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ADEKs® Pediatric Drops ADEKs® Tablets Axcan Pharma Multiple Vitamins – Zinc Sulfate Multiple Vitamins – Zinc Oxide Multiple Vitamin – Mineral Supplement Action And Clinical Pharmacology: Deficiencies of one or more of the fat-soluble vitamins may occur in the presence of steatorrhea or other malabsorption, hepatic dysfunction, protein malnutrition, zinc deficiency, and very low fat diets. As with all vitamins, adequate levels are essential to good health and proper growth….

ADENOCARD® Fujisawa Adenosine Antiarrhythmic Action And Clinical Pharmacology: Adenosine is an endogenous nucleoside occurring in all cells of the body. When injected i.v. adenosine slows atrioventricular (AV) nodal conduction, can interrupt the reentry pathways through the AV node and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White syndrome. Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline and potentiated…

ADRIAMYCIN® Pharmacia & Upjohn Doxorubicin HCl Antineoplastic Agent Action And Clinical Pharmacology: Though not completely elucidated, the mechanism of action of doxorubicin is related to its ability to bind to DNA and inhibit nucleic acid synthesis. Cell culture studies have demonstrated rapid cell penetration and perinucleolar chromatin binding, rapid inhibition of mitotic activity and nucleic acid synthesis, mutagenesis and chromosomal aberrations. Animal studies have shown activity in a wide spectrum…

ADRUCIL® Pharmacia & Upjohn Fluorouracil Antineoplastic Action And Clinical Pharmacology: The mechanism of action of fluorouracil is mainly related to competitive inhibition of thymidylate synthetase, the enzyme catalyzing the methylation of deoxyuridylic acid to thymidylic acid. The consequent thymidine deficiency results in inhibition of deoxyribonucleic acid (DNA) synthesis, thus inducing cell death. Also, moderate inhibition of ribonucleic acid (RNA) and incorporation of fluorouracil into RNA have been observed. The predominant…

ADALAT® Bayer Nifedipine Antianginal Action And Clinical Pharmacology: Nifedipine is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist). The antianginal effect of this group of drugs is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium ions into cardiac muscle and vascular smooth muscle. The contractile processes of these tissues are dependent upon the movement of extracellular calcium into…

ADALAT® PA 10 ADALAT® PA 20 Bayer Nifedipine Antihypertensive Action And Clinical Pharmacology: Nifedipine is a calcium ion influx inhibitor (calcium channel blocker or calcium ion antagonist). The antihypertensive action of this group of drugs is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium ions into vascular smooth muscles. The contractile processes of vascular smooth muscle are dependent upon the movement of…

ADALAT® XL® Bayer Nifedipine Antianginal – Antihypertensive System Components and Performance: Adalat XL extended release tablets, while similar in appearance to a conventional tablet, nonetheless consist of a semipermeable membrane surrounding an osmotically active drug core. The core itself is divided into 2 layers: an “active” layer containing the drug, and a “push” layer containing pharmacologically inert, but osmotically active components. As water from the gastrointestinal tract enters the tablet,…

ADEKs® Pediatric Drops ADEKs® Tablets Axcan Pharma Multiple Vitamins – Zinc Sulfate Multiple Vitamins – Zinc Oxide Multiple Vitamin – Mineral Supplement Action And Clinical Pharmacology: Deficiencies of one or more of the fat-soluble vitamins may occur in the presence of steatorrhea or other malabsorption, hepatic dysfunction, protein malnutrition, zinc deficiency, and very low fat diets. As with all vitamins, adequate levels are essential to good health and proper growth….

ACTIFED® Warner-Lambert Consumer Healthcare Triprolidine HCl – Pseudoephedrine HCl Antihistaminic – Decongestant Indications And Clinical Uses: The prophylaxis and treatment of symptoms associated with the common cold, acute and subacute sinusitis, acute eustachian salpingitis, serous otitis media with eustachian tube congestion, aerotitis media and croup; in allergic conditions which respond to antihistamines, including hay fever, pollenosis, allergic and vasomotor rhinitis. Contra-Indications: Hypersensitivity to triprolidine or pseudoephedrine. Should not be administered…

ACTIFED™ PLUS EXTRA STRENGTH Warner-Lambert Consumer Healthcare Acetaminophen – Pseudoephedrine HCl – Triprolidine HCl Analgesic – Antipyretic – Antihistamine – Decongestant Indications And Clinical Uses: The prophylaxis and treatment of symptoms associated with the common cold, acute and subacute sinusitis; in allergic conditions which respond to antihistamines, including hay fever, pollenosis, allergic and vasomotor rhinitis. Relieves nasal congestion, runny nose, sneezing, sinus pain, headache and fever. Contra-Indications: Hypersensitivity to triprolidine,…