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PENICILLIN G PENICILLIN V General Monograph, Benzylpenicillin Phenoxymethylpenicillin Antibiotic Action And Clinical Pharmacology: Penicillins G and V, known as the natural penicillins, are bactericidal against susceptible organisms. Penicillins interfere with the synthesis of cell wall mucopeptides, resulting in the formation of defective cell walls that will lyse and eventually result in death of the organism. The spectra of activity of penicillins G and V are similar. Penicillin G is more…

PEDIASURE™ Abbott Therapeutic Nutrient Description: PediaSure liquid nutrition for children is an isotonic enteral nutritional product designed to provide complete balanced nutrition for children 1 to 10 years of age. Fed either by tube or orally, PediaSure can be used as total enteral nutrition support or as a supplement. Indications And Clinical Uses: Enteral nutritional support by tube or by mouth for children 1 to 10 years of age. Support…

PANCREASE® PANCREASE® MT Janssen-Ortho Pancrelipase Digestant Action And Clinical Pharmacology: The enteric-coated microtablets resist gastric inactivation and deliver predictable, high levels of biologically active pancreatic enzymes (lipase, amylase, and protease) into the duodenum. The enzymes catalyze the hydrolysis of fats into glycerol and fatty acids, proteins into proteoses and derived substances, and starch into dextrins and sugars. Pharmacokinetics: Absorption: The intestinal bioavailability of Pancrease MT 16 capsules was determined, in…

PANECTYL® Rhône-Poulenc Rorer Trimeprazine Tartrate Antipruritic – Antihistamine Action And Clinical Pharmacology: Trimeprazine is a propylamino phenothiazine derivative with reduced central activity and enhanced antihistaminic and antipruritic effects. It is a potent histamine antagonist. Trimeprazine possesses sedative properties, and is active in suppressing apomorphine induced vomiting in the dog. No evidence of teratogenic effect has been demonstrated in animal studies. Indications And Clinical Uses: Pruritus regardless of site or etiology….

PACIS™ Faulding Bacillus Calmette-Guerin (BCG), substrain Montreal Antineoplastic Action And Clinical Pharmacology: PACIS (Bacillus Calmette-Guerin (BCG), substrain Montreal) promotes a local inflammatory reaction with histiocytic and leukocytic infiltration in the urinary bladder. The local inflammatory effects are associated with an apparent elimination or reduction of superficial cancerous lesions of the urinary bladder. The exact mechanism by which this is accomplished is unknown. Indications And Clinical Uses: For intravesical use in…

PYRIBENZAMINE® Novartis Consumer Health Tripelennamine HCl Antihistamine Indications And Clinical Uses: Seasonal or nonseasonal allergic reactions. Precautions: Occupational Hazards: Patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been determined. Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics, sedatives, psychotherapeutic agents or…

NUPERCAINAL® Cream NUPERCAINAL® Ointment Novartis Consumer Health Dibucaine – Domiphen Bromide Topical Anesthetic Indications And Clinical Uses: For the relief of pain and itching in hemorrhoids, anal fissure, abrasions, minor burns, sunburn, chapping, herpes simplex, herpes zoster, insect bites, pruritus. The cream is also indicated for local antisepsis. Precautions: Not more than 2 tubes of the cream, or 1 tube of the ointment, should be applied within 24 hours to…

NIX® Dermal Cream Glaxo Wellcome Permethrin Topical Scabicide Action And Clinical Pharmacology: Permethrin is a synthetic pyrethroid, which is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance. Lag…

NIX® Creme Rinse Warner-Lambert Consumer Healthcare Permethrin Topical Pediculicide – Ovicide Action And Clinical Pharmacology: Permethrin is a synthetic pyrethroid, active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance….

NIFEDIPINE PA 10 NIFEDIPINE PA 20 Schein Pharmaceutical Nifedipine Antihypertensive Action And Clinical Pharmacology: Nifedipine is a calcium ion influx inhibitor (calcium channel blocker or calcium ion antagonist). The antihypertensive action of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into vascular smooth muscles. The contractile processes of vascular smooth muscle are dependent upon the movement…