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MYOTONACHOL® Glenwood Bethanechol Chloride Parasympathomimetic Agent Action And Clinical Pharmacology: Bethanechol acts principally by producing the effects of stimulation of the parasympathetic nervous system. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores rhythmic peristalsis. Stimulation of the parasympathetic nervous system releases acetylcholine at the nerve endings….

M-ESLON® Rh´ne-Poulenc Rorer Morphine Sulfat Opioid Analgesic Action And Clinical Pharmacology: Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of the…

MYCOBUTIN® Pharmacia & Upjohn Rifabutin Antibacterial Agent Action And Clinical Pharmacology: Rifabutin is a derivative of rifamycin S, belonging to the class of ansamycins. The rifamycins owe their antimycobacterial efficacy to their ability to penetrate the cell wall and to their ability to complex with and to inhibit DNA-dependent RNA polymerase. Rifabutin has been found to interact with and to penetrate the outer layers of the mycobacterial envelope. Rifabutin inhibits…

MYCIGUENT® Pharmacia & Upjohn Neomycin Sulfate Topical Antibiotic Indications And Clinical Uses: The prevention and treatment of infection in minor skin breaks caused by cuts, scratches, burns and other injuries. Contra-Indications: Neomycin sensitivity. Precautions: Articles in current medical literature indicate an increase in the incidence of patients sensitive to neomycin. The possibility of such a reaction should be borne in mind. Discontinue use if sensitization occurs. As with any antibiotic…

MYCOSTATIN® Preparations Squibb Nystatin Antifungal Antibiotic Indications And Clinical Uses: Oral: Prevention and treatment of fun of the oral cavity and esophagus, for intestinal candidiasis and for protection against candidal overgrowth during antimicrobial or corticosteroid therapy. Topical: Treatment of cutaneous or mucocutaneous mycotic infections caused by Candida (Monilia) species. Vaginal: Local treatment of vaginal mycotic infections caused by C. albicans (Monilia) and other Candida species and treatment of pregnant patients…

MYLANTA™ Preparations Warner-Lambert Consumer Healthcare Aluminum Hydroxide – Magnesium Hydroxide Compound Antacid – Antiflatulent Indications And Clinical Uses: The treatment and relief of symptoms of peptic ulcer, gastritis, hiatus hernia, hyperacidity, and the management of gastrointestinal disorders accompanied by excessive gas or flatus. Contra-Indications: Alkalosis, hypermagnesemia, where distention may be due to partial or complete intestinal obstruction. Not recommended for severely debilitated patients or those with impaired renal function. Precautions:…

MYOCHRYSINE® Rh´ne-Poulenc Rorer Sodium Aurothiomalate Antirheumatic Agent Action And Clinical Pharmacology: Sodium aurothiomalate exhibits anti-inflammatory, antiarthritic and immunomodulating effects. The predominant clinical effect of sodium aurothiomalate appears to be suppression of the synovitis in the active stage of the rheumatoid disease. The precise mechanism of action is unknown but it has been suggested that the drug may act by inhibiting cell-mediated and humoral immune mechanisms. Additional modes of action include…

MYLERAN® Glaxo Wellcome Busulfan Antileukemic Action And Clinical Pharmacology: Busulfan is a bifunctional alkylating agent. Binding to DNA is believed to play a role in its mode of action, and di-guanyl derivatives have been isolated, but interstrand crosslinking has not been conclusively demonstrated. The basis for the uniquely selective effect of busulfan on granulocytopoiesis is not fully understood. Pharmacokinetics: Early pharmacokinetic studies were carried out with radioactively labelled busulfan. More…

LUTREPULSE™ Ferring Gonadorelin Acetate Ovulatory Agent Action And Clinical Pharmacology: Gonadorelin is a synthetic decapeptide that has the same amino acid sequence as endogenous gonadotropin-releasing hormone (GnRH) synthesized in the human hypothalamus and in various neurons terminating in the hypothalamus. Its pharmacological and toxicological profile is therefore identical to that of endogenous GnRH. Under physiologic conditions, GnRH is released by the hypothalamus in a pulsatile fashion. The primary effect of…

LUVOX® Solvay Pharma Fluvoxamine Maleate Antidepressant – Antiobsessional Agent Action And Clinical Pharmacology: The antidepressant and antiobsessional actions of fluvoxamine are believed to be related to its selective inhibition of presynaptic serotonin re-uptake in brain neurones. There is minimum interference with noradrenergic processes, and, in common with several other specific inhibitors of serotonin uptake, fluvoxamine has very little in vitro affinity for a1, a2, b1, dopamine2, histamine1, serotonin1, serotonin2 or…