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PROGLYCEM® Schering Diazoxide Hyperglycemic Agent Action And Clinical Pharmacology: Diazoxide, a benzothiadiazine derivative, when administered orally produces a prompt dose-related increase in blood glucose level, due primarily to an inhibition of insulin release from the pancreas and also to an extrapancreatic effect. The hyperglycemic effect begins within an hour and generally lasts no more than 8 hours in the presence of normal renal function. Diazoxide decreases the excretion of sodium…

PROCTOFOAM™-HC R & C Hydrocortisone Acetate – Pramoxine HCl Anorectal Therapy Action And Clinical Pharmacology: Proctofoam-HC combines the anti-inflammatory action of hydrocortisone with the surface anesthetic effect of pramoxine HCl. tag_IndicationsIndications Indications And Clinical Uses: The temporary relief of anorectal inflammation, pruritus, pain and swelling associated with hemorrhoids, proctitis, cryptitis, fissures, postoperative pain and pruritus ani. Contra-Indications: The presence of active infection, abscess, extensive fistulas or sinus tracts, tuberculosis, varicella,…

PROCTOSEDYL® Hoechst Marion Roussel Hydrocortisone – Framycetin Sulfate – Cinchocaine HCl – Esculin Anorectal Therapy Indications And Clinical Uses: The reduction of swelling, pain and inflammation of hemorrhoids and other rectal lesions. The management of acute and chronic nonspecific proctitis, acute internal hemorrhoids, cryptitis, fissures and incomplete fistulas, internal and external pruritus ani. May be used in pre- and postoperative hemorrhoidectomy and repair of fissures. Contra-Indications: Hydrocortisone must not be…

PROCYTOX® Carter Horner Cyclophosphamide Antineoplastic Action And Clinical Pharmacology: Although it is classified generally as an alkylating agent, cyclophosphamide itself is not an alkylating agent. It appears to be inactive in vitro when tested on cultures of human leukocytes or carcinomatous cells of human origin. It appears active metabolites of the drug exhibit the alkylating action. carc Cyclophosphamide’s metabolism is initiated by the mixed function oxidase enzymes of the liver…

OXSORALEN™ ICN Methoxsalen Melanin Repigmentation – Photochemotherapy of Atopic Dermatitis and Psoriasis Indications And Clinical Uses: Repigmentation of vitiliginous lesions, to protect against solar sensitivity. Oral route is preferred if extensive repigmentation is desired, since topical application can only be applied to a small area at a time. For treatment of psoriasis and atopic dermatitis in combination with high intensity UVA light. Contra-Indications: Hepatic insufficiency. Diseases associated with photosensitivity, such…

OXYCONTIN® Purdue Frederick Oxycodone HCl Opioid Analgesic Action And Clinical Pharmacology: Oxycodone is a semisynthetic opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, oxycodone produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of…

OXYTOCIN INJECTION, USP Abbott Oxytocic Action And Clinical Pharmacology: Oxytocin synthetic, acts on the smooth muscle of the uterus to stimulate contractions; response depends on the uterine threshold of excitability. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions and raises the…

PROCAN™ SR Parke-Davis Procainamide HCl Antiarrhythmic Agent Action And Clinical Pharmacology: Procainamide depresses the excitability of cardiac muscle to electrical stimulation, and slows conduction in the atrium, the bundle of His, and the ventricle. The refractory period of the atrium is considerably more prolonged than that of the ventricle. With therapeutic plasma levels of the drug, contractility of the heart is usually not affected nor is cardiac output decreased to…

OXIZOLE® Stiefel Oxiconazole Nitrate Topical Antifungal Action And Clinical Pharmacology: Oxiconazole nitrate is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini,…

OTRIVIN® Novartis Consumer Health Xylometazoline HCl Nasal Decongestant Indications And Clinical Uses: Nasal congestion in colds, rhinitis, sinusitis; also for headache, tubal block and serous otitis media associated with nasal congestion. Xylometazoline facilitates rhinoscopy and is a useful pre- and postoperative adjunct. Contra-Indications: Narrow-angle glaucoma. Concurrent therapy with MAO inhibitors. Hypersensitivity to any component. Sensitivity to even small doses of adrenergic substances as manifested by sleeplessness, dizziness, lightheadedness, weakness, tremulousness,…