Symptoms and Treatment: Treatment symptomatic. Dosage And Administration: Drops: Infants, 0.25 to 0.50 mL with or after each meal. May be added to formula or given directly from dropper. Maximum: 6 mL/24 hours. Tablets: Adults: 40 mg (2 tablets, 4…

OXEZE® TURBUHALER® Astra Formoterol Fumarate Dihydrate Bronchodilator Action And Clinical Pharmacology: Pharmacodynamics: Formoterol produces bronchodilation by stimulation of the b2-adrenergic receptors in bronchial smooth muscle, thereby causing relaxation of smooth muscle fibres. Following inhalation of formoterol, a marked improvement in pulmonary function is observed within 1 to 3 minutes and lasts for a mean duration of 12 hours after a single dose. Pharmacokinetics: Absorption: Inhaled formoterol is rapidly absorbed. Peak…

OSMOVIST® Berlex Canada Iotrolan Dimeric Nonionic Radiographic Contrast Medium for Myelography Action And Clinical Pharmacology: Iotrolan is a dimeric, nonionic, hexaiodinated radiocontrast medium. The contrast-giving substance, iotrolan, is a dimer of triiodinated isophthalic acid derivatives, in which the firmly bound iodine absorbs the x-rays. Solutions of iotrolan are isotonic to plasma and cerebrospinal fluid at radiologically useful iodine levels. After intrathecal administration, iotrolan is absorbed from cerebrospinal fluid (CSF) into…

ORTHO® 1/35 ORTHO® 0.5/35 ORTHO® 10/11 ORTHO® 7/7/7 Janssen-Ortho Norethindrone – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: The primary mechanism of action of this product is an inhibition of ovulation. Additionally, other effects caused by the treatment (e.g., alteration of the endometrium and the thickening of the cervical mucus), appear to interfere with implantation and conception. Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or…

ORIFER® F Hoechst Marion Roussel Vitamins – Minerals Prenatal Supplement Indications And Clinical Uses: Dietary supplement in pregnancy; provides nutritional insurance against the common dietary deficiencies of pregnancy and postpartum. Precautions: Mild gastrointestinal upset may occur in iron-sensitive patients. The formulation is contraindicated in hemochromatosis, hemosiderosis and hemolytic anemia. Folic acid may obscure pernicious anemia in that the peripheral blood picture may return to normal while neurological manifestations remain progressive….

ORTHO-CEPT® Janssen-Ortho Desogestrel – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: The primary mechanism of action of Ortho-Cept tablets is an inhibition of ovulation. Additionally, other effects caused by the treatment (e.g., alteration of the endometrium and the thickening of the cervical mucus), appear to interfere with implantation and conception. tag_IndicationsIndications Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or thromboembolic disorders. History of/or actual cerebrovascular…

ORTHO® DIENESTROL Janssen-Ortho Dienestrol Vaginitis Therapy Action And Clinical Pharmacology: Dienestrol is a synthetic, nonsteroidal estrogen. The degree of systemic absorption and the mode of action are undetermined. However, one should be aware of the potential for systemic estrogen activity and related risks. Indications And Clinical Uses: The treatment of senile or atrophic vaginitis or other vaginal disturbances associated with hypoestrogenic conditions. Ortho Dienestrol cream is an estrogen product for…

ORAFEN® Technilab Ketoprofen Nonsteroidal Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Pharmacological studies in animals have demonstrated that ketoprofen is an NSAID that possesses anti-inflammatory, analgesic and antipyretic properties. The anti-inflammatory action is not mediated through the pituitary adrenal axis. Ketoprofen, like other nonsteroidal anti-inflammatory analgesics is an inhibitor of prostaglandin synthesis. In vivo studies have demonstrated that ketoprofen is 8 times as potent as indomethacin in inhibiting the synthesis…

OPTIRAY® Mallinckrodt Ioversol Radiopaque Medium Action And Clinical Pharmacology: General: The pharmacokinetics of ioversol in normal subjects conform to an open 2 compartment model with first order elimination (a rapid alpha phase 6.8 minutes, for drug distribution and a slower beta phase 92 minutes, for drug elimination). Based on the blood clearance curves for 12 healthy volunteers (6 receiving 50 mL and 6 receiving 150 mL of Optiray 320), the…