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MEGRAL® Glaxo Wellcome Ergotamine Tartrate – Cyclizine HCl – Caffeine Hydrate Migraine Therapy Indications And Clinical Uses: The treatment of vascular headache, migraine and related conditions where distention of cranial vessels appears to be the cause. Contra-Indications: Sepsis, occlusive vascular disease (thromboangiitis obliterans, luetic arteritis, severe arteriosclerosis, coronary artery disease, thrombophlebitis, Raynaud’s disease), thyrotoxicosis, anemia, renal or hepatic disease, hypertension, angina pectoris, peptic ulcer, infectious states, malnutrition, severe pruritus, pregnancy,…

Measles Virus Vaccine, Live Attenuated (Dried) Connaught Vaccine Action And Clinical Pharmacology: Measles Virus Vaccine, Live, Attenuated (Dried) is prepared in avian leucosis-free chick embryo fibroblast cultures from the Edmondston Strain of attenuated measles virus, obtained from Dr. J.F. Enders and given an additional 69 passages in chick embryo cell cultures. The diluent for reconstitution for the 1 dose vial is Water for Injection (WFI). The diluent for reconstitution for…

MATERNA® Wyeth-Ayerst Multivitamins – Minerals Prenatal/Postpartum Supplement Indications And Clinical Uses: A multivitamin-mineral product for use as a dietary supplement during pregnancy, lactation and postpartum. Contra-Indications: Iron therapy is contraindicated in the presence of hemochromatosis, hemosiderosis, hemolytic anemia. Precautions: Folic acid may obscure pernicious anemia in that the peripheral blood picture may revert to normal while neurological manifestations remain progressive. Oral iron preparations may aggravate existing peptic ulcer, regional enteritis…

MAXIPIME™ Bristol-Myers Squibb Cefepime HCl Antibiotic Action And Clinical Pharmacology: Cefepime is a semi-synthetic broad spectrum cephalosporin antibiotic intended for i.m. or i.v. administration. Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. It has a broad spectrum of activity against a wide range of gram-positive and gram-negative bacteria. The average elimination half-life of cefepime is approximately 2 hours, and does not vary with respect…

MARCAINE® Sanofi Bupivacaine HCl Local Anesthetic Action And Clinical Pharmacology: Bupivacaine stabilizes the neuronal membrane and prevents both the generation and the conduction of nerve impulses, thereby exerting local anesthetic action. The onset of action is rapid, and anesthesia is long lasting. The advantage of bupivacaine over other local anesthetics is in the prolonged duration of effective anesthesia. It is to be noted however, that the duration of action of…

MAGNESIUM-ROUGIER Rougier Magnesium Glucoheptonate Magnesium Supplement Indications And Clinical Uses: In hypomagnesemic states: malnutrition, excessive gastrointestinal losses due to severe diarrhea or prolonged vomiting, malabsorption syndrome, liver cirrhosis, diabetic acidosis, chronic alcoholism, electrolyte abnormalities following the use of potent diuretics. Contra-Indications: Renal insufficiency. Precautions: Magnesium forms insoluble chelates with tetracyclines, thus inhibiting antibiotic absorption. Therefore, concomitant administration of magnesium and tetracyclines should be avoided. Administer magnesium cautiously in conjunction with…

M-M-R® II MSD Measles, Mumps and Rubella Virus Vaccine, Live, Attenuated, MSD Std Action And Clinical Pharmacology: M-M-R II is for immunization against measles (rubeola), mumps, and rubella (German measles). One injection of M-M-R II consists of Attenuvax (Measles Virus Vaccine, Live, Attenuated, MSD Std), Mumpsvax (Mumps Virus Vaccine, Live, Attenuated, MSD Std) and Meruvax II (Rubella Virus Vaccine, Live, Attenuated, MSD Std). Clinical studies of 279 triple seronegative children,…

M.V.I.-12 (Multivitamin Infusion) Rhône-Poulenc Rorer Multivitamins Vitamin Supplement Indications And Clinical Uses: This formulation is indicated as daily multivitamin maintenance dosage for adults and children aged 11 and above receiving parenteral nutrition. It is also indicated in other situations where administration by the i.v. route is required. Such situations include surgery, (including pre- and post-operative parenteral nutrition), extensive burns, fractures and other trauma, severe infectious diseases and comatose states, which…

MYLERAN® Glaxo Wellcome Busulfan Antileukemic Action And Clinical Pharmacology: Busulfan is a bifunctional alkylating agent. Binding to DNA is believed to play a role in its mode of action, and di-guanyl derivatives have been isolated, but interstrand crosslinking has not been conclusively demonstrated. The basis for the uniquely selective effect of busulfan on granulocytopoiesis is not fully understood. Pharmacokinetics: Early pharmacokinetic studies were carried out with radioactively labelled busulfan. More…

LEUSTATIN® Janssen-Ortho Cladribine Antineoplastic – Chemotherapeutic Agent Warning: Cladribine should be administered under the supervision of a qualified physician experienced in the use of antineoplastic therapy. Suppression of bone marrow function should be anticipated. This is usually reversible and appears to be dose-dependent. Significant and prolonged lymphopenia has been noted. Serious neurological toxicity (including irreversible paraparesis and quadriparesis) has been reported in patients who received cladribine injection by continuous infusion…